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排序方式: 共有1711条查询结果,搜索用时 31 毫秒
71.
Thoracic spinal intradural arachnoid cyst: report of two cases and review of literature 总被引:1,自引:0,他引:1
We report two cases of spinal intradural arachnoid cyst at the thoracic level, presenting with long-standing symptoms of spinal cord compression and MRI findings that were overlooked for sometime initially. Because of the rarity of this disease, and because of the subtle changes on MRI, there was a definite delay in the diagnosis. In this report we emphasize the value of MRI and CT myelography in this disorder, and the need for them to be strongly correlated with the progression of the clinical picture. 相似文献
72.
Afshin Dowlati Kelly Robertson Tomas Radivoyevitch John Waas Nicholas P Ziats Paul Hartman Fadi W Abdul-Karim Jay K Wasman Jack Jesberger Jonathan Lewin Keith McCrae Percy Ivy Scot C Remick 《Clinical cancer research》2005,11(21):7938-7944
PURPOSE: To determine the biological modulatory dose of SU5416, we employed a novel trial design, where "dose de-escalation" was based on demonstrable biological changes observed at the maximum tolerated dose. If such an effect was shown, dose de-escalation to a predefined dose level would occur to determine if the lower dose exhibited the same amount of pharmacodynamic effect as the higher dose. EXPERIMENTAL DESIGN: Ten patients with advanced solid tumors were enrolled at each dose level. One of the following pharmacodynamic effects was considered significant: (a) a 35% decrease in microvessel density in sequential tumor biopsies and (b) a 35% decrease in blood flow within tumor as assessed by dynamic contrast-enhanced magnetic resonance imaging. In addition, soluble E-selectin, soluble intercellular adhesion molecule, soluble vascular cell adhesion molecule, and plasma vascular endothelial growth factor were measured sequentially. RESULTS: Nineteen patients were enrolled. Sequential tumor biopsies in all evaluable patients showed an increase in microvessel density. Only one patient met the intended pharmacodynamic end point of >35% reduction in blood flow. There was a significant increase in both soluble E-selectin and soluble intercellular adhesion molecule levels pretreatment versus levels at the time of removal of patients from study (P = 0.04 and P = 0.0007, respectively). Levels of serum fibrinogen rose with therapy. There was a trend toward increase in plasma vascular endothelial growth factor levels. CONCLUSION: SU5416 does not result in decreased blood flow in tumors or a decrease in microvessel density. This corresponds to the lack of clinical activity seen with this agent. Our clinical trial design termed dose de-escalation is a novel approach to determine the in vivo biological effects of targeted therapies in cancer patients. 相似文献
73.
74.
Ghanem I Khalife R Haddad F Kharrat K Dagher F 《Journal of pediatric orthopedics. Part B》2005,14(6):422-425
The objective of this study was to assess the course, the epidemiologic features and the prognosis of recurrent Legg-Calvé-Perthes disease. We reviewed seven reported cases and one personal case of recurrent Perthes' disease. In all cases, complete recovery from the previous episode was documented, and a thorough diagnostic work-up to rule out other diseases was undertaken. There were five boys. Age at onset ranged from 2 to 6 years. Five patients had bilateral involvement. Recurrence took place 1-5 years after complete healing of the initial one. Clinical and radiological pictures were similar to those found in primary Perthes' disease of the adolescent and consisted in a greater epiphyseal involvement. Recurrent Perthes' disease is very rare. We did not identify any risk factors for recurrence. A worse outcome is more closely related to an older age of the patient at recurrence than to recurrence itself. 相似文献
75.
This paper presents a spectral autoregressive method dedicated to the detection of ultrasound contrast agents (USCA) from radiofrequency (rf) data. The method is based on second-order autoregressive (AR) modeling of the rf signal. Contrast agents induce a second harmonic, which may be efficiently detected through the AR spectrum using the magnitude of the second AR spectral peak (SM2). In contrast to multipulse methods that process two or more rf frames, our method processes a single rf frame. The method is tested by numerical simulation and on in vitro data for contrast agent concentrations ranging from 10(3) to 50 x 10(3) bubbles/ml (2 x 10(-6) to 10(-4) volumic concentration) and mechanical index (MI) ranging from 0.1 to 0.36. The results show that the proposed parameter SM2 enables one to detect correctly the contrast agent, in particular at low concentration and MI (the minimum difference in SM2 between tissue and USCA is 10 dB). Furthermore, the in-vitro data demonstrates that an adapted smoothing technique reduces the variability of SM2 and provides accurate and stable segmentation of the contrast agent perfusion region. 相似文献
76.
77.
This article highlights new developments in assessment and management of pain and delirium. 相似文献
78.
Long-term effects of acute and of chronic hypoxia on behavior and on hippocampal histology in the developing brain 总被引:2,自引:0,他引:2
Mikati MA Zeinieh MP Kurdi RM Harb SA El Hokayem JA Daderian RH Shamseddine A Obeid M Bitar FF El Sabban M 《Brain research. Developmental brain research》2005,157(1):98-102
Ten-day-old rat pups (P10) subjected to acute hypoxia (down to 4% O2) had as adults increased aggression (handling test), memory impairment (water maze test), and decreased CA1 cell counts. Pups subjected to chronic hypoxia (10% O2 from P0 to P21) had increased aggression, hyperactivity (open-field test), and decreased CA1 cell counts. Chronic hypoxia with superimposed acute hypoxia resulted in consequences that were not different from those of chronic hypoxia. 相似文献
79.
Zeitani J Bertoldo F Bassano C Penta de Peppo A Pellegrino A El Fakhri FM Chiariello L 《The Annals of thoracic surgery》2004,77(2):672-675
BACKGROUND: Superficial wound dehiscence after midline sternotomy is considered a minor complication in cardiac surgery, although it is quite frequent and requires prolonged medical treatment. It can be managed conventionally by topical treatment, with delayed secondary healing, or by surgical treatment and primary skin closure. We report the outcome of 96 patients who underwent conventional treatment, compared with a second group of 42 patients who underwent surgical treatment and direct closure. METHODS: From October 1999 to December 2002, 2400 consecutive patients underwent median sternotomy: 207 patients had sternal wound complications: 3 patients (0.125%) had mediastinitis, 66 patients (2.75%) had aseptic deep sternal wound dehiscence, and 138 patients (5.75%) had superficial wound dehiscence. The latter are the object of the present study; patients entered a protocol of skin wound care on an outpatient basis. The first 96 consecutive patients (group 1) required medications three times a week until complete healing. The last 42 patients (group 2) were treated by extensive surgical debridement of skin and subcutaneous tissue, direct closure of the superficial layers, and suture removal after 15 days. RESULTS: The two groups were comparable as to age, sex, and preoperative risk factors. The incidence of contaminated wounds was similar in the two groups (32 of 96 in group 1 and 11 of 42 in group 2; p = NS). The length of treatment was 29.7 days (range 2 to 144 days) for group 1 and 12.2 days (range 2 to 37 days) for group 2 (p < 0.0001). The mean number of medical treatments was 9.4 per patient in group 1 and 3.7 per patient in group 2 (p < 0.0001). CONCLUSIONS: Surgical debridement and primary closure of superficial surgical wound dehiscence after median sternotomy is a safe and valid treatment. Wound infection is not a contraindication to surgical treatment. Primary closure may contribute to reduce the risk for later infection. It also definitely contributes to decreasing healing time and strongly lessens patients' discomfort, diminishing hospital costs and hospital staff workload. 相似文献
80.
OCT4: a novel biomarker for dysgerminoma of the ovary 总被引:7,自引:0,他引:7