全文获取类型
收费全文 | 390篇 |
免费 | 21篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 16篇 |
儿科学 | 28篇 |
妇产科学 | 4篇 |
基础医学 | 23篇 |
口腔科学 | 7篇 |
临床医学 | 38篇 |
内科学 | 102篇 |
皮肤病学 | 8篇 |
神经病学 | 11篇 |
特种医学 | 53篇 |
外科学 | 33篇 |
综合类 | 18篇 |
预防医学 | 17篇 |
眼科学 | 6篇 |
药学 | 39篇 |
肿瘤学 | 9篇 |
出版年
2023年 | 2篇 |
2018年 | 3篇 |
2016年 | 3篇 |
2015年 | 2篇 |
2014年 | 3篇 |
2013年 | 5篇 |
2012年 | 8篇 |
2011年 | 3篇 |
2010年 | 8篇 |
2009年 | 8篇 |
2008年 | 4篇 |
2007年 | 6篇 |
2001年 | 2篇 |
1999年 | 2篇 |
1998年 | 11篇 |
1997年 | 10篇 |
1996年 | 12篇 |
1995年 | 18篇 |
1994年 | 12篇 |
1993年 | 14篇 |
1992年 | 2篇 |
1991年 | 6篇 |
1990年 | 6篇 |
1989年 | 8篇 |
1988年 | 6篇 |
1987年 | 8篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1983年 | 3篇 |
1982年 | 8篇 |
1981年 | 5篇 |
1980年 | 10篇 |
1978年 | 3篇 |
1977年 | 6篇 |
1976年 | 3篇 |
1975年 | 6篇 |
1964年 | 2篇 |
1963年 | 2篇 |
1959年 | 16篇 |
1958年 | 31篇 |
1957年 | 27篇 |
1956年 | 23篇 |
1955年 | 24篇 |
1954年 | 16篇 |
1952年 | 1篇 |
1951年 | 1篇 |
1949年 | 8篇 |
1948年 | 19篇 |
1947年 | 1篇 |
1946年 | 2篇 |
排序方式: 共有412条查询结果,搜索用时 0 毫秒
91.
92.
TAM Kaandorp JJ Bax SE Bleeker J Doornbos EP Viergever D Poldermans EE van der Wall A de Roos HJ Lamb 《Journal of cardiovascular magnetic resonance》2010,12(1):7
Background
To assess the relationship between improved regional and global myocardial function in patients with ischemic cardiomyopathy in response to β-blocker therapy or revascularization.Materials and methods
Cardiovascular Magnetic Resonance (CMR) was performed in 32 patients with ischemic cardiomyopathy before and 8 ± 2 months after therapy. Patients were assigned clinically to β-blocker therapy (n = 20) or revascularization (n = 12). CMR at baseline was performed to assess regional and global LV function at rest and under low-dose dobutamine. Wall thickening was analyzed in dysfunctional, adjacent, and remote segments. Follow-up CMR included rest function evaluation.Results
Augmentation of wall thickening during dobutamine at baseline was similar in dysfunctional, adjacent and remote segments in both patient groups. Therefore, baseline characteristics were similar for both patient groups. In both patient groups resting LV ejection fraction and end-systolic volume improved significantly (p < 0.05) at follow-up. Stepwise multivariate analysis revealed that improvement in global LV ejection fraction in the β-blocker treated patients was significantly related to improved function of remote myocardium (p < 0.05), whereas in the revascularized patients improved function in dysfunctional and adjacent segments was more pronounced (p < 0.05).Conclusion
In patients with chronic ischemic LV dysfunction, β-Blocker therapy or revascularization resulted in a similar improvement of global systolic LV function. However, after β-blocker therapy, improved global systolic function was mainly related to improved contraction of remote myocardium, whereas after revascularization the dysfunctional and adjacent regions contributed predominantly to the improved global systolic function. 相似文献93.
TIMMIS A.D.; FOWLER M.B.; JAGGARAO N.S.V.; CHAMBERLAIN D.A. 《European heart journal》1980,1(6):413-416
The haemodynamic effects of labetalol infusion (mean dose 1mg/min) were measured in seven patients with sustained hypertensioncomplicating acute myocardial infarction. Four of the patientshad severe left ventricular failure. A fall in both systolic(mean 185 to 126 mm Hg) and diastolic (mean 87 to 68 mm Hg)blood pressure occurred in all patients. Cardiac index fellfrom 2.5 to 2.0 l/min/m2; systemic vascular resistance was notaffected. Heart rate slowed from 83 to 70 beats/ min. Labetalollowered pulmonary artery pressure in the patients with leftventricular failure. Labetalol is an effective antihypertensive agent in patientswith acute myocardial infarction and our results suggest itis safe provided cardiac output is within or near the normalrange. It seems not to be contraindicated in the presence ofpulmonary oedema. The effects imply that myocardial oxygen requirementswill be reduced. The implications for limitation of infarctsize in patients presenting early after acute infarction shouldbe determined. 相似文献
94.
Cerebral vasculitis--recognition, diagnosis and management 总被引:1,自引:0,他引:1
Scolding NJ; Jayne DR; Zajicek JP; Meyer PA; Wraight EP; Lockwood CM 《QJM : monthly journal of the Association of Physicians》1997,90(1):61-73
Cerebral vasculitis is a serious but uncommon condition which presents
considerable difficulties in recognition, diagnosis and treatment. We
studied eight consecutive patients in whom this diagnosis was made. Despite
the great diversity of symptoms and signs, we noted three clinical
patterns: (i) acute or sub-acute encephalopathy, (ii) a picture with some
similarities to multiple sclerosis ('MS-plus'), and (iii) features of a
rapidly progressive space-occupying lesion. The identification of these
patterns may help recognition of cerebral vasculitis. The diagnostic value
of four investigative procedures not previously studied in cerebral
vasculitis was assessed: ophthalmological examination using low-dose
fluorescein angiography with slit-lamp video microscopy of the anterior
segment (abnormal in 4/5 patients); spinal fluid oligoclonal band analysis
(abnormal in 3/6 patients); anti-neutrophil cytoplasmic antibody assay
(abnormal in 3/8 patients); and indium-labelled white-cell cerebral imaging
(positive in only one patient). Treatment was with steroid alone (n = 2) or
steroid with cyclophosphamide (n = 6). Seven patients responded clinically.
相似文献
95.
We report on the novel usage of intra-bursal tetracycline astreatment of olecranon bursitis in a pilot, open study of sevenpatients with RA. KEY WORDS: Olecranon bursitis, Tetracycline, Rheumatoid arthritis 相似文献
96.
The binding of bovine factor XII to kaolin 总被引:7,自引:0,他引:7
Purified bovine factor XII was radiolabeled with iodine-125 and its binding to kaolin studied. Binding was rapid and was not readily reversible upon adding unlabeled factor XII. The optimum pH for binding was in the region of pH 5-7. The isoelectric point of factor XII was pH 5.7. High concentrations of urea or increasing the ionic strength of the medium did not inhibit binding. Polyvalent macromolecules, such as Polybrene and polylysine, were effective inhibitors of factor XII binding to kaolin. Polylysine caused the release of factor XII that had bound to the kaolin surface. 相似文献
97.
98.
99.
100.