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71.
72.
Clinicopathological features of gastric carcinoma in younger and middle-aged patients: A comparative study 总被引:2,自引:0,他引:2
Chikara Kunisaki M.D. Ph.D. Hirotoshi Akiyama M.D. Ph.D. Masato Nomura M.D. Goro Matsuda M.D. Yuichi Otsuka M.D. Hidetaka Andrew Ono M.D. Ph.D. Ryo Takagawa M.D. Yutaka Nagahori M.D. Ph.D. Masazumi Takahashi M.D. Ph.D. Fumihiko Kito M.D. Ph.D. Hiroshi Shimada M.D. Ph.D. 《Journal of gastrointestinal surgery》2006,10(7):1023-1032
Gastric carcinoma is relatively rare in patients under the age of 40. This study was undertaken to clarify the clinicopathological
characteristics and surgical outcomes of gastric carcinoma in younger patients compared with those of middle-aged patients.
The surgical results from 131 younger patients (aged ⩽40 years) and 918 middle-aged patients (aged 55–65 years) were compared
retrospectively. Female gender, undifferentiated tumor type and lymphatic invasion were significantly more common in the younger
patients. Survival time did not differ between the two groups. The depth of tumor invasion was the only prognostic factor
in younger patients, whereas macroscopic appearance, tumor diameter, depth of invasion, lymph node metastasis, and venous
invasion were all significant prognostic factors in middle-aged patients. Peritoneal recurrence was significantly more common
in younger patients. A family history of gastric adenocarcinoma was observed in 25.9% of younger patients, but this did not
affect survival outcomes. As depth of invasion affects prognosis independently, and peritoneal metastasis is the predominant
pattern of recurrence, it is essential to establish an optimal prophylactic treatment for peritoneal metastasis to improve
surgical outcomes in younger patients with advanced gastric cancer. 相似文献
73.
Kensuke Miyazaki Yasuhiro Torashima Satoshi Mochizuki Seiya Susumu Kengo Kanetaka Susumu Eguchi Takashi Kanematsu Kuniko Abe Fumihiko Fujita 《Surgery today》2014,44(3):581-585
Chronic idiopathic colonic pseudo-obstruction (CICP) is characterized by the chronic disturbance of colonic motility without mechanical obstruction, any underlying disease or medication. Currently, there are no established medical treatments for CICP. A 62-year-old female who had undergone right hemicolectomy for splenic flexure syndrome caused by idiopathic megacolon was referred to our hospital with relapse, experiencing palpitation and abdominal fullness. She was diagnosed with CICP according to findings of marked dilation of the colon without mechanical obstruction, dilation of other parts of the gastrointestinal tract, or underlying disease. The dilated colon was surgically removed by hand-assisted laparoscopic subtotal colectomy, followed by cecorectal anastomosis. Histopathologically, there was no degeneration or lack of ganglion cells in Auerbach’s plexus. The patient has experienced no severe symptoms after undergoing the present operation. 相似文献
74.
Flowcharts for the diagnosis and treatment of acute cholangitis and cholecystitis: Tokyo Guidelines 总被引:2,自引:0,他引:2
Miura F Takada T Kawarada Y Nimura Y Wada K Hirota M Nagino M Tsuyuguchi T Mayumi T Yoshida M Strasberg SM Pitt HA Belghiti J de Santibanes E Gadacz TR Gouma DJ Fan ST Chen MF Padbury RT Bornman PC Kim SW Liau KH Belli G Dervenis C 《Journal of Hepato-Biliary-Pancreatic Surgery》2007,14(1):27-34
Diagnostic and therapeutic strategies for acute biliary inflammation/infection (acute cholangitis and acute cholecystitis),
according to severity grade, have not yet been established in the world. Therefore we formulated flowcharts for the management
of acute biliary inflammation/infection in accordance with severity grade. For mild (grade I) acute cholangitis, medical treatment
may be sufficient/appropriate. For moderate (grade II) acute cholangitis, early biliary drainage should be performed. For
severe (grade III) acute cholangitis, appropriate organ support such as ventilatory/circulatory management is required. After
hemodynamic stabilization is achieved, urgent endoscopic or percutaneous transhepatic biliary drainage should be performed.
For patients with acute cholangitis of any grade of severity, treatment for the underlying etiology, including endoscopic,
percutaneous, or surgical treatment should be performed after the patient's general condition has improved. For patients with
mild (grade I) cholecystitis, early laparoscopic cholecystectomy is the preferred treatment. For patients with moderate (grade
II) acute cholecystitis, early laparoscopic or open cholecystectomy is preferred. In patients with extensive local inflammation,
elective cholecystectomy is recommended after initial management with percutaneous gallbladder drainage and/or cholecystostomy.
For the patient with severe (grade III) acute cholecystitis, multiorgan support is a critical part of management. Biliary
peritonitis due to perforation of the gallbladder is an indication for urgent cholecystectomy and/or drainage. Delayed elective
cholecystectomy may be performed after initial treatment with gallbladder drainage and improvement of the patient's general
medical condition. 相似文献
75.
Hiroaki Yokomori Fumihiko Kaneko Aya Sato Hajime Takeuchi Kumiko Tahara Tadashi Motoori Yasunobu Sekiguchi Shigehisa Mori Jun‐ichi Tamaru Toshifumi Hibi 《Hepatology research》2008,38(10):1054-1057
Hodgkin's lymphoma (HL) is in general a lymph node‐based disease. Hepatic involvement usually occurs in the advanced disease. Primary and prominent manifestation of the disease in the liver is extremely rare. We report magnetic resonance imaging leading to diagnosis in a rare case of liver involvement as the first sign of HL. 相似文献
76.
Takaaki Konuma Satoshi Takahashi Jun Ooi Akira Tomonari Nobuhiro Tsukada Seiko Kato Aki Sato Fumihiko Monma Senji Kasahara Tokiko Nagamura-Inoue Kaoru Uchimaru Tohru Iseki Arinobu Tojo Takuhiro Yamaguchi Shigetaka Asano 《Annals of hematology》2009,88(6):581-588
Increasing recipient age is a well-known risk factor for graft-versus-host disease (GVHD) and treatment-related mortality
(TRM) and has a negative impact on allogeneic hematopoietic stem cell transplantation. Since the incidence of severe GVHD
after cord blood transplantation (CBT) is lower than that after transplants using bone marrow or mobilized peripheral blood
grafts from adult cells, we should expect better outcomes from CBT in older patients. To evaluate the feasibility and efficacy
of myeloablative unrelated CBT in patients aged between 50 and 55 years, we performed a retrospective comparison of 100 patients
with acute leukemia who received cord blood grafts at our institution. Nineteen older patients (median age, 52; range, 50–55)
and 81 younger patients (median, 36; range, 16–49) received a myeloablative conditioning regimen including 12 Gy of total
body irradiation and chemotherapy. GVHD prophylaxis included cyclosporine with (n = 96) or without (n = 4) methotrexate. There were no significant differences in the incidences of grades II to IV acute GVHD, extensive-type
chronic GVHD, TRM, and the probability of overall and disease-free survival between these groups. These results suggest that,
in patients with acute leukemia, myeloablative CBT might be as safe and effective in patients aged between 50 and 55 years
as in younger patients. 相似文献
77.
Ryuta YASUDA Tetsu SATOW Naoki HASHIMURA Masaki NISHIMURA Jun C. TAKAHASHI Hiroharu KATAOKA 《Neurologia medico-chirurgica》2022,62(3):118
While endovascular coil embolization has become one of the major therapeutic modalities for intracranial aneurysms, long-term imaging follow-up is required because of the higher rate of retreatment compared with surgical clipping. The purpose of this study was to show the usefulness of craniograms to discriminate coiled intracranial aneurysms that required retreatment. Under the study protocol approved by institutional review board, a retrospective review of the medical record was done regarding coil embolization for intracranial aneurysms performed between January 2014 and December 2018. Coil embolization performed as the initial treatment and followed up for more than 1 year without additional treatment, and those performed as retreatment after the initial coil embolization performed at our institution were recruited. Craniograms obtained just after the initial treatment were compared with those obtained just before the additional treatment in the retreated cases and compared with the latest ones in the non-recurrence cases. Correlation between the morphological changes in the coil mass on the craniograms and retreatments was evaluated. During the study period, 288 coil embolization procedures for intracranial aneurysms were performed. From these, 191 treatments that were followed up for more than 1 year without any additional treatments and 30 retreatments were included. Morphological change of the coil mass was observed in 4 of the 191 non-recurrence treatments and 26 of the 30 retreatments, which was significantly correlated with retreatments (p <0.001). Craniogram was a useful modality in following up the coiled intracranial aneurysms to detect those required retreatments. 相似文献
78.
Masako Furuya-Yoshinaka Masaki Yoshinaka Fumihiko Isogai Yoshinobu Maeda 《Journal of prosthodontic research》2009,53(4):193-196
PurposeThis study aimed to examine how coverage of the hard palate by an experimental palatal plate influenced thermosensation.MethodsA total of 20 young adult volunteers were recruited from Osaka University Graduate School of Dentistry. An experimental palatal plate, 1.5 mm in thickness, was made for each subject from acrylic resin. The stimulus water were either warmed to 40, 42, 44, 46, or 48 °C or cooled to 30, 26, 22, 18, or 14 °C in a constant-temperature water bath, and the control water were maintained at 37 °C. Subjects were instructed to retain the control water in their mouths for 5 s, then to spit it out and to repeat with the stimulus water. They then rated the intensity of stimulation of warmth or cold compared to the control water by the magnitude estimation method. Each stimulus was administered three times in random order. Two experimental conditions were set: with and without the experimental palatal plate.ResultsPerceived thermal intensity was measured as the slope of the regression line for each condition (with or without the experimental palatal plate, cold or warmth). There was a significant difference between with and without the experimental palatal plate; the regression slope with the plate was shallower than that without the plate (warmth perception with plate = 0.55 ± 0.21 vs. warmth perception without plate = 0.70 ± 0.23, P < 0.05; cold perception with plate = –0.33 ± 0.14 vs. cold perception without plate = –0.39 ± 0.11, P < 0.05).ConclusionThe findings suggested that a denture covering the hard palate obstructs thermal perception. 相似文献
79.
Eiichiro Suzuki Tetsuhiro Chiba Yoh Zen Satoru Miyagi Motohisa Tada Fumihiko Kanai Fumio Imazeki Masaru Miyazaki Atsushi Iwama Osamu Yokosuka 《Hepatology research》2012,42(11):1100-1111
Aim: It has been reported that aldehyde dehydrogenase 1 A1 (ALDH1) could be not only a normal stem cell marker but also a cancer stem cell marker. ALDH1 expression could be a predictor of poor prognosis in a wide range of cancers. However, the role of ALDH1 in hepatocellular carcinoma (HCC) remains unclear. Method: We conducted loss‐of‐function assays for ALDH1 by using short‐hairpin RNA in HCC cells and evaluated the correlation between ALDH1 expression and clinicopathological features based on immunohistochemical assessment of 49 primary HCC tissues. Results: Neither cell proliferation nor the anchorage‐independent sphere formation ability of HCC cells were altered after ALDH1 knockdown. Flow cytometric analyses revealed that ALDH1 knockdown showed no remarkable change in the proportion of epithelial cell adhesion molecule (EpCAM)+ tumor‐initiating cells. Although non‐tumor tissues in primary HCC samples diffusely and homogenously expressed ALDH1 at low levels, tumor tissues contained cells with high levels of ALDH1 expression at varying frequencies. Primary HCC samples were categorized as ALDH1‐high or ALDH1‐low based on the percentage of ALDH1‐overexpressing cells. ALDH1‐high HCC was characterized by low serum levels of α‐fetoprotein (P < 0.01) and well‐differentiated pathology (P = 0.03). Multivariate analysis showed that high ALDH1 expression was a favorable prognostic factor in recurrence‐free survival of HCC (P = 0.02). Conclusion: Our findings show that ALDH1 expression has little association with stem cell‐like features in HCC cells. ALDH1 might function as a differentiation marker rather than a stem cell marker in HCC. 相似文献
80.
This study investigated HIV-related drug use and sexual behaviors among Japanese tourists in the Khaosan Road area in Bangkok, Thailand. A stratified sample of 150 Japanese tourists anonymously self-administered a structured questionnaire. Approximately two thirds of participants had used illicit drugs. Among drug users, 33% and 49% had used marijuana during the past 6 months in Japan and in Thailand, respectively. Study participants tended to engage in riskier sex in Japan than in Thailand. In Thailand, 9% had not always used condoms with sex workers for vaginal sex. The majority of participants had engaged in sex with sex workers under the influence of alcohol in Japan (88%) and in Thailand (71%). Those who had engaged in high-risk sexual behaviors in Japan were more likely to engage in the same behaviors in Thailand, and vice-versa. Drug abuse and HIV/AIDS prevention programs targeting young Japanese tourists should be established in Thailand. 相似文献