全文获取类型
收费全文 | 5616篇 |
免费 | 339篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 106篇 |
儿科学 | 110篇 |
妇产科学 | 148篇 |
基础医学 | 881篇 |
口腔科学 | 698篇 |
临床医学 | 448篇 |
内科学 | 1057篇 |
皮肤病学 | 173篇 |
神经病学 | 405篇 |
特种医学 | 78篇 |
外科学 | 525篇 |
综合类 | 17篇 |
一般理论 | 2篇 |
预防医学 | 588篇 |
眼科学 | 50篇 |
药学 | 454篇 |
中国医学 | 53篇 |
肿瘤学 | 188篇 |
出版年
2024年 | 12篇 |
2023年 | 94篇 |
2022年 | 176篇 |
2021年 | 270篇 |
2020年 | 177篇 |
2019年 | 250篇 |
2018年 | 272篇 |
2017年 | 199篇 |
2016年 | 220篇 |
2015年 | 242篇 |
2014年 | 309篇 |
2013年 | 366篇 |
2012年 | 503篇 |
2011年 | 589篇 |
2010年 | 283篇 |
2009年 | 221篇 |
2008年 | 343篇 |
2007年 | 316篇 |
2006年 | 259篇 |
2005年 | 239篇 |
2004年 | 198篇 |
2003年 | 137篇 |
2002年 | 124篇 |
2001年 | 13篇 |
2000年 | 10篇 |
1999年 | 9篇 |
1998年 | 15篇 |
1997年 | 16篇 |
1996年 | 6篇 |
1995年 | 16篇 |
1994年 | 9篇 |
1993年 | 5篇 |
1992年 | 6篇 |
1991年 | 6篇 |
1990年 | 7篇 |
1988年 | 8篇 |
1987年 | 6篇 |
1986年 | 4篇 |
1985年 | 5篇 |
1984年 | 2篇 |
1983年 | 3篇 |
1982年 | 8篇 |
1981年 | 2篇 |
1980年 | 4篇 |
1979年 | 4篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 2篇 |
1971年 | 3篇 |
1931年 | 1篇 |
排序方式: 共有5981条查询结果,搜索用时 0 毫秒
41.
Kamila Pires de Carvalho Mariana Tavares Miranda Lima Fernanda Silva Mazzutti Isis Danyelle Dias Custódio Paula Philbert Lajolo Canto Carlos Eduardo Paiva Yara Cristina de Paiva Maia 《Clinical breast cancer》2019,19(1):e208-e219
Purpose
To study the use of functional capacity (FC) level and duration of aromatase inhibitor (AI) therapy with adiposity parameters in women with breast cancer.Patients and Methods
FC was evaluated through the Health Assessment Questionnaire, which was assessed by classification and divided into 3 groups: G1 = mild to moderate difficulty, G2 = moderate to severe disability, and G3 = severe or very severe disability. Body mass, height, and waist circumference (WC) were measured, and body mass index (BMI) was calculated. Bioelectrical impedance analysis was used to calculate body fat (BF) and fat-free mass. The women were divided into 2 time groups (T1 and T2), which were determined by the median months of AI use (T1 ≤ 29.5 and T2 > 29.5 months).Results
Impaired FC and adiposity parameters were significantly positively correlated. In addition, physical exercise was significantly lower in women assessed as G2 and G3 compared to those assessed as G1. The effect of FC on BMI, BF, and WC was also verified, as was the effect of the duration of AI receipt on BMI and BF. Women at T1 had significantly greater functional disability, BMI, and BF values. In addition, although not statistically significant, women in T1 who were assessed as G3 presented higher BMI, WC, and BF values than those in T2.Conclusion
Adiposity above the recommended parameters and impaired FC were associated with the shortest time of receipt of adjuvant endocrine therapy with AI. 相似文献42.
Marlon E. Cerf Charna S. Chapman Christo J. Muller Johan Louw 《Metabolism: clinical and experimental》2009,58(12):1787-1792
Hyperglycemia and compromised β-cell development were demonstrated in neonatal rats programmed with a gestational high-fat diet. The aim of this study was to determine whether these changes were attributed to impaired insulin release and altered immunoreactivity of Pdx-1, glucokinase (GK), and glucose transporter (GLUT)–2 in high-fat–programmed neonates. Fetuses were maintained, via maternal nutrition, on either a standard laboratory diet (control) or a high-fat diet throughout gestation (HFG). Pancreata from 1-day–old neonates were excised for islet isolation and the subsequent measurement of insulin release at 2.8, 6.5, 13, and 22 mmol/L glucose. Other pancreata were either snap frozen for quantitative polymerase chain reaction or formalin fixed for immunohistochemistry followed by image analysis. The HFG neonates had reduced insulin release at 13- and 22-mmol/L glucose concentrations. No significant differences were found in Pdx-1, GK, or GLUT-2 messenger RNA expression. In HFG neonates, immunoreactivity of both Pdx-1 and GK was significantly reduced, with a nonsignificant reduction in GLUT-2. Gestational high-fat programming impairs insulin release and reduces Pdx-1 and GK immunoreactivity. 相似文献
43.
44.
45.
Dallago CM Abech DD Pereira-Lima JF Leães CG Batista RL Trarbach EB Oliveira Mda C 《Pituitary》2008,11(1):109-112
Kallmann syndrome (KS) is a developmental disease characterized by the association of isolated hypogonadotropic hypogonadism
and anosmia/hyposmia. We report an unusual presentation of two females with KS and empty sella. These females, aged at 20
and 29-year-old, presented primary amenorrhea with prepubertal estradiol and low gonadotropin levels. No other significant
clinical signs were observed. Empty sella was observed on MRI in both cases. Sequencing of FGFR1 gene, recently implicated in autosomal form of KS, was performed and one splicing mutation (IVS14 + 1G > A) was identified
in one patient. 相似文献
46.
Saidy Vásconez Noguera Evelyn Patrícia Sánchez Espinoza Marina Farrel Côrtes Izabel Cristina Vilela Oshiro Fernanda de Sousa Spadão Laura Maria Brasileiro Brandão Ana Natiele da Silva Barros Sibeli Costa Bianca Leal de Almeida Paula Gemignani Soriano Alessandra Grassi Salles Mirian Elizabete Marques Escorcio Cristina Madeira Barretti Fernanda Spadotto Baptista Glaura Souza Alvarenga Igor Marinho Leila Suemi Harima Letaif Ho Ye Li Silvia Figueiredo Costa 《American journal of infection control》2021,49(4):512-515
47.
Luduvico Karina Pereira Spohr Luiza de Aguiar Mayara Sandrielly Soares Teixeira Fernanda Cardoso Bona Natália Pontes de Mello Julia Eisenhardt Spanevello Roselia Maria Stefanello Francieli Moro 《Metabolic brain disease》2022,37(6):2133-2140
Metabolic Brain Disease - Acetylcholine is an excitatory neurotransmitter that modulates synaptic plasticity and communication, and it is essential for learning and memory processes. This... 相似文献
48.
Purpose of Review
To review and discuss the epidemiology, risk factors, clinical presentation, diagnosis, and treatment of non-tuberculous mycobacteria (NTM) in thoracic transplantation.Recent Findings
Non-tuberculous mycobacteria are ubiquitous but are an uncommon cause of disease after solid organ transplantation. The incidence of infection is higher in thoracic transplant recipients than in abdominal transplant recipients, with most cases seen after lung transplantation. It is associated with increased morbidity and, occasionally, mortality. Infection in the pre-transplant setting can occur in lung transplant candidates, often posing a dilemma regarding transplant listing. Disease manifestations are diverse, and pulmonary disease is the most common. Diagnosis requires a high index of suspicion. Treatment requires a multiple-drug combination and is limited by drug-drug interactions and tolerability. Mycobacterium abscessus is a challenge in lung transplant recipients, due to its intrinsic resistance and propensity to relapse even after prolonged therapy. Mycobacterium chimaera is an emerging pathogen associated with contamination of heater-cooler units and is described to cause disease months after cardiothoracic surgery.Summary
NTM infections in thoracic organ transplant recipients are uncommon but are associated with substantial morbidity and mortality. Data from larger multicenter studies is needed to better define the epidemiology of NTM in thoracic transplantation, best treatment options, and the management of infected transplant candidates.49.
50.
Rodrigo Guimar?es dos Santos Almeida Alessandra Mazzo José Carlos Amado Martins Rui Carlos Negr?o Baptista Fernanda Berchelli Gir?o Isabel Amélia Costa Mendes 《Revista latino-americana de enfermagem》2015,23(6):1007-1013