Weitere Untersuchungen über die tetanigene Wirkung von Harnextrakten spasmophiler Säuglinge

Zusammenfassung Bei 12 weiteren Spasmophilien, also insgesamt an einem Material von 22 Spasmophilien, läßt sich ausnahmslos eine Substanz im Harn nachweisen, die nach subcutaner Injektion beim Kaninchen das von mir geschilderte Syndrom hervorruft (Calciumerniedrigung im Serum, elektrische Übererregbarkeit, Krämpfe, Exitus). Auch diesmal ergaben die Harnextrakte der Kontrollkinder (6 nach der Heilung untersuchte, vorher positive Spasmophilien) keinen nachweisbaren Substanzgehalt, keine klinischen Erscheinungen bei den gespritzten Tieren (insgesamt 17 Kontrollharne).Es wird somit die früher aufgestellte Theorie, daß die Säuglingsspasmophilie auf einer Überfunktion des lymphatischen Systems beruhe, durch das vergrößerte Untersuchungsmaterial weiter gestützt.Mit 1 Textabbildung.     

Reduced and Delayed Cerebrovascular Reactivity in Patients with Parkinson's Disease

Background

Cerebrovascular dysfunction in Parkinson's disease (PD) is heterogeneous and may contribute to disease pathophysiology or progression. There is a need to understand the mechanisms by which cerebrovascular dysfunction is altered in participants with PD.

Objectives

The objective of this study is to test the hypothesis that participants with PD exhibit a significant reduction in the ability of the cerebral vessels to dilate in response to vasoactive challenges relative to healthy controls (HC).

Methods

The current study uses a vasodilatory challenge while participants undergo functional magnetic resonance imaging to quantify the amplitude and delay of cerebrovascular reactivity in participants with PD relative to age and sex-matched HC. An analysis of covariance was used to evaluate differences in cerebrovascular reactivity amplitude and latency between PD participants and HC.

Results

A significant main effect of group was observed for whole-brain cerebrovascular reactivity amplitude (F_{(1, 28)} = 4.38, p = 0.046, Hedge's g = 0.73) and latency (F_{(1, 28)} = 16.35, p < 0.001, Hedge's g = 1.42). Participants with PD exhibited reduced whole-brain amplitude and increased latencies in cerebrovascular reactivity relative to HC. The evaluation of regional effects indicates that the largest effects were observed in the cuneus, precuneus, and parietal regions.

Conclusions

PD participants exhibited reduced and delayed cerebrovascular reactivity. This dysfunction may play an important role in chronic hypoxia, neuroinflammation, and protein aggregation, mechanisms that could lead to disease progression. Cerebrovascular reactivity may serve as an important biomarker and target for future interventions. © 2023 The Authors. Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.