全文获取类型
收费全文 | 720篇 |
免费 | 27篇 |
国内免费 | 77篇 |
专业分类
儿科学 | 31篇 |
妇产科学 | 62篇 |
基础医学 | 60篇 |
口腔科学 | 6篇 |
临床医学 | 97篇 |
内科学 | 155篇 |
皮肤病学 | 15篇 |
神经病学 | 64篇 |
特种医学 | 96篇 |
外科学 | 43篇 |
综合类 | 24篇 |
预防医学 | 9篇 |
眼科学 | 5篇 |
药学 | 62篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 93篇 |
出版年
2023年 | 5篇 |
2022年 | 13篇 |
2021年 | 9篇 |
2020年 | 5篇 |
2019年 | 6篇 |
2018年 | 10篇 |
2017年 | 5篇 |
2016年 | 13篇 |
2015年 | 19篇 |
2014年 | 21篇 |
2013年 | 26篇 |
2012年 | 29篇 |
2011年 | 30篇 |
2010年 | 17篇 |
2009年 | 22篇 |
2008年 | 11篇 |
2007年 | 67篇 |
2006年 | 27篇 |
2005年 | 36篇 |
2004年 | 26篇 |
2003年 | 13篇 |
2002年 | 12篇 |
2001年 | 18篇 |
2000年 | 22篇 |
1999年 | 15篇 |
1998年 | 24篇 |
1997年 | 34篇 |
1996年 | 26篇 |
1995年 | 23篇 |
1994年 | 19篇 |
1993年 | 15篇 |
1992年 | 6篇 |
1991年 | 10篇 |
1990年 | 11篇 |
1989年 | 19篇 |
1988年 | 19篇 |
1987年 | 11篇 |
1986年 | 14篇 |
1985年 | 15篇 |
1984年 | 7篇 |
1983年 | 6篇 |
1982年 | 14篇 |
1981年 | 15篇 |
1980年 | 10篇 |
1979年 | 5篇 |
1978年 | 8篇 |
1977年 | 7篇 |
1976年 | 10篇 |
1975年 | 10篇 |
1971年 | 2篇 |
排序方式: 共有824条查询结果,搜索用时 15 毫秒
1.
2.
3.
Kundel HL; Gefter W; Aronchick J; Miller W Jr; Hatabu H; Whitfill CH; Miller W Sr 《Radiology》1997,205(3):859
4.
U. Bickel J. Born H. L. Fehm M. Distler K. H. Voigt 《European journal of clinical pharmacology》1988,35(4):371-377
Summary A specific radioimmunoassay for the quantitative measurement of ACTH 4-10 and a procedure for its extraction from plasma have been developed.Its pharmacokinetics was studied in eight healthy male volunteers given ACTH 4-10 125 µg/kg body weight as a bolus i.v. injection, by infusion and intranasally. Following the i.v. bolus, plasma levels rapidly declined biexponentially, with half-lives of 0.39±0.05 min for the -phase and 3.84 ± 1.5 min for the -phase (mean±SD). The constant rate i.v. infusion yielded steady-state levels between 0.74 and 5.06 ng/ml plasma. Administered as intranasal spray, absorption of intact ACTH 4-10 was low and variable (maximal bioavailability 7.6%).The results are discussed in relation to the dose-dependent effects of ACTH 4-10 on the auditory evoked potential. 相似文献
5.
Molecular genetic characterization of XRCC4 function 总被引:2,自引:0,他引:2
XRCC4 is a generally expressed protein of 334 amino acids that is involved
in the repair of DNA double-strand breaks and in V(D)J recombination, but
its function is unknown. In this study, we have used a mutational approach
and the yeast two-hybrid method to perform an initial characterization of
this protein. We show that the XRCC4 protein is located in the nucleus. We
also demonstrate that several potential phosphorylation sites are not
required for XRCC4 function in a transient V(D)J recombination assay. In
addition, we show that XRCC4 forms a homodimer in vivo with the
homodimerization domain being located within amino acids 115-204. Finally,
we define a core domain of XRCC4 that functions in V(D)J recombination and
comprises amino acids 18-204. Potential functions of XRCC4 are discussed.
相似文献
6.
Rudolf Ernst Lang Karl-Heinz Voigt Horst Lorenz Fehm Ernst Friedrich Pfeiffer 《Neuroscience letters》1976,2(1):19-22
Hypothalamic nuclei were removed from frozen sections of rat brain and examined for their corticotropin-releasing activity. The highest concentration was measured in the median eminence. In addition there was significantly more activity detected in the nuclei paraventricularis, supraopticus, suprachiasmaticus and arcuatus than in the other nuclei. 相似文献
7.
8.
Central nervous system effects of intranasally administered insulin during euglycemia in men 总被引:5,自引:0,他引:5
Insulin receptors have been detected in several structures of the brain, yet the biological significance of insulin acting on the brain remains rather unclear. In humans, direct central nervous effects of insulin are difficult to distinguish from alterations in neuronal functions because of insulin-induced decrease in blood glucose levels. Since several intranasally administered viruses, peptides, and hormones have been shown to penetrate directly from the nose to the brain, we tested whether insulin after intranasal administration likewise has access to the brain. After a 60-min baseline period, insulin (20 IU H-Insulin 100 Hoechst) or vehicle (2.7 mg/ml m-Cresol) was intranasally administered every 15 min to 18 healthy subjects according to a double-blind within-subject crossover design. Auditory-evoked potentials (AEP) indexing cortical sensory processing were recorded while the subjects performed a vigilance task (oddball paradigm) during the baseline phase and after 60 min of intranasal treatment with insulin or placebo. Blood glucose and serum insulin levels were not affected by intranasal insulin. Compared with placebo, intranasal administration of insulin reduced amplitudes of the N1 (P < 0.005) and P3 (P < 0.02) components of the AEP and increased P3 latency (P < 0.05). The reduction in P3 amplitude was most pronounced over the frontal recording site (2.42 +/- 1.00 vs. 4.92 +/- 0.79 microV, P < 0.0005). At this site, after insulin administration, a broad negative shift developed in the AEP between 280 and 500 ms poststimulus (area under the curve -166.0 +/- 183.8 vs. 270.8 +/- 138.7 microV x ms after placebo, P < 0.01). The results suggest that after intranasal administration, insulin directly enters the brain and exerts distinct influences on central nervous functions in humans. 相似文献
9.
Svjetlana Mohrmann Anna Maier-Bode Frederic Dietzel Petra Reinecke Natalia Krawczyk Thomas Kaleta Ulrike Kreimer Gerald Antoch Tanja N. Fehm Katrin Sabine Roth 《Breast care (Basel, Switzerland)》2022,17(2):159
BackgroundThe question of how to deal with B3 lesions is of emerging interest.MethodsIn the breast diagnostics of 192 patients between 2009 and 2016, a minimally invasive biopsy revealed a B3 lesion with subsequent resection. This study investigates the malignancy rate of different B3 subgroups and the risk factors that play a role in obtaining a malignant finding.ResultsThe distribution of B3 lesions after minimally invasive biopsy was as follows: atypical ductal hyperplasia (ADH), 7.3%; flat epithelial atypia (FEA), 7.8%; lobular neoplasia (LN), 7.8%; papilloma (Pa), 49.5%; phylloidal tumour (PT), 8.9%; radial sclerosing scar (RS), 3.1%; mixed findings, 10.4%; and other B3 lesions, 5.2%. Most B3 lesions were detected by stereotactic vacuum-assisted biopsy (44.3%), 36.5% by ultrasound-assisted biopsy, and 19.3% by magnetic resonance imaging-assisted biopsy. Most B3 lesions (55.2%) were verified by surgical resection, whereas 30.7% were downgraded to a benign lesion. About 14.1% of the cases were upgraded to malignant lesions, 9.4% to ductal carcinoma in situ and 4.7% to invasive carcinoma. In relation to individual B3 lesions, the following malignancy rates were found: 28.6% (ADH), 13.3% (FEA), 33.3% (LN), 12.6% (Pa), 5.9% (PT), and 0% (RS). The most important risk factor was increasing age. Postmenopausal status was considered an increased risk for an upgrade (p = 0.015). A known malignancy in the ipsilateral breast was a significant risk factor for a malignant upgrade (p = 0.003).ConclusionIncreasing knowledge about B3 lesions allows us to develop a “lesion-specific” therapy approach in the heterogeneous group of B3 lesions, with follow-up imaging for some lesions with less malignant potential and concordance with imaging or further surgical resection in cases of disconcordance with imaging or higher malignant potential. 相似文献
10.
Volkmar Müller Sabine Riethdorf Brigitte Rack Wolfgang Janni Peter A Fasching Erich Solomayer Bahriye Aktas Sabine Kasimir-Bauer Klaus Pantel Tanja Fehm 《Breast cancer research : BCR》2012,14(4):1-8