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排序方式: 共有1047条查询结果,搜索用时 15 毫秒
91.
92.
Ahmad Nazrun Shuid Sharlina Mohamad Norazlina Mohamed Fazalina Mohd Fadzilah Sabarul Afian Mokhtar Shahrum Abdullah Faizah Othman Farihah Suhaimi Norliza Muhammad Ima Nirwana Soelaiman 《Journal of orthopaedic research》2010,28(12):1651-1656
Fracture healing is a complex process, which is further complicated if the bone is osteoporotic. Calcium is one of the important minerals in bone and has been found to prevent osteoporosis but its role in fracture healing of osteoporotic bone is still unclear. We carried out a study on the effects of calcium supplementation on the late phase healing of fractured osteoporotic bone using an ovariectomized rat model. Twenty‐four female Sprague–Dawley rats were divided into three groups: sham‐operated (SO), ovariectomized‐control (OVXC), and ovariectomized + calcium supplements (Ca). The right femurs of all the rats were fractured at mid‐epiphysis and a K‐wire was inserted for internal fixation. After 2 months of treatment, the rats were sacrificed and the femora were dissected out for radiological and biomechanical assessment. As expected, osteoporosis resulted in impaired healing as shown by the poor radiological and biomechanical properties of the OVXC group. CT scans showed significantly lower callus volumes in the SO and Ca groups compared to the OVXC group. Radiological scoring of fracture healing and callus staging of the SO and Ca groups were better than the OVXC group. However, the biomechanical parameters of the Ca group were significantly lower than the SO group and similar to the OVXC group. Therefore, calcium supplements may appear to improve fracture healing of osteoporotic bone but failed to improve strength. © 2010 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 28:1651–1656, 2010 相似文献
93.
94.
A. Y. Othman 《European journal of orthopaedic surgery & traumatology : orthopedie traumatologie》2004,14(4):225-229
The aim of the study was to examine the clinical outcome of fixing unstable intertrochanteric fractures using a newly designed 102° dynamic condylar screw (DCS). Twelve unstable low-energy intertrochanteric fractures were fixed using 102° DCS. Patient ages ranged from 79 to 92 years. The follow-up period was from 6 to 15 months. Patients were assessed clinically and radiographically. Fracture healing was achieved in 11 patients within the follow-up period. Implant failure was seen in one patient, as the screw cut out of the femoral head. In conclusion, the 102° DCS showed promising results when used for fixing unstable intertrochanteric fractures. It is easier to apply in comparison to the 95° DCS, as it offers wider safety zone for insertion in the femoral neck, which allows a secure screw placement in the femoral head. Larger randomised comparative studies would be of value for further evaluation of the new device. 相似文献
95.
Torjman L Ladeb S Lakhal A Ben Othman T Abdelkefi A Ben Abdeladhim A 《La Tunisie médicale》2007,85(1):35-38
AIM: In the present study we report the clinical outcome of 27 patients with refractory or relapsed Hodgkin's lymphoma (HL) undergoing autologous peripheral stem-cell transplantation (ASCT). METHODS: On transplant, 18 patients had sensitive disease (SD) and 9 resistant disease (RD). The median time between diagnosis and ASCT was 18 months (range, 7 to 96 months). The conditioning consisted of BEAM regimen. RESULTS: The 100-day mortality rate was 3%. Three months after transplant, 12 patients transplanted with SD were in complete remission (CR) and only one of the 9 patients transplanted with RD achieved CR. Overall survival and disease-free survival after 3 years were 68% and 60%, respectively. CONCLUSION: the present results confirm the efficacy and safety of the ASCT in refractory or relapsed HL patients with SD. Other strategies should be investigated for patients with RD. 相似文献
96.
Bin Alamer Othman Haider Ali S. Haider Maryam Sagoo Navraj S. Robertson Faith C. Arrey Eliel N. Aoun Salah G. Yu Kenny Cohen-Gadol Aaron A. El Ahmadieh Tarek Y. 《Journal of neuro-oncology》2021,153(2):183-202
Journal of Neuro-Oncology - We aim to systematically review and summarize the demographics, clinical features, management strategies, and clinical outcomes of primary and radiation-induced... 相似文献
97.
Faheem Ullah Fatima Javed M. B. H. Othman Abbas Khan Rukhsana Gul Zulkifli Ahmad 《Journal of biomaterials science. Polymer edition》2018,29(4):376-396
Addressing the functional biomaterials as next-generation therapeutics, chitosan and alginic acid were copolymerized in the form of chemically crosslinked interpenetrating networks (IPNs). The native hydrogel was functionalized via carbodiimide (EDC), catalyzed coupling of soft ligand (1,2-Ethylenediamine) and hard ligand (4-aminophenol) to replace –OH groups in alginic acid units for extended hydrogel- interfaces with the aqueous and sparingly soluble drug solutions. The chemical structure, Lower solution critical temperature (LCST ≈ 37.88 °C), particle size (Zh,app ≈ 150–200 nm), grain size (160–360 nm), surface roughness (85–250 nm), conductivity (37–74 mv) and zeta potential (16–32 mv) of native and functionalized hydrogel were investigated by using FT-IR, solid state-13C-NMR, TGA, DSC, FESEM, AFM and dynamic light scattering (DLS) measurements. The effective swelling, drug loading (47–78%) and drug release (53–86%) profiles were adjusted based on selective functionalization of hydrophobic IPNs due to electrostatic complexation and extended interactions of hydrophilic ligands with the aqueous and drug solutions. Drug release from the hydrogel matrices with diffusion coefficient n ≈ 0.7 was established by Non- Fickian diffusion mechanism. In vitro degradation trials of the hydrogel with a 20% loss of wet mass in simulated gastric fluid (SGF) and 38% loss of wet mass in simulated intestinal fluid (SIF), were investigated for 400 h through bulk erosion. Consequently, a slower rate of drug loading and release was observed for native hydrogel, due to stronger H-bonding, interlocking and entanglement within the IPNs, which was finely tuned and extended by the induced hydrophilic and functional ligands. In the light of induced hydrophilicity, such functional hydrogel could be highly attractive for extended release of sparingly soluble drugs. 相似文献
98.
Sheila Lomongo Khalid Alyousef Reetta Mustonen Khalid Othman 《Journal of Radiology Nursing》2017,36(3):184-187
In 2015, an outbreak of Middle East respiratory syndrome coronavirus occurred in Saudi Arabia and necessitated special measures to be implemented to control the spread of the virus. In this article, we will discuss how the outbreak was managed in the vascular and interventional radiology (VIR) suite in a large tertiary care hospital in Saudi Arabia. Various measures were taken to reduce the risk of transmission of infection. Unit-level education played an important role in the care of patients. A hospital-wide educational program was implemented to ensure zero transmission of infection. Special attention was made to monitor staff who acquired the virus. VIR suite was able to handle the situation and control the outbreak. 相似文献
99.
The clinical spectrum of postpartum thyroid disease 总被引:1,自引:0,他引:1
Lazarus JH; Hall R; Othman S; Parkes AB; Richards CJ; McCulloch B; Harris B 《QJM : monthly journal of the Association of Physicians》1996,89(6):429-435
The clinical and biochemical features of postpartum thyroid disease were
analysed in 152 antithyroid peroxidase antibody-positive (anti TPO+ve)
women and compared with 239 anti-TPO-ve age-matched control postpartum
women. All were assessed monthly for up to 12 months postpartum. Seventy
three anti-TPO+ve women developed post-partum thyroiditis (PPT): 19.2%
hyperthyroid alone, 49.3% hypothyroid alone, and 31.5% characterized by
hyper- followed by hypothyroidism. None of the antibody-negative women
developed any thyroid dysfunction. A significant increase in many of eleven
symptoms of hypothyroidism and some of eight symptoms of hyperthyroidism
compared to control women was observed in all anti-TPO+ve women,
independent of thyroid status. This was particularly seen in women who
later developed PPT when they were euthyroid, but was also observed in
euthyroid anti-TPO+ve women who showed no decline of thyroid function
during the postpartum period. Although PPT is usually transient, this
condition, and the euthyroid antibody-positive state, may be associated
with significant symptomatology, including an increased incidence of minor
to moderate depression. Early recognition of this syndrome by antenatal
screening of thyroid antibodies may contribute to improved management of
women during the postpartum period.
相似文献
100.
Azza A Eltayeb Madleen Adel A Abdou Amal M Abdel-aal Mostafa H Othman 《World journal of gastroenterology : WJG》2015,21(4):1284-1291
AIM: To study the frequency of vitamin D deficiency in patients with hepatitis C virus(HCV) infection and to evaluate the role of vitamin D supplementation in improving antiviral therapy.METHODS: Sixty-six children aged from 7-14 years(mean ± SD, 11.17 ± 2.293) diagnosed with HCV infection were matched to 28 healthy controls. Serum levels of 25(OH) D3, calcium, phosphorus, alkaline phosphatase and plasma level of parathormone were measured. Quantitative PCR for HCV was performed Bone density was determined by dual energy X-ray absorptiometry. All cases received conventional therapy, and only 33 patients received vitamin D supplementation.RESULTS: Children with HCV showed significantly increased levels of HCV RNA(P 0.001), parathormone(P 0.01) and decreased vitamin D levels(P 0.05)(33.3% deficient and 43.3% insufficient) compared with controls. Abnormal bone status(Z score-1.98 ± 0.75) was found in ribs, L-spine, pelvis and total body. Cases treated with vitamin D showed significant higher early(P 0.04) and sustained(P 0.05) virological response. There was a high frequency of vitamin D deficiency among the Egyptian HCV children, with significant decrease in bone density. The vitamin D level should be assessed before the start of antiviral treatment with the correction of any detected deficiency. CONCLUSION: Adding vitamin D to conventional Peg/RBV therapy significantly improved the virological response and helped to prevent the risk of emerging bone fragility. 相似文献