针刺治疗高胆固醇血症临床观察

目的评价针刺与药物(洛伐他丁)治疗高胆固醇血症的疗效及安全性。方法将150例高胆固醇血症患者分成3组,针刺治疗组50例,药物(洛伐他汀)治疗组50例,针刺加药物治疗组50例,以中医理论为指导,对针刺治疗高胆固醇血症进行临床观察。结果在观察150例中,总有效率均在80%以上,针刺治疗与药物治疗组疗效相似(P0.05),但针刺+药物组疗效高于其他两组(P0.05)。结论针刺治疗高胆固醇血症有效,且无副作用,值得临床推广运用。     

Treatment and prognostic factors of papillary thyroid microcarcinoma

Clin. Otolaryngol. 2010, 35 , 118–124 Objective: To discuss the prognostic factors and outcomes of treatment in patients diagnosed with papillary thyroid microcarcinoma. Design: Retrospective observational case review. Setting: Department of Otorhinolaryngology of the tertiary referral teaching hospital of Parma. Participants: Ninety-seven patients diagnosed with PTMC and surgically treated between January 1998 and December 2007. Main outcome measures: Clinical and histopathological characteristics of the study group were identified and statistically analysed. Results: No cancer-related deaths were registered. Incidence of recurrent disease was 9% after a 43 month mean follow-up (range 12–120). Univariate analysis detected that metastases in neck lymph nodes at diagnosis (p = 0.025), a tumour >5 mm in size (p = 0.011), the presence of bilateral tumoural foci (p = 0.007), the presence of capsular invasion (p = 0.001), and the presence of vascular invasion (p = 0.004) were related to recurrent disease. On multivariate analysis, the presence of bilateral tumoural foci (p = 0.030), and the presence of capsular invasion (p = 0.005) were significantly related to tumour recurrence. Conclusion: The prognosis for patients with papillary thyroid microcarcinoma in this series was excellent, with a 100% survival rate and minimal surgical-related morbidity. Nevertheless, approximately 10% of patients developed recurrent disease; aggressive treatment may be justified depending on the presence or absence of prognostic risk factors.     

夏季修剪和冬季修剪对金银花产量和生长的影响研究

通过安排田间小区试验,研究了金银花生长前3年,夏季修剪和冬季修剪对金银花早期产量和生长的影响。通过分析,夏季修剪对地径增粗的影响较小;在金银花定植的第1年,进行过重的夏季修剪不仅不能增加地径粗度,反而有相反作用,冬季修剪对地径增粗影响显著,即冬季修剪可使金银花主干增粗。相对于不修剪,较轻的夏季修剪和冬季修剪均可显著提高九丰1号金银花植株高度,减少发枝数并缩减冠幅;相对于轻剪,较重的修剪使树体被过度削弱,使株高降低、发枝数减少。夏季修剪和冬季修剪均对产量有影响,但冬季修剪对产量的影响更显著,在金银花定植早期(第2年)修剪会使金银花产量降低,且重剪降低程度甚于轻剪,但是当植株生长到第3年,合理的修剪可有效增加金银花产量,且三年产量总和最高。研究表明,金银花早期最为合理的增产修剪方案为冬季轻剪和夏季轻剪处理。     

Successful control of methicillin‐resistant Staphylococcus aureus outbreak at a university department of dermatology

Background Methicillin‐resistant Staphylococcus aureus (MRSA) is one of the leading strains among multiresistant hospital microflora. In 2003, we noted an increase in the number of MRSA strain 35 among patients at the University of Zurich, Department of Dermatology. At the end of 2003, we implemented additional policies in hospital hygiene, which significantly decreased the number of MRSA infections. Methods This is a retrospective study on 65 consecutive patients at the Department of Dermatology, University Hospital of Zurich, in whom MRSA contamination was newly diagnosed during the period of 2003–2008. All isolated strains were genotyped. We implemented additional policies as strict hand hygiene and avoidance of sharing the same ointment pots or tubes amongst patients. As soon as the skin disease was healed, decolonization of MRSA was undertaken by a 5‐day topical treatment. Results Of the 65 MRSA patients, 19 (29%) patients carried a genotypical strain (MRSA 35) that was identified to be specific for the Department of Dermatology. Three health care workers (HCWs) were tested positive. The outlined measures reduced the incidence of new transmissions of this specific strain MRSA 35 significantly (P = 0.001) with a complete disappearance of new transmissions of MRSA 35 in the year 2008. Of the 65 patients, 15 (23%) patients became long‐term carriers, among all (15/15; 100%) had persisting active skin lesions. Conclusions Strict hand hygiene and avoidance of sharing ointments among patients were highly effective measures in controlling an outbreak of MRSA. Complete of near‐to‐complete remission of the underlying dermatoses, skin lesions or chronic wounds, is a prerequisite for complete decolonization of MRSA carriers.     

外源核苷酸对肉鸡生产性能的影响

研究了天然日粮中补充外源核苷酸对肉仔鸡胃肠道等消化器官及生产性能的影响 .0～ 14日龄爱维因肉仔鸡按体重随机分成 4组 ,每组 4个重复 ,分别饲喂玉米豆饼无鱼粉基础日粮 ( 1组 ) ,基础日粮中添加 0 .0 5%核酸 ( 2组 )、0 .1%核酸 ( 3组 )以及基础日粮中含 2 %鱼粉 ( 4组 ) .结果表明 ,第 2 ,3,4组的肉仔鸡 14日龄生长速度比对照组提高 14%～ 17% ,饲料利用率提高 4 %～6% .2、3组鸡 4日龄十二指肠质量、3组鸡空肠质量、胰腺质量显著高于对照组 (P <0 .0 5) ;7日龄小肠粘膜的蛋白酶活性也极显著高于对照组 (P <0 .0 1) .研究表明 ,日粮中添加外源核苷酸对提高肉仔鸡生长速度、胃肠道、胰脏质量、肠粘膜蛋白酶活性均有重要的影响 .     

Non-linear EEG analysis in children with epilepsy and electrical status epilepticus during slow-wave sleep (ESES)

OBJECTIVE: The objective of this work was to study the non-linear aspects of electroencephalography (EEG) in children with epilepsy and electrical status epilepticus during slow-wave sleep (ESES). METHODS: In this study, we recorded the sleep EEG in 5 subjects with ESES (4 males and one female, aged 6.5-10 years) who were also mentally retarded and affected by cerebral palsy (3 subjects) and hydrocephalus (two subjects). The signals were sampled at 128Hz and stored on hard disk. All the subsequent computational steps were performed on EEG epochs (4096 data points) selected from wakefulness and non-rapid eye movement (non-REM) (with ESES) or REM sleep. The dynamic properties of the EEG were assessed by means of the non-linear cross prediction (NLCP) test which uses 3 different 'model' time series in order to predict non-linearly the original data set (Pred, Ama and Tir). Pred is a measure of the predictability of the time series and Ama and Tir are measures of asymmetry, indicating non-linear structure. Moreover, the correlation dimension (D2) was estimated by means of the algorithm by for the epochs showing non-linear nature. RESULTS: The NLCP test provided evidence of significant non-linear dynamics in all epochs of non-REM sleep, when ESES was evident. Only during this stage, the possible presence of low-dimensional chaos could also be suspected (average D2=4.02; range 3.16-6.21). EEG without ESES could not be distinguished from linearly filtered noise. CONCLUSIONS: The results of the present study seem to indicate that subjects with ESES show a profound modification of their EEG dynamics with the occurrence, during sleep, of long periods characterized by non-linear dynamics and, probably, low-dimensional chaotic structure able to modify in a substantial way their brain functioning during sleep.