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91.
目的:了解德清农村社区成人居民血小板减少情况及可能影响因素。方法:采用流行病学现况研究设计,整群抽取浙江省德清县4个农村社区,面对面调查上述社区中所有18周~64周岁的社区户籍居民。血小板减少定义为<100×109/L。在Epidata3.1中文版建立数据库,SPSS11.0中进行数据分析。结果:在4479名调查对象中,血小板减少粗患病率为21.2%;按照2000年全国人口进行年龄性别标化的患病率为18.6%,患病率随着年龄的增加而增加(χ2趋势=14.43,P<0.001)。在非条件logistic回归分析中,年龄较大、女性、吸烟、家庭年人均收入中低水平可能增加血小板减少的风险,而BMI与之负相关。结论:农村社区成人居民血小板减少患病率较高,应加强监控。 相似文献
92.
Mohammed Abutaqa Christelle Tayeh Fatme Charafeddine Fadi Bitar Mariam Arabi 《Echocardiography (Mount Kisco, N.Y.)》2019,36(5):1014-1016
Congenital diaphragmatic hernia (CDH) is a rare type of developmental defect of the diaphragm, occurring in 1 per 2000 pregnancies. Morgagni hernia, in particular, which results from an anterior defect of the diaphragm, is the least common type of CDH (5%). Herniation of the liver into the pericardial space, presenting as a thoracic mass with pericardial effusion, is an extremely rare form of Morgagni hernia. Such reported cases are few and occurred only in singleton pregnancies. To the best of our knowledge, we report the first case of fetal echocardiography and fetal MRI following referral due to large pericardial effusion. 相似文献
93.
Functional assembly and purinergic activation of bestrophins 总被引:1,自引:0,他引:1
Vladimir M. Milenkovic René Barro Soria Fadi Aldehni Rainer Schreiber Karl Kunzelmann 《Pflügers Archiv : European journal of physiology》2009,458(2):431-441
Proteins of the bestrophin family produce Ca2+-activated Cl− currents and regulate voltage-gated Ca2+ channels. Bestrophin 1 was first identified in the retinal pigment epithelium. Four human paralogs (hBest1–hBest4) exist,
and for some bestrophins, dimeric and heterotetrameric structures have been proposed. Here, we demonstrate that hBest1–hBest4
induce Cl− conductances of different amplitudes when expressed in HEK293 cells and when activated through purinergic stimulation. hBest1
mutants that are known to cause autosomal dominant macular dystrophy (Best disease) did not produce a Cl− current. Bestrophins were colocalized and showed molecular and functional interaction in HEK293 cells, overexpressing hBest1
and hBest2 or hBest4. Interaction was confirmed in airway epithelial cells coexpressing endogenous bestrophins. A fraction
of hBest2 and hBest4 was expressed in the membrane, while most of hBest1 was found in the endoplasmic reticulum. Nevertheless,
hBest1 has a clear role for the adenosine triphosphate (ATP; or uridine triphosphate)-induced Cl− current in both HEK293 and Calu-3 cells. Since native epithelial tissues typically express several bestrophin paralogs, these
proteins may exist as heterooligomeric structures.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
94.
Singer E Pilpel S Bsat F Plevyak M Healy A Markenson G 《Obstetrics and gynecology》2007,109(5):1083-1087
OBJECTIVE: To investigate accuracy of fetal fibronectin testing to predict preterm birth in twin gestations with symptoms of preterm labor. METHODS: We reviewed charts of all patients with twin gestations who underwent fetal fibronectin testing and presented with complaints of preterm labor between January 1, 2000, and June 30, 2004. We also reviewed the charts of all singleton gestations with similar complaints that had fetal fibronectin testing between January 1, 2000, and December 31, 2001. All samples were processed using a rapid fetal fibronectin detection system. We calculated the sensitivity, specificity, positive predictive value, and negative predictive value of fetal fibronectin testing in singleton and twin gestations in predicting delivery within 14 days of testing. RESULTS: Four hundred twenty-nine singletons and 87 twins met the inclusion criteria. The birth rate before 34 weeks of gestation for singletons was 3.5% compared with the rate of twin pregnancies of 28.7%. Fetal fibronectin predicted delivery within 14 days of testing with a sensitivity, specificity, and positive and negative predictive values in singleton gestations of 82%, 90%, 17%, and 99%, respectively. In twin gestations, fetal fibronectin predicted delivery within 14 days of testing with a sensitivity, specificity, and positive and negative predictive values of 71%, 74%, 19%, and 97%, respectively. CONCLUSION: As noted in singleton pregnancies, fetal fibronectin testing in twins has a high negative predictive value. Fetal fibronectin evaluation may be a useful tool in screening twins with symptoms of preterm labor, because a negative result places these women at a low risk for delivering within 2 weeks of testing. 相似文献
95.
96.
Olivier Jean-Franois Le Nhien Lin Chen-Hsuan Prieto Ignatio Basile Fadi Hemmerling Thomas 《Journal canadien d'anesthésie》2005,52(1):A79-A79
Canadian Journal of Anesthesia/Journal canadien d'anesthésie - 相似文献
97.
Michèle German-Fattal Florence Lecerf Fadi Sabbagh Pierre Maurois Jean Durlach Pierre Bac 《Biomedicine & Pharmacotherapy》2008,62(4):264-272
BACKGROUND: Magnesium (Mg) deficiency may lead to serious metabolic, biological and organic dysfunctions, and cause various clinical disorders. In the current study, we explore endothelial cell activation, inflammation and cell death induced in the brain of adult mice by Mg-deficient diet. METHODS AND RESULTS: Neither TNFalpha, substance P, sTNFRI, sTNFRII proteins (ELISA), nor TNFalpha, adherence molecules and prolactin mRNAs, nor NK1R (immunohistochemistry on brain sections) were up-regulated. No inflammatory infiltrates and no apoptotic cells were observed. Using cDNA assay, we showed a neuroprotective, anti-apoptotic and neurotrophic gene expression profile in the brain at early stage of hypomagnesemia. As a model for neuronal injury, mild sound stimulation of Mg-deficient mice without convulsive seizures triggers neither the release of substance P, nor the development of an inflammatory process or cell death in the brain. CONCLUSION: Our results suggest that Mg-deficiency in mice favours the development of a neuroprotective environment in the brain. 相似文献
98.
99.
Fadi Brimo MD Andrew A. Renshaw MD Majorie Deschenes MD Michele Charbonneau CT Manon Auger MD 《Cancer cytopathology》2009,117(5):311-317
BACKGROUND:
Documenting the performance of gynecologic screening in actual practice settings is difficult to achieve. In the current study, the screening performance of 11 individual cytotechnologists as well as that of the overall laboratory over 2 consecutive time periods was examined using the rapid prescreening (RPS) method.METHODS:
RPS was performed by all cytotechnologists in a single laboratory over 2 separate 8‐month periods. The sensitivity of screening for individual and groups of cytotechnologists was examined. For purposes of comparison, cytotechnologists were divided into 2 groups: screeners with an overall routine sensitivity ≥95% and screeners with an overall sensitivity <95%.RESULTS:
Atypical squamous cells (ASC) were used as a threshold, and routine screening sensitivity was found to vary from 68.3% to 96.8%. The overall sensitivity of the laboratory for RPS and routine screening was 43.6% and 88.4%, respectively. Over time, the overall laboratory sensitivity of routine screening improved from 85.3% to 91.3% (P = .01). During this same time frame, the sensitivity of the screeners with an overall sensitivity <95% improved from 79.3% to 91.2% (P < .001), whereas the sensitivity of screeners with an overall routine sensitivity ≥95% remained the same (96.1% to 96.4%; P = .6).CONCLUSIONS:
In addition to improved overall performance of the laboratory by detecting and correcting errors, the results of the current study indicate that using RPS consistently over time might play a role leading to improved performance of cytotechnologists with an overall routine sensitivity <95% but not of cytotechnologists with an overall routine sensitivity ≥95%. Cancer (Cancer Cytopathol) 2009. © 2009 American Cancer Society. 相似文献100.