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61.
EMI NAKASHIMA RYO MATSUSHITA NAOMI KANADA FUJIO ICHIMURA 《The Journal of pharmacy and pharmacology》1996,48(4):347-350
To evaluate the dose dependency in apparent peritoneal permeability (Pd) of benzoic acid as a model compound for a monocarboxylic acid transport system, a kinetic model, which involves changes in the volume and osmolality of the dialysate as well as the diffusion and convection of drugs across the peritoneum, was applied. We compared the Pd value of benzoic acid to that of phenobarbital which is a more lipophilic drug than benzoic acid. The concentration-time courses of phenobarbital in both peritoneal cavity and serum after the intraperitoneal administration with various doses were parallel according to dose, whereas those of benzoic acid varied in a dose-dependent manner. Using the values of unbound fraction (fu), the value of Pd for unbound drugs was estimated. The Pd values of benzoic acid at 20 μg mL?1 was three times the value determined at 1000 μg mL?1. We suggest that certain facilitated transport systems constitute the mechanism of enhanced peritoneal membrane permeability of benzoic acid. 相似文献
62.
Motohide FURUYA Tsuyoshi MIYAOKA Hideaki YASUDA Satoko YAMASHITA Ippei TANAKA Shoko OTSUKA Rei WAKE Jun HORIGUCHI 《Psychogeriatrics》2012,12(4):259-262
Delirium is a common and serious acute neuropsychiatric syndrome characterized by inattention and global cognitive dysfunction. Delirium is associated with higher morbidity, higher mortality and longer hospitalization, but its aetiology remains unclear. We successfully treated five cases of delirium within 1 day with ramelteon, a novel selective melatonin receptor agonist. This suggests that correction of the circadian rhythm disturbance, one of the main symptoms of delirium, plays a crucial role in its treatment and sheds new light on a therapeutic strategy for treatment of delirium. 相似文献
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YASUHIRO KAWACHI M.D. SHIJIMA TAGUCHI M.D. YASUHIRO FUJISAWA M.D. JUNICHI FURUTA M.D. YASUHIRO NAKAMURA M.D. YOSHIYUKI ISHII M.D. FUJIO OTSUKA M.D. 《Pediatric dermatology》2011,28(2):205-207
Abstract: The linear arrangement of discoid lupus erythematosus is uncommon. Here, we report a 6‐year‐old Japanese girl with linear discoid lupus erythematosus following the lines of Blaschko on her face and neck. Topical tacrolimus treatment improved the eruptions. The present case also indicated the important role of epidermal and dermal cells as well as immune cells in the pathogenesis of cutaneous lupus erythematodes. 相似文献
65.
Asuka YOSHIMI Takashi TOGO Naoya SUGIYAMA Kumi UEHARA Tatsui OTSUKA Aya KARASHIMA Yoshio HIRAYASU 《Psychogeriatrics》2008,8(4):196-198
Tardive dyskinesia (TD) is a neurological disorder caused by the prolonged administration of dopamine antagonists, usually antipsychotics and especially first‐generation antipsychotics. Herein, we report on an elderly patient suffering from TD with depression induced by amoxapine, an antidepressant that antagonizes dopamine receptors. This case report demonstrates the therapeutic effect of donepezil even for TD due to amoxapine, corroborating the view that donepezil is beneficial for the treatment of TD induced by dopamine antagonists. A randomized placebo‐controlled double‐blind trial is required to confirm the usefulness of donepezil in the treatment of dopamine antagonist‐induced TD. 相似文献
66.
AOYAGI KUNIHIKO; OKAMURA SEIICHI; SHIBUYA TSUNEFUMI; MATSUGUCHI TETSUYA; TSUDA YASUO; YAMANO YUJIRO; OTSUKA TERUHISA; UEDA AKIRA; NIHO YOSHIYUKI 《Japanese journal of clinical oncology》1984,14(4):685-690
We treated a 52-year-old Japanese woman with adult T-cell leukemia(ATL) initiated with central nervous system (CNS) symptoms.Her chief complaints were paraplegia and left facial palsy.CNS-ATL was diagnosed because of the following three features.1) Various sized lymphoid cells with marked nuclear convolutionwere numerous in her cerebrospinal fluid. 2) These cells werea monoclonal proliferation of T lymphocytes with OKT 4 marker.3) The patient's serum was positive for anti-ATL associatedantigen (ATLA). Although the neurological signs and symptomsimproved markedly after intrathecal administration of combinedchemotherapy (methotrexate, cytarabine and corti-costeroid),these ATL cells were highly resistant to radiation therapy.The abdominal mass which developed in the course of the diseasewas diagnosed as a tumor formed of ATL cells, and VEPA (vincristine,endoxan, prednisolone and adriamycin) was administered withmarked success. 相似文献
67.
Difference in clinical features and HLA antigens between familial and non-familial vitiligo of non-segmental type 总被引:4,自引:0,他引:4
Of 131 patients with non-segmental vitiligo studied, 29 (22%) had a family history of this disorder. The clinical features and HLA antigens were assessed, and a comparison made between patients with familial and those with non-familial, non-segmental vitiligo. Familial patients developed skin lesions significantly earlier than non-familial patients. There was a significant association between HLA-B46 and familial non-segmental vitiligo, whereas HLA-A31 and CW4 were found in non-familial patients. The differences in clinical features and HLA phenotypes suggest heterogeneity in the pathogenic process between familial and non-familial vitiligo patients. 相似文献
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