全文获取类型
收费全文 | 2176篇 |
免费 | 164篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 98篇 |
妇产科学 | 54篇 |
基础医学 | 338篇 |
口腔科学 | 18篇 |
临床医学 | 255篇 |
内科学 | 351篇 |
皮肤病学 | 29篇 |
神经病学 | 383篇 |
特种医学 | 55篇 |
外科学 | 224篇 |
综合类 | 7篇 |
一般理论 | 2篇 |
预防医学 | 222篇 |
眼科学 | 24篇 |
药学 | 124篇 |
中国医学 | 1篇 |
肿瘤学 | 128篇 |
出版年
2024年 | 6篇 |
2023年 | 41篇 |
2022年 | 80篇 |
2021年 | 134篇 |
2020年 | 67篇 |
2019年 | 99篇 |
2018年 | 90篇 |
2017年 | 77篇 |
2016年 | 72篇 |
2015年 | 50篇 |
2014年 | 93篇 |
2013年 | 101篇 |
2012年 | 161篇 |
2011年 | 149篇 |
2010年 | 77篇 |
2009年 | 94篇 |
2008年 | 147篇 |
2007年 | 127篇 |
2006年 | 148篇 |
2005年 | 122篇 |
2004年 | 98篇 |
2003年 | 80篇 |
2002年 | 71篇 |
2001年 | 9篇 |
2000年 | 6篇 |
1999年 | 14篇 |
1998年 | 17篇 |
1997年 | 14篇 |
1996年 | 8篇 |
1995年 | 12篇 |
1994年 | 12篇 |
1993年 | 11篇 |
1992年 | 11篇 |
1991年 | 2篇 |
1990年 | 5篇 |
1989年 | 5篇 |
1988年 | 3篇 |
1987年 | 2篇 |
1986年 | 4篇 |
1982年 | 3篇 |
1981年 | 7篇 |
1975年 | 2篇 |
1974年 | 3篇 |
1972年 | 1篇 |
1971年 | 1篇 |
1969年 | 1篇 |
1968年 | 2篇 |
1967年 | 1篇 |
1964年 | 1篇 |
1962年 | 1篇 |
排序方式: 共有2345条查询结果,搜索用时 0 毫秒
91.
Gabrielle Todd Miranda Haberfield Patrick L. Faulkner Caroline Rae Michael Hayes Robert A. Wilcox Janet L. Taylor Simon C. Gandevia Jana Godau Daniela Berg Olivier Piguet Kay L. Double 《Journal of neural transmission (Vienna, Austria : 1996)》2014,121(11):1377-1386
Abnormal substantia nigra morphology in healthy individuals, viewed with transcranial ultrasound, is a significant risk factor for Parkinson’s disease. However, little is known about the functional consequences of this abnormality (termed ‘hyperechogenicity’) on movement. The aim of the current study was to investigate hand function in healthy older adults with (SN+) and without (SN?) substantia nigra hyperechogenicity during object manipulation. We hypothesised that SN+ subjects would exhibit increased grip force and a slower rate of force application compared to SN? subjects. Twenty-six healthy older adults (8 SN+ aged 58 ± 8 years, 18 SN? aged 57 ± 6 years) were asked to grip and lift a light-weight object with the dominant hand. Horizontal grip force, vertical lift force, acceleration, and first dorsal interosseus EMG were recorded during three trials. During the first trial, SN+ subjects exhibited a longer period between grip onset and lift onset (i.e. preload duration; 0.27 ± 0.25 s) than SN? subjects (0.13 ± 0.08 s; P = 0.046). They also exerted a greater downward force prior to lift off (?0.54 ± 0.42 N vs. ?0.21 ± 0.12 N; P = 0.005) and used a greater grip force to lift the object (19.5 ± 7.0 N vs. 14.0 ± 4.3 N; P = 0.022) than SN? subjects. No between group differences were observed in subsequent trials. SN+ subjects exhibit impaired planning for manipulation of new objects. SN+ individuals over-estimate the grip force required, despite a longer contact period prior to lifting the object. The pattern of impairment observed in SN+ subjects shares similarities with de novo Parkinson’s disease patients. 相似文献
92.
93.
94.
95.
美国国立神经疾病和卒中研究所-加拿大卒中网血管性认知障碍统一标准 总被引:20,自引:11,他引:9
Ron C.Petersen Sandra E.Black Charles DeCarli Jose G.Merino Raj N.Kalaria Harry V.Vinters Martin Dichgans John R.Marler 李焰生 俞羚 高枚春 张静芳 熊昕丽 邹静 林岩 潘元美 《国际脑血管病杂志》2007,15(1):4-24
背景和目的:1/3的个体会罹患卒中和(或)痴呆,而且,除卒中或痴呆外,2倍于此数的人会出现认知障碍。常用的卒中量表并不能评价认知功能,而痴呆的诊断标准则集中在认知障碍的晚期阶段,且在很大程度上偏向Alzheimer病(AD)的诊断。尚缺乏普遍公认的标准用于识别和描述存在认知障碍的个体,尤其是在早期阶段,而且特别是与血管因素有关的认知障碍或血管性认知障碍。方法:美国国立神经疾病和卒中研究所(MINDS)与加拿大卒中网(CSN)召集临床诊断、流行病学、神经心理学、脑影像学、神经病理学、试验模型、生物标记物、遗传学和临床试验方面的研究人员,为血管性认知障碍的描述和研究推荐一些最低限度的常用的临床和研究标准。结果:将这些讨论的结果发表于此。结论:一个统一标准的制定代表着使用、确认和改进过程中的第一步。使用相同的标准将有助于在认知障碍的早期阶段识别患者,使不同的研究具有可比性,并且通过整合知识来加速研究进展的步伐。 相似文献
96.
Omar Asdrúbal Vilca Mejia Bruno Mahler Mioto Gabrielle Barbosa Borgomoni Juliana Mendanha Camilo Danielle Misumi Watanabe Sirlei Pereira Nunes Vanessa Santos Sallai Maraina Pegorini Librio de Lima Jurema da Silva Herbas Palomo Helenice Moreira da Costa Elisandra Trevisan Arita Maria Ignêz Zanetti Feltrim Vera Coimbra Roger Daglius Dias Filomena Regina Barbosa Gomes Galas Jos Otvio Costa Auler Junior Fabio Biscegli Jatene 《Arquivos brasileiros de cardiologia》2022,118(1):110
97.
Arjun Muralidharan Susana G. Sotocinal Noosha Yousefpour Nur Akkurt Lucas V. Lima Shannon Tansley Marc Parisien Chengyang Wang Jean-Sebastien Austin Boram Ham Gabrielle M.G.S. Dutra Philippe Rousseau Sioui Maldonado-Bouchard Teleri Clark Sarah F. Rosen Mariam R. Majeed Olivia Silva Rachel Nejade Xinyu Li Stephania Donayre Pimentel Christopher S. Nielsen G. Gregory Neely Chantal Autexier Luda Diatchenko Alfredo Ribeiro-da-Silva Jeffrey S. Mogil 《The Journal of clinical investigation》2022,132(8)
Mice with experimental nerve damage can display long‑lasting neuropathic pain behavior. We show here that 4 months and later after nerve injury, male but not female mice displayed telomere length (TL) reduction and p53‑mediated cellular senescence in the spinal cord, resulting in maintenance of pain and associated with decreased lifespan. Nerve injury increased the number of p53‑positive spinal cord neurons, astrocytes, and microglia, but only in microglia was the increase male‑specific, matching a robust sex specificity of TL reduction in this cell type, which has been previously implicated in male‑specific pain processing. Pain hypersensitivity was reversed by repeated intrathecal administration of a p53‑specific senolytic peptide, only in male mice and only many months after injury. Analysis of UK Biobank data revealed sex-specific relevance of this pathway in humans, featuring male‑specific genetic association of the human p53 locus (TP53) with chronic pain and a male-specific effect of chronic pain on mortality. Our findings demonstrate the existence of a biological mechanism maintaining pain behavior, at least in males, occurring much later than the time span of virtually all extant preclinical studies. 相似文献
98.
Francois Rheault Kurt G. Schilling Alex ValcourtCaron Antoine Thberge Charles Poirier Gabrielle Grenier Guido I. Guberman John Begnoche Jon Haitz Legarreta Leon Y. Cai Maggie Roy Manon Edde Marco Perez Caceres Mario OcampoPineda Noor AlSharif Philippe Karan Pietro Bontempi Sami Obaid Sara Bosticardo Simona Schiavi Viljami Sairanen Alessandro Daducci Laurie E. Cutting Laurent Petit Maxime Descoteaux Bennett A. Landman 《Human brain mapping》2022,43(7):2134
The segmentation of brain structures is a key component of many neuroimaging studies. Consistent anatomical definitions are crucial to ensure consensus on the position and shape of brain structures, but segmentations are prone to variation in their interpretation and execution. White‐matter (WM) pathways are global structures of the brain defined by local landmarks, which leads to anatomical definitions being difficult to convey, learn, or teach. Moreover, the complex shape of WM pathways and their representation using tractography (streamlines) make the design and evaluation of dissection protocols difficult and time‐consuming. The first iteration of Tractostorm quantified the variability of a pyramidal tract dissection protocol and compared results between experts in neuroanatomy and nonexperts. Despite virtual dissection being used for decades, in‐depth investigations of how learning or practicing such protocols impact dissection results are nonexistent. To begin to fill the gap, we evaluate an online educational tractography course and investigate the impact learning and practicing a dissection protocol has on interrater (groupwise) reproducibility. To generate the required data to quantify reproducibility across raters and time, 20 independent raters performed dissections of three bundles of interest on five Human Connectome Project subjects, each with four timepoints. Our investigation shows that the dissection protocol in conjunction with an online course achieves a high level of reproducibility (between 0.85 and 0.90 for the voxel‐based Dice score) for the three bundles of interest and remains stable over time (repetition of the protocol). Suggesting that once raters are familiar with the software and tasks at hand, their interpretation and execution at the group level do not drastically vary. When compared to previous work that used a different method of communication for the protocol, our results show that incorporating a virtual educational session increased reproducibility. Insights from this work may be used to improve the future design of WM pathway dissection protocols and to further inform neuroanatomical definitions. 相似文献
99.
Perceptions of the Cause,Impact and Management of Persistent Fatigue in Patients with Rheumatoid Arthritis Following Tumour Necrosing Factor Inhibition Therapy 下载免费PDF全文
100.
Brittany OwusuAdjei Charles Ogagan Jordan Smith Gabrielle Luiselli Mark D. Johnson 《Clinical Case Reports》2022,10(1)
Bacterial translocation as a mechanism of distal catheter infection may play a larger role in ventriculoperitoneal shunt infections than previously recognized. 相似文献