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951.
952.
Ver?nica Riquet de Siqueira Aline Salmito Frota Israel Leit?o Maia Hercília Maria Carvalho Queiroz Jose Telmo Valen?a Júnior José Wilson Accioly Filho 《Anais brasileiros de dermatologia》2014,89(6):960-963
Cutaneous metastasis is an uncommon manifestation of visceral malignancy. It occurs
late in the course of the disease but can be a sign of an unknown neoplasm. A case of
local cutaneous metastasis by contiguity with breast adenocarcinoma is reported. It
presented as initial manifestation and main complaint of a 68-year-old woman, with no
family history and negative screening tests for the disease. Biopsies of ulcers which
do not heal, persistent hardened erythema and cutaneous nodules of unknown cause must
be performed, since the evidence of cutaneous metastasis can be of extreme importance
for the diagnosis, staging and prognosis of an internal cancer. In this scenario, the
dermatologist plays a fundamental role and should be always attentive to this
diagnostic possibility. 相似文献
953.
Daíne Vargas Couto Gunter Hans Filho Marcelo Zanolli Medeiros Carolina Faria Santos Vicari Aline Blanco Barbosa Luiz Carlos Takita 《Anais brasileiros de dermatologia》2014,89(6):974-976
American Tegumentary Leishmaniasis (ATL) is a chronic, non-contagious, infectious
disease affecting millions of people worldwide. The timely and proper treatment is of
great importance to prevent the disease from progressing to destructive and severe
forms. Treatment for ATL recommended by the Brazilian Ministry of Health is similar
for the whole country, regardless of the species of Leishmania. It
is known that the response to treatment may vary with the strain of the parasite, the
immune status of the patient and clinical form. We report the case of a healthy
patient, coming from Manaus, Amazonas state, Brazil, who presented resistance to
treatment with N-methyl-glutamine and liposomal amphotericin B, only being healed
after using pentamidine. 相似文献
954.
955.
Hélio Antonio Guimarães Filho Rosiane Mattar Edward Araujo Júnior Lavoisier Linhares Dias da Costa Carlos Fernando de Mello Junior Luciano Marcondes Machado Nardozza Paulo Martin Nowak Antonio Fernandes Moron 《Archives of gynecology and obstetrics》2011,283(2):213-217
Purpose
Assess intra and interobserver reproducibility of three-dimensional power Doppler (3DPD) placental vascular indices in normal pregnancies between 26 and 35 weeks. 相似文献956.
Luis G. C. Nicolau Wellington P. Martins Francisco M. P. Gallarreta Jailson C. Lima Francisco Mauad Filho 《Archives of gynecology and obstetrics》2011,284(2):313-317
Purpose
To evaluate the effect of pregnancy and smoking on endothelial function using brachial artery flow-mediated dilation (FMD) and to determine the time necessary until the occurrence of maximum brachial artery dilation after stimulus. 相似文献957.
Zanvettor PH Filho DF Neves AR Amorim MJ Medeiros SM Laranjeiras LC Morais JA Araujo IO Barbosa HS 《Gynecologic oncology》2011,120(3):358-361
Introduction and objectives
Cervical cancer incidence worldwide is about 500,000 new cases per year with most of them being detected at a locally advanced stage. Many studies have shown the need to look for extra-pelvic disease when planning appropriate therapy. We performed surgical staging by laparoscopy in 43 cases of cervical cancer at stages IB2 to IVa and evaluated our initial results.Materials and methods
Between February 2008 and May 2010, we selected 43 patients with histologically confirmed cervical cancer at stages IB2 to IVA with a Karnosfsky index > 70. We classified the tumors according to the FIGO (International Federation of Gynecology and Obstetrics) stage and performed tomographic evaluations of the abdomen to select patients without signs of peritoneal or para-aortic tumor spread. We performed a laparoscopic evaluation of the peritoneal cavity and para-aortic lymph nodes by an extra-peritoneal route. We did not use tweezers or disposable energy seals.Results
The mean surgical time was 130.8 min. The mean blood loss was 111.5 ml. There was no conversion to laparotomy for any case. We describe a case with peritoneal implants that was classified as IVB.We removed an average of 16.4 lymph nodes; nine cases had para-aortic lymph node metastases.Conclusion
Laparoscopic surgical staging diagnosed 23.3% of cases with peritoneal spread of the tumor or extra-pelvic lymph node metastases. In this study, we could better define the lymph node status through laparoscopic surgical staging and could therefore recommend more suitable adjuvant therapy for patients with locally advanced cervical cancer. 相似文献958.
959.
Bordignon Nunes F Meier Graziottin C Alves Filho JC Lunardelli A Caberlon E Peres A Rodrigues De Oliveira J 《International immunopharmacology》2003,3(2):267-272
Sepsis remains an important and life-threatening problem, and is the most common cause of death in the intensive care unit. One promising therapeutic candidate for protection against injury in sepsis is fructose-1,6-bisphosphate (FBP), a high-energy glycolytic pathway intermediate. The objective of the study was to establish a role for FBP on the immune system, especially in lymphocyte proliferation. Peripheral blood mononuclear cells (PBMCs) were isolated from the blood of healthy humans by gradient centrifugation. T-lymphocytes were stimulated for 96 h with phytohemagglutinin (PHA) and varying concentration of FBP. Fructose-1,6-bisphosphate at concentrations between 1.2 and 10 mM decreased proliferation of T-lymphocytes and reduced the viability only at concentrations 5.0 and 10 mM. The levels of soluble IL-2 receptor were reduced at FBP concentrations between 1.2 and 10 mM. In conclusion, this study demonstrates that FBP has important effect on immunomodulatory and this result can be correlated with the protection against injury in sepsis. 相似文献
960.
F. PEYVANDI R. PALLA M. MENEGATTI S. M. SIBONI S. HALIMEH B. FAESER H. PERGANTOU H. PLATOKOUKI P. GIANGRANDE K. PEERLINCK T. CELKAN N. OZDEMIR C. BIDLINGMAIER J. INGERSLEV M. GIANSILY‐BLAIZOT J. F. SCHVED R. GILMORE A. GADISSEUR M. BENEDIK‐DOLNIAR L. KITANOVSKI D. MIKOVIC K. M. MUSALLAM F. R. ROSENDAAL 《Journal of thrombosis and haemostasis》2012,10(4):615-621
Summary. Background: The European Network of Rare Bleeding Disorders (EN‐RBD) was established to bridge the gap between knowledge and practise in the care of patients with RBDs. Objectives: To explore the relationship between coagulation factor activity level and bleeding severity in patients with RBDs. Patients/Methods: Cross‐sectional study using data from 489 patients registered in the EN‐RBD. Coagulation factor activity levels were retrieved. Clinical bleeding episodes were classified into four categories according to severity. Results: The mean age of patients at data collection was 31 years (range, 7 months to 95 years), with an equal sex distribution. On linear regression analysis, there was a strong association between coagulation factor activity level and clinical bleeding severity for fibrinogen, factor (F) X, FXIII, and combined FV and FVIII deficiencies. A weaker association was present for FV and FVII deficiencies. There was no association between coagulation factor activity level and clinical bleeding severity for FXI. The coagulation factor activity levels that were necessary for patients to remain asymptomatic were: fibrinogen, > 100 mg dL?1; FV, 12 U dL?1; combined FV + VIII, 43 U dL?1; FVII, 25 U dL?1; FX, 56 U dL?1; FXI, 26 U dL?1; FXIII, 31 U dL?1. Moreover, coagulation factor activity levels that corresponded with Grade III bleeding were: undetectable levels for fibrinogen, FV and FXIII, < 15 U dL?1 for combined FV + VIII; < 8 U dL?1 for FVI; < 10 U dL?1 for FX; and < 25 U dL?1 for FXI. Conclusions: There is a heterogeneous association between coagulation factor activity level and clinical bleeding severity in different RBDs. A strong association is only observed in fibrinogen, FX and FXIII deficiencies. 相似文献