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141.
Shu Zhu Aimi Shirakawa Yanhong Shi Xiaoli Yu Takayuki Tamura Naotoshi Shibahara Kayo Yoshimatsu Katsuko Komatsu 《Journal of natural medicines》2018,72(3):757-767
The impact of key processing steps such as boiling, peeling, drying and storing on chemical compositions and morphologic features of the produced peony root was investigated in detail by applying 15 processing methods to fresh roots of Paeonia lactiflora and then monitoring contents of eight main components, as well as internal root color. The results showed that low temperature (4 °C) storage of fresh roots for approximately 1 month after harvest resulted in slightly increased and stable content of paeoniflorin, which might be due to suppression of enzymatic degradation. This storage also prevented roots from discoloring, facilitating production of favorable bright color roots. Boiling process triggered decomposition of polygalloylglucoses, thereby leading to a significant increase in contents of pentagalloylglucose and gallic acid. Peeling process resulted in a decrease of albiflorin and catechin contents. As a result, an optimized and practicable processing method ensuring high contents of the main active components in the produced root was developed. 相似文献
142.
Komatsu S 《Nihon rinsho. Japanese journal of clinical medicine》2007,65(4):670-674
A plain chest X-ray is not useful for the diagnosis of early stage of COPD, but severe COPD has some characteristic radiographic signs. Because of absence of vasculature, radiolucency of lung fields is recognized. Depression and flattening of the diaphragm, tear -drop heart and increase in the retrosternal airspace are detected as signs of lung hyperinflation. High-resolution CT(HRCT) scanning is more sensitive to diagnose of COPD. COPD can be detected as low attenuation area. CT is also useful in classifying patterns of emphysema(centriacinar, panacinar and distal acinar type). Although the assessment of COPD is still limited by MRI, progress of MRI techniques in pulmonary ventilation, such as hyperpolarized noble gas MRI and oxygen enhanced MRI, enabled evaluation of COPD. 相似文献
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Endo T Osada T Finger WJ Hoffmann M Kanehira M Komatsu M 《The journal of adhesive dentistry》2007,9(1):33-38
PURPOSE: To determine effects of light curing of self-etching adhesives under ambient air or nitrogen on inhibition depths, enamel and dentin bond strengths, and marginal adaptation in dentin cavities. MATERIALS AND METHODS: The adhesives investigated were: AQ Bond (AQB, Sun Medical; Kyoto, Japan), iBond (IBO, Heraeus Kulzer; Hanau, Germany), One-Up Bond F II (OUB, Tokuyama; Tokyo, Japan), and Prompt L-Pop (PLP, 3M/ESPE; Seefeld, Germany). Inhibition layer thickness (ILT) was microscopically measured on 3 disk-shaped specimens each. Shear bond strengths (SBS) on enamel and dentin (n = 8) were determined after 10 min and 24 h water storage of bonded composite specimens (Venus, Heraeus Kulzer). The marginal adaptation of bonded Venus restorations in cylindrical dentin cavities was microscopically evaluated after 10 min of specimen storage (n = 8) in water. The data were statistically analyzed using parametric and nonparametric ANOVA and post-hoc tests at p < 0.05. RESULTS: Adhesive curing under air revealed significant ILT (microm) differences: IBO (4) < AQB (8) < PLP (12) < OUB (23). Upon curing in nitrogen atmosphere, no inhibition occurred with AQB, IBO, and PLP, and < 3 microm for OUB. SBSs on enamel after 10 min or 24 h did not differ according to curing atmospheres (p > 0.05). On dentin, SBSs were higher after curing under N2 (p < 0.05). Irrespective of the curing atmosphere, marginal adaptation was good for AQB and IBO and poor for PLP; OUB revealed significantly smaller gaps under N2 than under air curing. CONCLUSION: Oxygen inhibition of the four self-etching adhesives investigated had no or only moderate effects on bonding efficacy to enamel and dentin. 相似文献
145.
Yamaguchi T Komatsu K Okada K Matsuki T Gotouda A 《Cranio : the journal of craniomandibular practice》2007,25(1):50-56
The purpose of this study was to clarify which direction of the condylar path is advantageous for releasing TMJ intermittent lock. The subjects were ten patients with temporomandibular disorders (TMD) and intermittent lock caused by anterior displacement of disks without obvious medial or lateral displacement. The patients could not open their mouths fully in habitual opening but could open fully in an intentional winding opening with reduction of the anteriorly displaced disks (winding opening). The two kinds of movement at the kinematic condylar point were measured in each subject and compared. The length of the condylar path in winding opening was significantly larger than that in habitual opening. The affected side condyle of winding opening traced medio-inferior paths in the early part of the condylar translation in comparison with habitual opening. From the viewpoint of the condylar path, the medio-inferior direction of condylar translation is thought to be advantageous for releasing intermittent lock. 相似文献
146.
Takako Saisho Hattori Nobukazu Komatsu Shigeki Shichijo Kyogo Itoh 《Biomedicine & Pharmacotherapy》2004,58(4):226-230
Protein-bound polysaccharide K (PSK), which is derived from mushrooms belonging to the Basidiomycetes genus, has been clinically used as a biological response modifier (BRM) for the treatment of epithelial cancer patients in Japan and other Asian countries. There are a large number of studies on the biological activities of PSK as regards the activation of immunocompetent cells and the potential cytotoxic effects on epithelial cancer cells. However, only a few studies have been conducted to see the direct cytotoxic effects of PSK on hematological malignant cells. In this study, we investigated whether or not PSK was able to induce cellular apoptosis in hematological malignant cells. PSK was found to inhibit cell growth, and induced subsequent cellular apoptosis in the Burkkit lymphoma cell line (Namalwa), out of 33 hematological malignant cell lines tested. This PSK-induced apoptosis was neutralized by the addition of galactose to the culture medium, whereas apoptosis was augmented by treatment with beta-galactosidase, indicating the inhibitory involvement of galactose in the mechanism of action. These results provide initial evidence of the direct cytotoxic activity of PSK in a hematological malignant cell line, thus encouraging further molecular-level study of PSK-mediated apoptosis in malignant hematological cells. 相似文献
147.
Kato Shunji Shiozaki Atsushi Kudou Michihiro Shimizu Hiroki Kosuga Toshiyuki Ohashi Takuma Arita Tomohiro Konishi Hirotaka Komatsu Shuhei Kubota Takeshi Fujiwara Hitoshi Okamoto Kazuma Kishimoto Mitsuo Konishi Eiichi Otsuji Eigo 《Annals of surgical oncology》2022,29(5):2944-2956
Annals of Surgical Oncology - Transient receptor potential vanilloid 2 (TRPV2) is a highly Ca2+-permeable ion channel that is involved in a number of cellular processes. It is expressed in various... 相似文献
148.
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150.
Satoshi Shimura Hideo Watari Masaru Komatsu Tomokazu Kuchibiro Saori Fukuda Hisaaki Nishio Machiko Kita Kaneyuki Kida Masanobu Oohama Hirofumi Toda Motoi Nishio Isao Nishi Keigo Kimura Kana Sawa Nozomi Fukuda Tomomi Kofuku Isako Nakai Makoto Niki Yasunao Wada 《Journal of infection and chemotherapy》2019,25(11):837-844
Obligate anaerobes exist as resident flora in various sites in humans, but they are also emphasized as endogenous causative microorganism of infections. We performed surveillance to understand the trend of drug susceptibility in obligate anaerobic bacteria in the Kinki area of Japan. In the experiment, we used 156 obligate anaerobe isolates collected from 13 institutions that participated in the Study of Bacterial Resistance Kinki Region of Japan. MALDI Biotyper was used to identify the collected strains, and among the 156 test strains, those that could be identified with an accuracy of Score Value 2.0 or more included 6 genera, 30 species, and 144 strains (Bacteroides spp. 77 strains, Parabacteroides sp. 2 strains, Prevotella spp. 29 strains, Fusobacterium spp. 14 strains, Porphyromonas spp. 2 strains, and Clostridioides difficile 20 strains), and they were assigned as subject strains for drug susceptibility testing. The drug susceptibility test was carried out by broth microdilution method using Kyokuto Opt Panel MP ANA (Kyokuto Pharmaceutical Industrial Co., Ltd., Tokyo, Japan) and judged according to CLSI criteria. As a result, Bacteroides and Parabacteroides species showed good sensitivities to tazobactam-piperacillin, imipenem, metronidazole and chloramphenicol, and low sensitivities to ampicillin, cefoperazone and vancomycin. Prevotella species showed good sensitivities to sulbactam-ampicillin, tazobactam-piperacillin, cefmetazole, imipenem, doripenem and metronidazole. Susceptibility rates to other drugs were slightly different depending on the bacterial species. Both Fusobacterium spp. and Porphyromonas spp. showed high sensitivities to many drugs. C. difficile was highly sensitive to vancomycin and metronidazole, having MIC90s of 0.5 μg/mL and ≤2 μg/mL, respectively. 相似文献