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101.
Mahender Nath Avula Archana Nagaraja Rao Lawrence D. McGill David William Grainger Florian Solzbacher 《Biomaterials》2013
The host foreign body response (FBR) adversely effects the performance of numerous implanted biomaterials especially biosensors, including clinically popular glucose-monitoring sensors. Reactive formation of a fibrous capsule around implanted sensors hinders the transport of essential analytes to the sensor from the surrounding tissue, resulting in loss of glucose response sensitivity and eventual sensor failure. Several strategies have sought to mitigate the foreign body response's effects on CGM sensors through the use of local delivery of pharmaceuticals and biomolecules with limited success. This study describes release of a tyrosine kinase inhibitor – masitinib – from the sensor implant to target tissue resident mast cells as key mediators of the FBR. Model implants are coated with a composite polymer hydrophilic matrix that rapidly dissolves upon tissue implantation to deposit slower-degrading polymer microparticles containing masitinib. Matrix dissolution limits coating interference with sensor function while establishing a local controlled-release delivery depot formulation to alter implant tissue pharmacology and addressing the FBR. Drug efficacy was evaluated in a murine subcutaneous pocket implant model. Drug release extends to more than 30 days in vitro. The resulting FBR in vivo, evaluated by implant capsule thickness and inflammatory cell densities at 14, 21, and 28 days, displays statistically significant reduction in capsule thickness around masitinib-releasing implant sites compared to control implant sites. 相似文献
102.
Paula E. Florian Alina Macovei Catalin Lazar Adina L. Milac Izabela Sokolowska Costel C. Darie Robert W. Evans Anca Roseanu Norica Branza‐Nichita 《Journal of medical virology》2013,85(5):780-788
Lactoferrin (Lf) was shown to exhibit its antiviral activity at an early phase of viral infection and a mechanism whereby the protein interacts with host cell surface molecules has been suggested. In this study, human Lf (HLf) and seven HLf‐derived synthetic peptides (HLP) corresponding to the N‐terminal domain of the native protein (1–47 amino acids sequence) were assayed for their capacity to prevent hepatitis B virus (HBV) infection and replication using the HepaRG and HepG2.2.2.15 cell lines. Of the series tested, four peptides showed 40–75% inhibition of HBV infection in HepaRG cells, HLP1–23, containing the GRRRR cationic cluster, being the most potent. Interestingly, this cluster is one of the two glycosaminoglycan binding sites of the native HLf involved in its antiviral activity; however, the mechanism of the HLP1–23 action was different from that of the full‐length protein, the peptide inhibiting HBV infection when pre‐incubated with the virus, while no effect was observed on the target cells. It is suggested that the cationic cluster is sufficient for the peptide to interact stably with negatively charged residues on the virion envelope, while the absence of the second glycosaminoglycan binding site prevents its efficient attachment to the cells. In conclusion, this peptide may constitute a non‐toxic approach for potential clinical applications in inhibiting HBV entry by neutralizing the viral particles. J. Med. Virol. 85:780–788, 2013. © 2013 Wiley Periodicals, Inc. 相似文献
103.
Scharpf Florian Mkinga Getrude Masath Faustine Bwire Hecker Tobias 《European child & adolescent psychiatry》2021,30(10):1651-1662
European Child & Adolescent Psychiatry - Children and adolescents’ mental health risk and resilience arise from a complex interplay of factors on several socio-ecological levels. However,... 相似文献
104.
Comments on “Evaluation and review of ways to differentiate sources of ethanol in post-mortem blood”
Hakim Florian Gicquel Thomas Allorge Delphine Gaulier Jean-michel 《International journal of legal medicine》2021,135(4):1477-1479
International Journal of Legal Medicine - 相似文献
105.
Stoecklein Veit Michael Kellert Lars Patzig Maximilian Küpper Clemens Giese Armin Ruf Viktoria Weller Jonathan Kreth Friedrich-Wilhelm Schöberl Florian 《Journal of neurology》2021,268(1):367-376
Journal of Neurology - To evaluate the diagnostic accuracy and safety of extended stereotactic brain biopsy (ESBB) in a single center cohort with suspected primary angiitis of the central nervous... 相似文献
106.
Carla Palleis MD Julia Sauerbeck Leonie Beyer MD Stefanie Harris Julia Schmitt Estrella Morenas-Rodriguez PhD Anika Finze Alexander Nitschmann Francois Ruch-Rubinstein Florian Eckenweber Gloria Biechele Tanja Blume MSc Yuan Shi PhD Endy Weidinger MD Catharina Prix MD Kai Bötzel MD Adrian Danek MD Boris-Stephan Rauchmann MD Sophia Stöcklein MD Simon Lindner PhD Marcus Unterrainer MD Nathalie L. Albert MD Christian Wetzel PhD Rainer Rupprecht MD Axel Rominger MD Peter Bartenstein MD Jochen Herms MD Robert Perneczky MD Christian Haass PhD Johannes Levin MD Günter U. Höglinger MD Matthias Brendel MD 《Movement disorders》2021,36(4):883-894
107.
Rogier Thomas Eberl Isabelle Moretto Florian Sixt Thibault Catherine François-Xavier Estève Clémentine Abdallahoui Maroua Behague Lucile Coussement Antoine Mathey Lucas Mahy Sophie Buisson Marielle Salmon-Rousseau Arnaud Duong Michel Chavanet Pascal Bernard Quentin Nicolas Barbara Benguella Leila Bonnotte Bernard Blot Mathieu Piroth Lionel 《European journal of clinical microbiology & infectious diseases》2021,40(9):2023-2028
European Journal of Clinical Microbiology & Infectious Diseases - During an epidemic period, we compared patients hospitalized for initial suspicion of COVID-19 but for whom an alternative... 相似文献
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