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Salwa Sebti Christine Prébois Esther Pérez-Gracia Chantal Bauvy Fabienne Desmots Nelly Pirot Céline Gongora Anne-Sophie Bach Andrew V. Hubberstey Valérie Palissot Guy Berchem Patrice Codogno Laetitia K. Linares Emmanuelle Liaudet-Coopman Sophie Pattingre 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(11):4115-4120
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Campa D Martino A Sainz J Buda G Jamroziak K Weinhold N Vieira Reis RM García-Sanz R Jurado M Ríos R Szemraj-Rogucka Z Marques H Lesueur F Bugert P Moreno V Szemraj J Orciuolo E Gemignani F Rossi AM Dumontet C Petrini M Goldschmidt H Landi S Canzian F 《British journal of haematology》2012,157(3):331-338
Genome-wide association studies (GWAS) have shown that the 8q24 region harbours multiple independent cancer susceptibility loci, even though it is devoid of genes. Given that no GWAS data are currently available for multiple myeloma (MM), we tested the hypothesis that genetic variants in this region could play a role in MM risk. We genotyped 20 single nucleotide polymorphisms of 8q24 in 1188 MM cases and 2465 controls and found a statistically significant (P = 0·0022) association between rs2456449 and MM risk. These data provide further evidence that the genetic variability in the 8q24 region is associated with cancer risk, particularly haematological malignancies. 相似文献
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Stephane Besnard Hanan Khemiri Fabienne Masse Pierre Denise Marion Verdaguer Christian Gestreau 《Sleep & breathing》2012,16(1):135-147
Background
Serotonin (5-HT) has a role in respiratory function and dysfunction. Although 5-HT affects respiratory drive to both phrenic and cranial motoneurons, relatively little is known about the role of 5-HT receptor subtypes in the control of upper airway muscle (UAM) respiratory activity. 相似文献59.
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Annette Lennerling Charlotte Lovén Frank JMF Dor Frederike Ambagtsheer Nathalie Duerinckx Mihaela Frunza Assya Pascalev Willij Zuidema Willem Weimar Fabienne Dobbels 《Transplant international》2013,26(2):145-153
In Europe, living organ donation (LOD) is increasingly accepted as a valuable solution to overcome the organ shortage. However, considerable differences exist between European countries regarding frequency, practices and acceptance of donor–recipient relations. As a response, the Coordination Action project ‘Living Organ Donation in Europe’ ( www.eulod.eu ), funded by the Seventh Framework Programme of the European Commission, was initiated. Transplant professionals from 331 European kidney and liver transplant centres were invited to complete an online survey on living kidney donation (LKD) and living liver donation (LLD). In total, 113 kidney transplant centres from 40 countries and 39 liver transplant centres from 24 countries responded. 96.5% and 71.8% performed LKD and LLD respectively. The content of the medical screening of donors was similar, but criteria for donor acceptance varied. Few absolute contraindications for donation existed. The reimbursement policies diverged and the majority of the donors did not get reimbursed for their income loss during recovery. Large discrepancies were found between geographical European regions (the Eastern, the Mediterranean and the North‐Western). As a result of this survey we suggest several recommendations to improve quality and safety of LOD in Europe. 相似文献