Über das Verhalten des wasserlöslichen Linseneiweißes junger und alter Tiere bei papierelektrophoretischer Untersuchung

Zusammenfassung Papierelektrophoretische Untersuchungen der wasserlöslichen Eiweißfraktionen von Linsen junger und alter Meerschweinchen und Kaninchen ergeben, daß mit dem Alter die Eiweißfraktionen I und II zunehmen, während die am langsamsten wandernde Fraktion III abnimmt. Ob diese altersbedingten Veränderungen im wasserlöslichen Eiweißgefüge der Linse darauf beruhen, daß die Linsenfasern, die postembryonal gebildet werden, andere Fermentanlagen zur Eiweißsynthese besitzen oder eine Umstimmung vorhandener Fermentaktivitäten erfahren, bedarf weiterer Untersuchungen.Mit 2 Textabbildungen     

The influence of maternal hypnosis on fetal movements in anxious pregnant women

The influence of maternal hypnotherapy on fetal body movements in anxious parturients was studied in 25 patients at 35-37 weeks of gestation. There were two groups of patients. Group A consisted of 16 parturients who performed self-hypnosis. Group B consisted of 9 parturients in whom hypnosis was induced by a physician. When compared to a control period of 30 min there was a significant increase in the duration of fetal body movements recorded by ultrasound during 30 min of maternal hypnosis, p less than 0.005 for group A and p less than 0.01 for group B. It is suggested that in anxious parturients fetuses move into a more active state when maternal relaxation is achieved by hypnotherapy.     

The influence of p-chlorophenylalanine on different morphine effects

p-Chlorophenylalanine (p-CPA) reduces brain 5-hydroxytryptamine (5-HT) without altering the dopamine and norepinephrine content. Morphine does not influence the 5-HT level, but partly reverses the depletion of 5-HT by p-CPA. Morphine analgesia and toxicity are not affected by p-CPA treatment. p-CPA also has no effect on acute morphine hypothermia, but after chronic treatment of 5-HT-deficient mice the dose--response curve is no longer parallel, which suggests that another mode of morphine hypothermia occurs. p-CPA diminishes morphine-induced running after acute as well as after chronic morphine administration. p-CPA treatment reduces the sensitivity to the naloxone-precipitated withdrawal reaction, but does not affect the development of physical dependence.     

Prognosis and long-term prognosis of epidural haematoma (a study of 83 patients) (author's transl)]

1. Early detection and treatment of epidural haematoma is vital to the chance of survival. In this respect physician's training needs to be improved. 2. The operation method of choice, particularly in the case of advanced midbrain lesions, is the extensive decompression operation (hemicranectomy) with duraplasty. In each case it is imperative to pay special attention to the relationship between blood pressure and brain perfusion until the state of decompressive is reached. 3. Late complications such as a disturbed circulation of the cerebrospinal fluid may occur and should be prevented by a shunt-operation. 4. ECG changes are still detectable even after many years. However, they give little indication on the patient's tendencies to fits. Post-traumatic cases of epilepsy may even occur more than five years after injury. 5. Patients suffering from epidural haematoma are in need of careful medical, psychiatric and social care for many years after injury, even if they seem to have been restored both neurologically and psychiatrically at the time of hospital discharge.     

Long-acting blood pressure reduction by candesartan cilexetil in patients with hypertension

Candesartan cilexetil is a highly potent and long-acting angiotensin II type I (AT1) receptor antagonist. This short review summarises results of clinical studies focusing on the duration of action of candesartan cilexetil. Results of previous clinical studies indicate that candesartan has the property to maintain a sustained blood pressure reduction for up to 48 h after dosing. Since lack of compliance is a known problem in patients with hypertension, these findings could be of particular clinical relevance.