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991.
Salty or Sweet? Nutritional Quality,Consumption, and Cost of Snacks Served in Afterschool Programs 下载免费PDF全文
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Thiago Vinicius Ávila Amanda Leite Bastos Pereira Adriana De Oliveira Christoff Bruna Da Silva Soley José Ederaldo Queiroz Telles Gabrielle Jacklin Eler Adelar Bracht Aleksander Roberto Zampronio Alexandra Acco 《Fundamental & clinical pharmacology》2010,24(6):759-769
The aim of this study was to evaluate the actions of the non‐steroidal anti‐inflammatory drug flunixin‐meglumin (FM) on the changes caused by lipopolysaccharide (LPS)‐induced sepsis in the rat liver. Eight groups of five adult male Wistar rats were analysed: (1) saline injected (controls), (2) FM treated with 1.1 mg/kg, (3) FM treated with 2.2 mg/kg, (4) LPS‐injected (10 mg/kg), (5) LPS‐injected with 1.1 mg/kg FM pretreatment, (6) LPS‐injected with 2.2 mg/kg FM pretreatment, (7) LPS‐injected with 1.1 mg/kg FM post‐treatment and (8) LPS‐injected with 2.2 mg/kg FM post‐treatment. All drugs were intraperitoneally injected. The following parameters were evaluated: plasma levels of hepatic enzymes and urea, hepatic histological characteristics, antioxidant enzymes and several metabolic fluxes. The latter comprised gluconeogenesis, ureagenesis and oxygen consumption. Liver damage in LPS‐induced sepsis was characterized by histological changes, increased plasma levels of alanine aminotransferase and aspartate aminotransferase (P < 0.001) and diminished gluconeogenesis (P < 0.001) and ureagenesis (P < 0.01). LPS also induced oxidative stress as evidenced by increased catalase (P < 0.05) and superoxide dismutase activities and enhanced lipid peroxidation (P < 0.001). Pretreatment of the animals with FM minimized the histological changes and normalized, in part, all enzymatic activities. Pretreatment of the animals with FM also normalized gluconeogenesis and partly restored ureagenesis (P < 0.05). These and other results show that LPS‐induced sepsis may lead to severe liver damage, affecting both structure and function. Treatment with FM can be used to avoid this damage. The antioxidant properties of FM can be, partly at least, responsible for this protective action. 相似文献
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Marta O. Domingos Márcia R. FranzolinMarina Tavares dos Anjos Thais M.P. FranzolinRosely Cabette Barbosa Albes Gabrielle Ribeiro de AndradeRossivan J.L. Lopes Katia C. Barbaro 《Toxicon》2011,58(2):147-153
Invasion by bacteria can influence the course of healing of wounds acquired in aquatic environment. In this study, the bacteria present in Potamotrygon motoro stingray mucus and in the Alto Paraná river water were identified, and their ability to induce tissue injury and resist antibiotics was determined. Biochemical identification analysis showed that 97% of all bacterial isolates were Gram negative, Aeromonas spp., Enterobacter cloacae and Citrobacter freundii being the species most prevalent. Gelatinase and caseinase were produced by Aeromonas hydrophila, Aeromonas sobria and Pseudomonas aeruginosa strains. Erythrocyte hemolysis assay showed that A. sobria, A. hydrophila and to a lesser extent, other Gram-negative bacteria produced hemolysin. It was also observed that molecules released in culture by these bacteria were toxic to human epithelial cells. Antibiogram results showed that 68% of all bacterial isolates were resistant to at least one type of antibiotic, mainly B-lactams. Finally, it was demonstrated that although P. motoro venom was toxic to epithelial cells it did not influence bacterial proliferation. In summary, the results obtained in this work indicate that during the accident, the mucus of P. motoro and the environmental water may transfer into the wound pathogenic multi-resistant bacteria with the potential to cause severe secondary infections. 相似文献
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Tung-Sung Tseng Wei-Ting Lin Gabrielle V Gonzalez Yu-Hsiang Kao Lei-Shih Chen Hui-Yi Lin 《World journal of diabetes》2021,12(9):1530-1538
Type 2 diabetes mellitus (T2DM) is one of the fastest growing public health concerns around the world. Sugar-sweetened beverage (SSB) consumption has been proven to be associated with adverse health consequences in the diabetic population. Reducing SSB consumption, body weight control, healthy diets, and increased physical activity have been suggested as strategies to improve diabetes prevention and management. This literature review provides an overview of: (1) The association between SSB consumption and the risk of T2DM; (2) Types of SSB consumption and T2DM; (3) The effect of obesity and inflammation on the association between SSB consum ption and risk of T2DM; and (4) SSB consumption in T2DM patients. There is still work to be done to determine how SSB consumption is related to T2DM, but the current research on identifying the association between SSB consumption and T2DM is promising, with the most promising studies confirming the connection between SSBs, T2DM risk, and diabetes management. Future studies should explore more effective SSB related diabetes prevention and management interventions. 相似文献
995.
Antonio Luiz de Vasconcellos Macedo Vladimir Schraibman Samuel Okazaki Fernando Concilio Mauro Marina Gabrielle Epstein Suzan Menasce Goldman Suzana A. S. Lustosa Delcio Matos 《Journal of robotic surgery》2011,5(1):35-41
In the last few years, robotic surgery has started to take its place in pancreatic surgery. Robotic surgery provides advantages
such as enhanced visualisation and freedom of dissection within a confined space and also allows economical surgery. The aim
of this study was to evaluate the feasibility, safety and short-term outcome of the robotic approach using the da Vinci robotic
system in pancreatic/peripancreatic tumors other than pancreatic carcinomas. Fifteen patients with eight intraductal papillary
mucinous neoplasms, four pancreatic neuroendocrine and three periampulary tumors were included in this initial series. Seven
left pancreatectomies, five pancreatoduodenectomies and two total pancreatectomies were performed at Albert Einstein Hospital,
S?o Paulo, Brazil. The mean operating room time for all the procedures was 503 min (315–775 min). Blood transfusion was necessary
in one patient (3 units). The mean length of stay for all patients was 16 days (5–52 days). Large series of robotic pancreatic
surgery should be described and the decision as to its routine use will come from cumulative experience. This surgical system
allows difficult procedures to be performed more easily, effectively and precisely. 相似文献
996.
Bhakti Hansoti MBchB Kate Douglass MD MPH Janis Tupesis MD Michael S. Runyon MD Tracy Sanson MD Christine Babcock MD MSc Gabrielle Jacquet MD Erika D. Schroeder MD MPH David Hoffelder MD Ian B. K. Martin MD 《Academic emergency medicine》2013,20(4):413-420
The goal of a global health elective is for residents and medical students to have safe, structured, and highly educational experiences. In this article, the authors have laid out considerations for establishing a safe clinical site; ensuring a traveler's personal safety, health, and wellness; and mitigating risk during a global health rotation. Adequate oversight, appropriate mentorship, and a well‐defined safety and security plan are all critical elements to a successful and safe experience. 相似文献
997.
Mayte Suárez-Fariñas Minami Tokuyama Gabrielle Wei Ruiqi Huang Alexandra Livanos Divya Jha Anais Levescot Haritz Irizar Roman Kosoy Sascha Cording Wenhui Wang Bojan Losic Ryan C. Ungaro Antonio Di’Narzo Gustavo Martinez-Delgado Maria Suprun Michael J. Corley Aleksandar Stojmirovic Saurabh Mehandru 《Gastroenterology》2021,160(1):287-301.e20
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