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101.
J S Gelister J R Jass M Mahmoud P J Gaffney P B Boulos 《The British journal of surgery》1987,74(6):460-463
The biofunctional activity of the plasminogen activators urokinase and tissue plasminogen activator has been measured in extracts from 50 colorectal carcinomas and 21 adenomas using a bioimmunoassay. Compared with control mucosa urokinase activity was significantly elevated in adenomas (P less than 0.001) and carcinomas, levels being significantly higher in carcinomas (P less than 0.05). In contrast tissue plasminogen activator activity was reduced in adenomas (P less than 0.01) and carcinomas, levels being significantly lower in carcinomas (P less than 0.01). Although enzyme activity did not relate to Dukes' stage or histological grade urokinase activity was higher in carcinomas with venous invasion (n = 17, P less than 0.05), in those with moderate or extensive local spread (n = 27, P less than 0.05) and in cases where a palliative resection only was feasible because of advanced disease (n = 8, P less than 0.05). Urokinase has been implicated in tissue degradation as well as fibrinolysis and may play a role in tumour invasion and metastasis in human colorectal neoplasia. 相似文献
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Learn how a manager and her team used nine management principles to create a proactive nursing team while designing and opening a new inpatient unit. 相似文献
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Jones DJ Foster SE Olson AL Forehand RL Gaffney CA Zens MS Bau JJ 《Behavior modification》2007,31(5):638-659
This study examined the association between ecological context (extrafamilial, familial, child factors) at baseline and longitudinal retention of families in the 36-month assessment of an adolescent alcohol and tobacco use prevention program that was conducted within a pediatric primary care setting. A total of 1,780 families were enrolled at baseline when the youth were in the fifth and sixth grades, and 1,220 of these families participated in the 36-month assessment. Findings indicated that familial and child, but not extrafamilial, factors were associated with the participation of families in the 36-month assessment. Clinical implications and future research directions are discussed. 相似文献
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Paola G. Bronson Leanne K. Komorowski Patricia P. Ramsay Suzanne L. May Janelle Noble Julie A. Lane Glenys Thomson Frans H. Claas Michael F. Seldin Jennifer A. Kelly John B. Harley Kathy L. Moser Patrick M. Gaffney Timothy Behrens Lindsey A. Criswell Lisa F. Barcellos 《Arthritis \u0026amp; Rheumatology》2010,62(6):1712-1717