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41.
Müller Friedrich Martius Simon Fischer W. Rosenow Juliusberg Braun Schmitz Magnus-Alsleben Goldschmidt Fabian Friedberg Eckstein Fischer A. W. Weigert Oppenheimer Koenigsfeld Hayward Herzfeld Halberstädter Holthusen Dietrich Dietlen Peiper Dessecker Westenhöfer Flury Nick Schlesinger Tobias Loewy-Hattendorf Steiner Goldstein Naef Jahnel Henning Köllner Meesmann Preuss Igersheimer Esch Kobrak Sturmann Vogel 《Journal of molecular medicine (Berlin, Germany)》1922,1(20):1010-1021
Journal of Molecular Medicine - 相似文献
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Martius-Rostock Fischer Henning Lewin Rosenberg Oppenheimer Neisser Edens Deusch Dietlen Halberstaedter Griesbach Loewy Levinger Hellwig Zinn Simon Dessecker Schlesinger Fabian Schiff Göpppert Friedberg Freudenberg Esch Jonas Dietrich Tobler Juliusberg Engwer Igersheimer Gottstein Dresel Seligmann Gerbis 《Journal of molecular medicine (Berlin, Germany)》1922,1(3):138-145
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(1) Background: Mitochondria are the cells’ main source of energy. Mitochondrial dysfunction represents a key hallmark of aging and is linked to the development of Alzheimer’s disease (AD). Maintaining mitochondrial function might contribute to healthy aging and the prevention of AD. The Mediterranean diet, including walnuts, seems to prevent age-related neurodegeneration. Walnuts are a rich source of α-linolenic acid (ALA), an essential n3-fatty acid and the precursor for n3-long-chain polyunsaturated fatty acids (n3-PUFA), which might potentially improve mitochondrial function. (2) Methods: We tested whether a lipophilic walnut extract (WE) affects mitochondrial function and other parameters in human SH-SY5Y cells transfected with the neuronal amyloid precursor protein (APP695). Walnut lipids were extracted using a Soxhlet Extraction System and analyzed using GC/MS and HPLC/FD. Adenosine triphosphate (ATP) concentrations were quantified under basal conditions in cell culture, as well as after rotenone-induced stress. Neurite outgrowth was investigated, as well as membrane integrity, cellular reactive oxygen species, cellular peroxidase activity, and citrate synthase activity. Beta-amyloid (Aβ) was quantified using homogenous time-resolved fluorescence. (3) Results: The main constituents of WE are linoleic acid, oleic acid, α-linolenic acid, and γ- and δ-tocopherol. Basal ATP levels following rotenone treatment, as well as citrate synthase activity, were increased after WE treatment. WE significantly increased cellular reactive oxygen species but lowered peroxidase activity. Membrane integrity was not affected. Furthermore, WE treatment reduced Aβ1–40 and stimulated neurite growth. (4) Conclusions: WE might increase ATP production after induction of mitochondrial biogenesis. Decreased Aβ1–40 formation and enhanced ATP levels might enhance neurite growth, making WE a potential agent to enhance neuronal function and to prevent the development of AD. In this sense, WE could be a promising agent for the prevention of AD. 相似文献
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Franz Pfeiffer Julia Herzen Marian Willner Michael Chabior Sigrid Auweter Maximilian Reiser Fabian Bamberg 《Zeitschrift für medizinische Physik》2013,23(3):176-185
In this review article we describe the development of grating-based X-ray phase-contrast imaging, with particular emphasis on potential biomedical applications of the technology. We review the basics of image formation in grating-based phase-contrast and dark-field radiography and present some exemplary multimodal radiography results obtained with laboratory X-ray sources. Furthermore, we discuss the theoretical concepts to extend grating-based multimodal radiography to quantitative transmission, phase-contrast, and dark-field scattering computed tomography. 相似文献
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Right heart function in impaired left ventricular diastolic function: 2D speckle tracking echocardiography–based and Doppler tissue imaging–based analysis of right atrial and ventricular function
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Anna Brand MD Marny Bathe Sabine Oertelt‐Prigione MScPH Ute Seeland MD Mirjam Rücke MSc Vera Regitz‐Zagrosek MD Karl Stangl MD Fabian Knebel MD Verena Stangl MD Henryk Dreger MD 《Echocardiography (Mount Kisco, N.Y.)》2018,35(1):47-55
Aim
The aim of our study was to describe right atrial (RA) and right ventricular (RV) function, assessed by Doppler tissue imaging and 2D speckle tracking echocardiography (2DSTE), in women with signs of early impaired left ventricular diastolic function (DD).Methods and Results
In a cross‐sectional trial, standard parameters of diastolic and right heart function were investigated in 438 women of the Berlin Female Risk Evaluation (BEFRI) study. In a subset of women, average peak systolic RA strain (RAS), as well as the average peak systolic RV strain of the free wall (RVS free wall) and of all RV segments (average RV strain; RVS Avg), was analyzed using 2DSTE. Compared to women with normal diastolic function (DD0), RAS, RVS free wall and RVS Avg were significantly reduced in DD (43.1% ± 11.9%, ?26.7% ± 5.6%, and ?23.3% ± 3.5% in DD0; vs 35.1% ± 10.4%, ?23.9% ± 5.5%, and ?20.6% ± 3.8% in DD; P < .01). Peak RV myocardial velocity (RV‐IVV) and acceleration during isovolumetric contraction (RV‐IVA) were markedly higher in DD (15.0 ± 3.9 cm/s and 3.1 ± 1.0 m/s² in DD vs 11.9 ± 3.2 cm/s and 2.8 ± 0.8 m/s² in DD0; P < .05). RAS and RV‐IVV were significantly associated with DD after adjustment to age, BMI, and left atrial strain in multivariate regression analysis.Conclusion
Systolic right heart function is significantly altered in DD. DTI as well as 2DSTE constitute sensitive echocardiographic tools that enable the diagnosis of impaired right heart mechanics in early‐staged DD. 相似文献48.
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Is parental oral health literacy a predictor of children's oral health outcomes? Systematic review of the literature
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![点击此处可从《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ramon Targino Firmino Fernanda Morais Ferreira Carolina Castro Martins Ana Flávia Granville‐Garcia Fabian Calixto Fraiz Saul Martins Paiva 《International journal of paediatric dentistry / the British Paedodontic Society [and] the International Association of Dentistry for Children》2018,28(5):459-471
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