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441.
Kentaro Omori Junichiro James Kazama Jin Song Shin Goto Toshinori Takada Noriko Saito Minoru Sakatsume Ichiei Narita Fumitake Gejyo 《Amyloid》2002,9(3):175-182
Carpal-tunnel syndrome (CTS) in long-term hemodialysis patients is caused by the deposition of amyloid as well as by the local inflammatory process. The recruitment of monocytes/macrophages in the tenosynovium, promoted by chemokines such as monocyte chemoattractant protein-1 (MCP-1) and macrophage inflammatory protein-1alpha (MIP-1alpha), is thought to play an important role in CTS development. The genetic polymorphism of these chemokines has been identified and their clinical function has been partly revealed We attempted to analyze the relationship between these polymorphisms and their susceptibility to CTS. The subjects of this study were 366 patients who underwent hemodialysis. Ninety-five patients received surgery for CTS. No significant difference was observed in the genotype distributions of MCP-1 or MIP-1alpha between patients who received CTS surgery and those that did not. However, with the use of a logistic regression model, the MCP-1 GG genotype was identified as a risk factor for the development of CTS, in addition to the duration and the age of initiation of dialysis, as confirmed by a Cox proportional hazards model. In conclusion, homozygosity for G at -2518 in the MCP-1 gene might be a candidate for the genetic marker of CTS development in Japanese hemodialysis patients. 相似文献
442.
K Hara H Tanaka H Moriyama T Ohdaira T Takada E Suzuki M Arakawa G Fumitake 《Nihon Kokyūki Gakkai zasshi》2000,38(7):566-570
A 28 year-old man complaining of intermittent headaches for a month following an episode of general convulsions was admitted to the Department of Neurosurgery of our hospital. His brain CT scan showed a well-enhanced mass growing symmetrically along the anterior cerebral falx in a manner compatible with meningioma. Nothing abnormal was detected in chest radiography on admission. Histopathological examination of the mass after partial resection revealed multiple epithelioid cell granulomas with giant cells indicating sarcoidosis. After 4 weeks of treatment with oral prednisolone 30 mg/day, bronchoalveolar lavage was performed in our department. In the lavage fluid, both the total cell count and the percentage of lymphocytes were elevated. The lung specimens obtained by transbronchial biopsy also showed epithelioid cell granulomas. CNS sarcoidosis is reportedly usually observed in the vicinity of the hypothalamus with other organ involvement. In the present case, differential diagnosis of sarcoidosis from meningioma was difficult because the solitary lesion was growing along the anterior cerebral falx without radiographic evidence of bilateral hilar lymphadenopathy. 相似文献
443.
Kuroda T Ohbayashi H Murakami S Ito S Sakatsume M Ueno M Nishi S Nakano M Gejyo F 《Clinical rheumatology》2004,23(6):536-540
We report on a 65-year-old Japanese woman with Takayasu arteritis who developed severe proteinuria, hypertension, and renal dysfunction. Renal angiography demonstrated moderate irregular narrowing of both renal arteries. Renal biopsy showed glomerulonephropathy mimicking membranoproliferative glomerulonephritis (MPGN) with glomerular capillary wall thickening (double contour) accompanied by mesangial cell proliferation and moderate increase of mesangial matrix without deposits of C3. Electron microscopy showed no subendothelial deposit and no circumferential mesangial interposition (CMI), and these findings are different from MPGN. In this report we present a case of Takayasu arteritis associated with glomerulonephropathy mimicking MPGN. 相似文献
444.
Tomoko Suzuki Takashi Hasegawa Eiich Suzuki Kazuhisa Sasahara Tomie Kawada Toshiyuki Koya Kohei Akazawa Hiroshi Satoh Fumitake Gejyo 《Allergy and asthma proceedings》2003,24(5):347-351
Recent studies have shown that fluticasone propionate (FP) was more effective than beclomethasone dipropionate (BDP) inhalation even at a dose reduced by twofold or more in the treatment of bronchial asthma. Here, we further compared the effectiveness of FP and BDP, including rates of drug compliance. Forty-two symptomatic patients were treated by BDP (1000 +/- 345; mean +/- SD; microgram/day) for 8 weeks, followed by FP at one-half the respective dose, and peak expiratory flow and forced expiratory volume in 1 second were investigated. In addition, the patients were asked about drug compliance and factors related to compliance (expressed using a visual analogue scale). Significant increases of peak expiratory flow (from 316 +/- 96 L/minute to 345 +/- 86 L/minute) and forced expiratory volume in 1 second (from 1.7 +/- 0.5 L to 1.9 +/- 0.4 L) were found. Furthermore, significantly higher scores were obtained for compliance and various factors related to compliance. These data indicate that FP is more effective than a twofold higher dosage of BDP and that better compliance with the use of FP, probably because of improved various factors associated with FP compliance, contributes to FP efficacy. 相似文献
445.
Wada Y Murayama N Hirose S In H Kuroda T Ito S Nakano M Gejyo F 《Modern rheumatology / the Japan Rheumatism Association》2004,14(3):260-263
We report the case of a 49-year-old man who presented with pneumatosis cystoides intestinalis associated with polymyositis and interstitial pneumonia. Three months after the administration of prednisolone and cyclosporine, he noticed mild abdominal distension, and a radiographic examination showed intraperitoneal free gas and intramural gas, suggestive of pneumatosis cystoides intestinalis (PCI). Additional treatment with a combination of doxycycline and high-dose oxygen therapy was effective in relieving the clinical symptoms and reducing the intramural gas. 相似文献
446.
Motosugi U Ichikawa T Amemiya F Sou H Sano K Muhi A Enomoto N Araki T 《Journal of magnetic resonance imaging : JMRI》2012,35(3):607-610
Purpose:
To evaluate individual differences in liver stiffness measurement using both MR elastography (MRE) and ultrasound transient elastography (UTE) in patients with chronic liver disease.Materials and Methods:
This study included 80 patients with chronic liver disease who underwent both UTE and MRE. MRE and UTE were performed using a pneumatic driver (60 Hz) and an ultrasound probe with a vibrator (50 Hz), respectively. Liver stiffness data measured using the two techniques (μUTE and μMRE) were compared with respect to shear modulus. The patients were subdivided into four quartiles on the basis of average of the μUTE and μMRE values for each patient.Results:
The analysis of the 4 quartile groups revealed that μUTE was significantly higher than μMRE in the two most stiff liver groups: μUTE versus μMRE, 7.5 (1.2) versus 6.0 (0.72) kPa for the group with [μUTE + μMRE]/2 of 5.6–8.0 kPa; 15.1(4.2) versus 6.7 (1.4) kPa for the group with >8.0 kPa. However, in the least stiff liver group (i.e., the group with [μUTE + μMRE]/2 < 3.2 kPa), μUTE was significantly lower than μMRE.Conclusion:
The shear modulus measured by UTE and MRE are not equivalent, especially in patients with stiff livers. J. Magn. Reson. Imaging 2012;35:607‐610. © 2011 Wiley Periodicals, Inc. 相似文献447.
Saito F Tasaka S Inoue K Miyamoto K Nakano Y Ogawa Y Yamada W Shiraishi Y Hasegawa N Fujishima S Takano H Ishizaka A 《American journal of respiratory cell and molecular biology》2008,38(5):566-571
Interleukin-6 (IL-6) is known to be involved in the pathogenesis of various inflammatory diseases, but its role in bleomycin (BLM)-induced lung injury and subsequent fibrotic changes remains to be determined. We evaluated the role of IL-6 in the lung inflammatory changes induced by BLM using wild-type (WT) and IL-6-deficient (IL-6(-/-)) mice. The mice were treated intratracheally with 1 mg/kg BLM and killed 2, 7, or 21 days later. Lung Inflammation in the acute phase (Days 2 and 7) was assessed by differential cell counts in bronchoalveolar lavage (BAL) fluid and cytokine levels in the lung. Lung fibrotic changes were evaluated on Day 21 by histopathology and collagen assay. On Day 2, BLM administration induced significant increases in the numbers of total cells, macrophages, and neutrophils in BAL fluid, which were attenuated in IL-6(-/-) mice (P < 0.05). Lung pathology also showed inflammatory cell accumulation, which was attenuated in the IL-6(-/-) mice compared with WT mice. In WT mice, elevated levels of TGF-beta(1) and CCL3 were observed 2 and 7 days after BLM challenge, respectively. On Day 7, BLM-induced inflammatory cell accumulation did not differ between the genotypes. Lung pathology 21 days after BLM challenge revealed significant fibrotic changes with increased collagen content, which was attenuated in IL-6(-/-) mice. Although the TGF-beta(1) level in the lung did not differ between the genotypes on Day 21, CCL3 was significantly lower in IL-6(-/-) mice. These results indicate that IL-6 may play an important role in the pathogenesis of BLM-induced lung injury and subsequent fibrotic changes. 相似文献
448.
449.
Ayano Yoshido Gota Sudo Akira Takasawa Hironori Aoki Hiroshi Kitajima Eiichiro Yamamoto Takeshi Niinuma Taku Harada Toshiyuki Kubo Hajime Sasaki Kazuya Ishiguro Akira Yorozu Masahiro Kai Akio Katanuma Hiro-o Yamano Makoto Osanai Hiroshi Nakase Hiromu Suzuki 《Journal of gastroenterology and hepatology》2023,38(2):301-310