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TOSHIAKI IHARA MD KAICHI OITANI SADAYOSHI TORIGOE KENJI KITAMURA MASAHIRO ITO HITOSHI KAMIYA MINORU SAKURAI 《Pediatrics international》1994,36(1):53-56
To eliminate the role of natural killer (NK), antibody-dependent cell-mediated cytotoxicity (ADCC), and polymorphonuclear leukocyte (PMN)-mediated cytotoxicity in Varicella zoster virus (VZV) infections, peripheral blood mononuclear cell (PBMC)-mediated NK and ADCC, and phorbol myristate acetate-stimulated PMN-mediated cytotoxicity against VZV-infected targets were studied in children with leukemia. Natural killer and PMN-mediated cytotoxic activity was depressed for 6 months after complete remission and ADCC activity was depressed for 1 year after complete remission. The magnitude of three cytotoxic mechanisms in leukemic children gradually increased while they continued in complete remission. These results suggested that decreased cytotoxic activities of PBMC and PMN might contribute to serious VZV infections and susceptibility to herpes zoster in leukemic children. 相似文献
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Abstract Embryopathy in yellow KK mice with non-insulin dependent diabetes mellitus was examined among the conceptuses of females mated at 7, 11, and 13 weeks of age.
The numbers of corpora lutea and implants were comparable in all maternal age groups. Early embryonic deaths were frequently observed in all maternal age groups (37.7 46.4%), but no significant difference was found among the groups. The incidence of late embryonic deaths was significantly higher in 11- and 13-wk-old dams (25.6% and 28.8%) than in 7-wk-old dams (14.4%). Moreover, in 13-wk-old dams, but not in 7-wk-old dams, a positive correlation existed between maternal plasma glucose levels on day 18 of pregnancy and late embryonic deaths. Fetuses from 13-wk-old dams weighed less than those from 7-wk-old dams (0.73 g vs 0.86 g).
Yellow KK mice mated at 13 weeks of age were treated with an oral-hypoglycemic agent, 5-[4-(l-methylcyclohexylmethoxy)benzyl] thiazolidine-2,4-dione (ciglitazone), as an 0.1% dietary admixture. Plasma glucose on day 18 of pregnancy was lower in all treated groups (159-170 mg/dl) than in the untreated control (345 mg/dl). A significant decrease of late embryonic deaths (12.7-15.6%) and a slight increase of fetal weights (0.79-0.81 g) were noted when compared with the untreated controls (36.8% and 0.74 g). 相似文献
The numbers of corpora lutea and implants were comparable in all maternal age groups. Early embryonic deaths were frequently observed in all maternal age groups (37.7 46.4%), but no significant difference was found among the groups. The incidence of late embryonic deaths was significantly higher in 11- and 13-wk-old dams (25.6% and 28.8%) than in 7-wk-old dams (14.4%). Moreover, in 13-wk-old dams, but not in 7-wk-old dams, a positive correlation existed between maternal plasma glucose levels on day 18 of pregnancy and late embryonic deaths. Fetuses from 13-wk-old dams weighed less than those from 7-wk-old dams (0.73 g vs 0.86 g).
Yellow KK mice mated at 13 weeks of age were treated with an oral-hypoglycemic agent, 5-[4-(l-methylcyclohexylmethoxy)benzyl] thiazolidine-2,4-dione (ciglitazone), as an 0.1% dietary admixture. Plasma glucose on day 18 of pregnancy was lower in all treated groups (159-170 mg/dl) than in the untreated control (345 mg/dl). A significant decrease of late embryonic deaths (12.7-15.6%) and a slight increase of fetal weights (0.79-0.81 g) were noted when compared with the untreated controls (36.8% and 0.74 g). 相似文献
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