Effects of Erythroid Hyperplasia on Patterns of Glycin-2-C14 Uptake in Heme and Globin of Human Peripheral Blood in Vivo

The rate of appearance of C¹⁴ in the heme and globin of peripheral bloodfollowing intravenous administration of glycine-2-C14 has been measured innormals and in patients with androgen-induced erythrocytosis, polycythemiavera (iron deficiency) and virilizing Cushing’s disease with polycythemia. Inall these cases of accelerated erythropoiesis a common alteration of the globinspecific activity curve was observed. Heme specific activity curves were notaffected.

The changes in the globin specific activity curves are best explained byconsideration of the marrow erythroid cellularity during erythrocytosis.

Submitted on August 6, 1965 Accepted on January 31, 1966     

Techniques and Methods for Catheter Endocardial Fulguration

Fulguration is a new and promising technique for the treatment of cardiac arrhythmias. This paper discusses the methods and equipment used at Jean Rostand Hospital for invasive experimental research related to fulguration. The importance of catheter testing and selection is demonstrated. The most important features of the measurement techniques for both His bundle and ventricular tachycardia recordings are described. The main components of the protocols for fulguration and early post-operative surveillance are reported. The ODAM Fulgucor is used, augmented by the incorporation of additional pieces of equipment to allow monitoring of current and voltage curves. An electromechanical relay allows for automatic switching from the recording amplifier to the energy source. The video system used includes recording of the image of the last fluoroscopic event with a character generator and an electronic pointer superimposed (when necessary). Computer programs for appropriate timing of predominant events have been developed.