全文获取类型
收费全文 | 4448篇 |
免费 | 437篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 32篇 |
儿科学 | 91篇 |
妇产科学 | 109篇 |
基础医学 | 524篇 |
口腔科学 | 74篇 |
临床医学 | 445篇 |
内科学 | 864篇 |
皮肤病学 | 55篇 |
神经病学 | 237篇 |
特种医学 | 128篇 |
外科学 | 671篇 |
综合类 | 158篇 |
预防医学 | 450篇 |
眼科学 | 187篇 |
药学 | 338篇 |
中国医学 | 96篇 |
肿瘤学 | 460篇 |
出版年
2023年 | 41篇 |
2022年 | 53篇 |
2021年 | 96篇 |
2020年 | 66篇 |
2019年 | 112篇 |
2018年 | 98篇 |
2017年 | 87篇 |
2016年 | 86篇 |
2015年 | 130篇 |
2014年 | 153篇 |
2013年 | 183篇 |
2012年 | 268篇 |
2011年 | 265篇 |
2010年 | 178篇 |
2009年 | 172篇 |
2008年 | 270篇 |
2007年 | 274篇 |
2006年 | 234篇 |
2005年 | 263篇 |
2004年 | 205篇 |
2003年 | 208篇 |
2002年 | 164篇 |
2001年 | 115篇 |
2000年 | 116篇 |
1999年 | 115篇 |
1998年 | 54篇 |
1997年 | 49篇 |
1996年 | 32篇 |
1995年 | 26篇 |
1994年 | 32篇 |
1993年 | 23篇 |
1992年 | 86篇 |
1991年 | 75篇 |
1990年 | 70篇 |
1989年 | 51篇 |
1988年 | 62篇 |
1987年 | 62篇 |
1986年 | 45篇 |
1985年 | 40篇 |
1984年 | 25篇 |
1983年 | 26篇 |
1982年 | 27篇 |
1981年 | 17篇 |
1979年 | 18篇 |
1978年 | 15篇 |
1977年 | 11篇 |
1976年 | 17篇 |
1974年 | 12篇 |
1972年 | 12篇 |
1970年 | 11篇 |
排序方式: 共有4919条查询结果,搜索用时 15 毫秒
71.
Nancy Kemeny William Jarnagin Philip Paty Mithat G?nen Lawrence Schwartz Mero? Morse Gregory Leonard Michael D'Angelica Ronald DeMatteo Leslie Blumgart Yuman Fong 《Journal of clinical oncology》2005,23(22):4888-4896
PURPOSE: To determine the maximum-tolerated dose (MTD) of concurrent systemic oxaliplatin (Oxal) combinations plus hepatic arterial infusion (HAI) in patients with unresectable hepatic metastases from colorectal cancer. PATIENTS AND METHODS: Thirty-six patients (89% previously treated) with unresectable liver metastases were treated with concurrent HAI and systemic Oxal plus irinotecan (CPT-11; group A) or Oxal, fluorouracil (FU), and leucovorin (LV; group B). Systemic chemotherapy was administered every 2 weeks concurrent with 2 weeks of HAI floxuridine (FUDR) and dexamethasone (Dex) every 28 days. RESULTS: The MTD for patients in group A was Oxal 100 mg/m(2), CPT-11 150 mg/m(2), and FUDR 0.12 mg/kg x 30 mL divided by pump flow rate. The MTD for group B was Oxal 100 mg/m(2), LV 400 mg/m(2), and FU 1,400 mg/m(2) by continuous infusion over 48 hours, with the same FUDR dose as in group A. Grade 3 or 4 toxicities in groups A and B included diarrhea (24% and 20%), neutropenia (10% and 7%), neurotoxicity (24% and 20%), and bilirubin more than 3 mg/mL (5% and 7%, respectively). The complete and partial response rate totaled 90% for group A and 87% for group B. Median survival time was 36 and 22 months for groups A and B, respectively. Seven patients in group A were ultimately able to undergo liver resection. CONCLUSION: Combination therapy with HAI FUDR and Dex plus systemic Oxal combinations may be safely administered to patients with colorectal cancer. The high response rate (88%) and the possibility of conversion to resectability, despite disease progression on prior systemic regimens, suggest that these combinations should be evaluated in larger studies as first- or second-line therapy in patients with hepatic metastases from colorectal cancer. 相似文献
72.
73.
74.
75.
Kanako J. Nagatomo Kevin A. Tompkins Hanson Fong Hai Zhang Brian L. Foster Emily Y. Chu 《Connective tissue research》2013,54(6):391-400
Bone morphogenetic proteins (BMPs) and BMP antagonists play a crucial role in the regulation of tooth development. One of the BMP extracellular antagonists, gremlin, is a highly conserved 20.7-kDa glycoprotein. Previously, researchers reported that transgenic mice overexpressing gremlin under the control of the osteocalcin promoter (gremlin OE) exhibit a skeletal phenotype and tooth fragility. To further define the tooth phenotype, teeth and surrounding supporting tissues, obtained from gremlin OE at ages of 4 weeks, 2 months, and 4 months, were examined. The histological results demonstrate that gremlin OE exhibit an enlarged pulp chamber with ectopic calcification and thinner dentin and enamel compared with wild-type control. In vitro studies using murine pulp cells revealed that gremlin inhibited BMP-4 mediated induction of Dspp. These data provide evidence that balanced interactions between BMP agonists/antagonists are required for proper development of teeth and surrounding tissues. It is clear that these interactions require further investigation to better define the mechanisms controlling tooth root formation (pulp, dentin, cementum, and surrounding tissue) to provide the information needed to successfully regenerate these tissues. 相似文献
76.
77.
78.
SB Cho JH Kim S Cho JM Park YK Park SH Oh 《Journal of the European Academy of Dermatology and Venereology》2011,25(1):64-67
Background The clinical characteristics of vitiligo in children and adolescents with an emphasis on thyroid dysfunction have only been reported in a few studies. Objective The purpose of this study was to examine the characteristics of children and adolescents with vitiligo and compare the incidence of thyroid dysfunction between them and controls without vitiligo at the same age. Methods A retrospective analysis of 324 Korean children and adolescents with vitiligo was performed. The results of thyroid function screening tests in them (n = 254) were compared with controls (n = 122). Results Of the total 324 children and adolescents with vitiligo, vitiligo vulgaris was the most common type (42.3%) and the most commonly involved site was the face (54.6%). A total of 15 of 254 (5.9%) patients screened for thyroid function were diagnosed with thyroid disease (four had Hashimoto’s thyroiditis; two, Graves’ disease; seven, subclinical hypothyroidism; and two, subclinical hyperthyroidism). None of the 50 patients with segmental vitiligo showed any thyroid dysfunction (P = 0.047). There was no significant difference in the incidence of thyroid disease between children and adolescents with vitiligo and the control group, in which seven of 122 (5.7%) showed thyroid dysfunction. Conclusion In this study, we demonstrated the characteristics of children and adolescents with vitiligo and also observed no significant difference in the incidence of thyroid disease between children and adolescents with vitiligo and the control group. 相似文献
79.
Yanghee Woo Carolyn E. Behrendt Annie Yang Maria Hahn Ajay Goel Haiqing Li Yate-Ching Yuan Yuman Fong 《Journal of the American College of Surgeons》2021,232(4):483-491.e1
- Download : Download high-res image (292KB)
- Download : Download full-size image
80.