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991.
992.
993.
Van Landeghem G; Haese P; Lamberts L; Barata J; DeBroe M 《Nephrology, dialysis, transplantation》1997,12(8):1692-1698
Background: The association between aluminium and
dialysis encephalopathy and deterioration of the neurological state during
desferrioxamine treatment of dialysis patients is well established. At
present little is known about the speciation and the mechanisms underlying
the element's neurotoxicity. Methods. Aluminium speciation was performed in
cerebrospinal fluid samples of acutely aluminium-intoxicated dialysis
patients using a recently developed high-performance liquid
chromatographic/electro-thermal atomic absorption spectrometric hybrid
method. Results: Baseline cerebrospinal fluid
aluminium levels of samples taken shortly after the intoxication were low
but elevated (5.0±2.0 &mgr;g/l, n=3) as compared to subjects
with normal renal function (<1 &mgr;g/l). In contrast to the
situation noted in serum and to the iron speciation in cerebrospinal fluid,
aluminium was not bound to transferrin but appeared as two distinct
compounds, the main fraction eluting at the elution volume of aluminium
citrate/silicate. The second compound was not identified. Forty-four hours
after desferrioxamine administration the cerebrospinal fluid aluminium
levels had increased up to a concentration of 10.3±2.5
&mgr;g/l (n=3). This was accompanied by a change in the speciation
profile with aluminium appearing at the elution volume of aluminoxamine.
Conclusion: Our findings may contribute to a better
understanding of the neurotoxic effects of aluminium and its
desferrioxamine chelate in dialysis patients. 相似文献
994.
To date, only 10 cases of distal penile gangrene in patients with chronic renal failure have been reported. This rare condition is believed to result from progressive vascular calcification due to secondary hyperparathyroidism in patients with chronic renal failure. We report an additional case of distal penile gangrene in a 41-year-old man who presented with chronic renal disease and pulmonary tuberculosis. Since some authors have emphasized that aggressive surgical treatment in such cases has a significant mortality rate, we took a more conservative approach to treatment. 相似文献
995.
996.
997.
998.
G. V. Petrova V. A. Adarichev A. A. Krivenko G. S. Dymshits A. L. Markel' G. S. Yakobson 《Bulletin of experimental biology and medicine》1997,124(2):773-775
Sensitivity of normotensive Wistar rats and NISAG rats (with hereditary arterial hypertension) to heat stress is compared
at the organism and cell levels. High temperature sensitivity of NISAG rats correlates with a low content of the main heat
shock protein HSP70. This relationship can serve as a biochemical marker of predisposition to arterial hypertension.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 171–173, August, 1997 相似文献
999.
1000.
C M Kyaw C R De Araujo M R Lima E G S Gondim M M Brígido L G Giugliano 《Infection, genetics and evolution》2003,3(2):111-117
Diffusely adhering Escherichia coli (E. coli) strains (DAEC) represent a potential cause of diarrhoea in infants, and the detection of type three secretion system (TTSS) genes in DAEC would substantiate their pathogenic nature. In this work, four isolates of DAEC, recovered from stools of diarrhoeic children, were analysed by PCR, in order to detect the presence of TTSS genes. Primers targeted to the escC, escJ, escN and escV, some of the most conserved TTSS genes in enteropathogenic and enterohaemorrhagic Escherichia coli (EPEC and EHEC), were used in order to verify the occurrence of homologous genes in our DAEC isolates. By this approach, we were able to characterise DNA fragments corresponding to putative escJ and escN genes in all DAEC isolates. Furthermore, DNA fragments homologous to the escC and escV genes were also amplified from all isolates. Besides the similarity found among the DAEC esc homologues with EPEC and EHEC esc genes, the nucleotide sequence analysis of the flanking regions of the amplified DNA fragments suggests that the putative DAEC esc genes are organised in the same manner as observed in EPEC and in EHEC strains. The results described here provide strong evidence for the presence of a TTSS in the DAEC strains analysed, implicating a pathogenic nature of these isolates. 相似文献