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291.
Jo JY Kim HL Lee YK Tomura H Bae YS Okajima F Im DS 《Journal of pharmacological sciences》2008,107(3):303-307
Calcium is a ubiquitous second messenger that controls a broad range of cellular functions, and store-operated calcium entry (SOCE) is the primary mechanism of regulated Ca(2+) entry in non-excitable immunocytes. In this study, we found that N,N-dimethyl-D-erythro-sphingosine (DMS) inhibited SOCE. In U937 cells, treatment with DMS for 2 h inhibited thapsigargin-induced SOCE by about 70%. DMS inhibited SOCE in a concentration-dependent manner when it was added to the cells after SOCE reached a plateau. DMS-induced SOCE inhibition was also confirmed by the Mn(2+)-quenching method, which monitors only Ca(2+) influx. Because sphingosine kinase inhibitors or protein kinase C (PKC) inhibitors could not mimic the SOCE inhibition, sphingosine kinase and PKC could be excluded as targets of DMS-induced inhibition of SOCE. Furthermore, disruption of lipid rafts with methyl-beta-cyclodextrin and bacterial sphingomyelinase did not influence DMS-induced inhibition of SOCE. DMS-induced inhibition of SOCE in U937 human monocytes is a unique observation and could serve as a basis to study modulation of intracellular Ca(2+) concentration by sphingolipids, although the precise mechanism should be elucidated in the future. 相似文献
292.
Kazumasa Shindo Michiaki Miwa Fumikazu Kobayashi Takamura Nagasaka Yoshihisa Takiyama 《Clinical autonomic research》2016,26(1):1-5
Purpose
To determine whether frontotemporal lobar degeneration (FTLD) is associated with similar cardiovascular autonomic dysfunction to that seen in amyotrophic lateral sclerosis (ALS), we compared cardiovascular parameters between ALS patients and patients with FTLD.Methods
In ten patients with FTLD (mean age ± SD: 71.6 ± 4.6 years) and 12 patients with ALS (mean age ± SD: 71.4 ± 4.6 years), MSNA (using microneurography), heart rate (HR), and blood pressure (BP) were recorded simultaneously.Results
MSNA was significantly higher in both groups of patients compared with the controls (p < 0.01), while there were no significant differences in MSNA between the patients with FTLD and those with ALS. During head-up tilt, changes in HR, BP, and the frequency of MSNA bursts were smaller in the patients than in controls (p < 0.05 or p < 0.01).Conclusions
Patients with FTLD and ALS showed similar dysfunction of HR, BP, and sympathetic outflow to muscles.293.
Kazumasa Shindo Mai Tsuchiya Nobuo Yamashiro Fumikazu Kobayashi Takamura Nagasaka Yoshihisa Takiyama 《Clinical autonomic research》2016,26(6):461-464
We recorded skin sympathetic nerve activity (SSNA), SSR, and SVR in 30 subjects. SSNA and SVR showed a slight decrease and spontaneous changes in resting SSR were significantly less frequent in older subjects compared with younger subjects (p < 0.05). There was no significant relationship between age and the reflex latency or amplitude of SSNA, SSR, and SVR in response to electrical stimulation. 相似文献
294.
Loss of skeletal muscle mass in patients with chronic liver disease is related to decrease in bone mineral density and exercise tolerance
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295.
Uchino Motoi Ikeuchi Hiroki Sugita Akira Futami Kitaro Watanabe Toshiaki Fukushima Kouhei Tatsumi Kenji Koganei Kazutaka Kimura Hideaki Hata Keisuke Takahashi Kenichi Watanabe Kazuhiro Mizushima Tsunekazu Funayama Yuji Higashi Daijiro Araki Toshimitsu Kusunoki Masato Ueda Takeshi Koyama Fumikazu Itabashi Michio Nezu Riichiro Suzuki Yasuo 《Journal of gastroenterology》2018,53(5):642-651
Journal of Gastroenterology - Although several complications capable of causing pouch failure may develop after restorative proctocolectomy (RPC) for ulcerative colitis (UC), the incidences and... 相似文献