全文获取类型
收费全文 | 898560篇 |
免费 | 63479篇 |
国内免费 | 2327篇 |
专业分类
耳鼻咽喉 | 12475篇 |
儿科学 | 28676篇 |
妇产科学 | 26145篇 |
基础医学 | 126587篇 |
口腔科学 | 24683篇 |
临床医学 | 74757篇 |
内科学 | 183143篇 |
皮肤病学 | 18984篇 |
神经病学 | 71403篇 |
特种医学 | 36446篇 |
外国民族医学 | 336篇 |
外科学 | 142115篇 |
综合类 | 19029篇 |
一般理论 | 247篇 |
预防医学 | 64556篇 |
眼科学 | 20083篇 |
药学 | 63804篇 |
中国医学 | 1798篇 |
肿瘤学 | 49099篇 |
出版年
2018年 | 9049篇 |
2017年 | 7160篇 |
2016年 | 7675篇 |
2015年 | 8723篇 |
2014年 | 12368篇 |
2013年 | 19212篇 |
2012年 | 25654篇 |
2011年 | 27267篇 |
2010年 | 16577篇 |
2009年 | 15781篇 |
2008年 | 26128篇 |
2007年 | 27734篇 |
2006年 | 27915篇 |
2005年 | 27448篇 |
2004年 | 26295篇 |
2003年 | 25464篇 |
2002年 | 25052篇 |
2001年 | 41356篇 |
2000年 | 42553篇 |
1999年 | 36265篇 |
1998年 | 9966篇 |
1997年 | 9148篇 |
1996年 | 9084篇 |
1995年 | 8445篇 |
1994年 | 8081篇 |
1993年 | 7584篇 |
1992年 | 28198篇 |
1991年 | 26979篇 |
1990年 | 26408篇 |
1989年 | 25345篇 |
1988年 | 23553篇 |
1987年 | 23170篇 |
1986年 | 22250篇 |
1985年 | 21151篇 |
1984年 | 15806篇 |
1983年 | 13477篇 |
1982年 | 8087篇 |
1979年 | 14589篇 |
1978年 | 10208篇 |
1977年 | 8627篇 |
1976年 | 8147篇 |
1975年 | 8959篇 |
1974年 | 10697篇 |
1973年 | 10182篇 |
1972年 | 9661篇 |
1971年 | 8917篇 |
1970年 | 8584篇 |
1969年 | 8025篇 |
1968年 | 7684篇 |
1967年 | 7086篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
Nirmanmoh Bhatia Buddhadeb Dawn Tariq S. Siddiqui Marcus F. Stoddard 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2015,42(1):16-24
Determining aortic stenosis (AS) severity is clinically important. Calculating aortic valve (AV) area by means of the continuity equation assumes a circular left ventricular outflow tract (LVOT). The full impact of this assumption in calculating AV area is unknown. Predictors of noncircular LVOT shape in patients with AS are undefined.In 109 adult patients with AS who underwent multiplanar transesophageal echocardiography, we calculated AV area by means of the standard continuity method and by a modified method involving planimetric LVOT area.We found 54 circular, 37 horizontal-oval, 8 vertical-oval, and 10 irregular LVOTs. Area derived by direct planimetry correlated better with the modified than the standard continuity method (r=0.89 vs r=0.85; both P=0.0001). Valve areas of patients with mild, moderate, or severe AS by planimetry were more often mischaracterized with use of the standard than modified method (29 vs 18; P <0.0001). Horizontal-oval AV area derived by planimetry (1.28 ± 0.55 cm2) was underestimated by the standard method (1.05 ± 0.47 cm2; P=0.001), but not by the modified method. Congenital AV morphology and low cardiac index were the only multivariate predictors of horizontal-oval shape. Low cardiac index was the only predictor of noncircular shape.More than half our patients with AS had noncircular LVOTs. Using the modified method reduces mischaracterizations of AS severity. Congenital AV morphology and low cardiac index predict horizontal-oval or noncircular shape. These data suggest the value of direct LVOT measurement to calculate AS severity in patients who have congenital AV or a low cardiac index. 相似文献
102.
103.
Sebastian Mondaca Walid K. Chatila David Bates Jaclyn F. Hechtman Andrea Cercek Neil H. Segal Zsofia K. Stadler Anna M. Varghese Ritika Kundra Marinela Capanu Jinru Shia Nikolaus Schultz Leonard Saltz Rona Yaeger 《Clinical colorectal cancer》2019,18(1):e39-e52
Background
Treatment of advanced anal squamous cell cancer (SCC) is usually with the combination of cisplatin and 5-fluorouracil, which is associated with heterogeneous responses across patients and significant toxicity. We examined the safety and efficacy of a modified schedule, FOLFCIS (leucovorin, fluorouracil, and cisplatin), and performed an integrated clinical and genomic analysis of anal SCC.Patients and Methods
We reviewed all patients with advanced anal SCC receiving first-line FOLFCIS chemotherapy – essentially a FOLFOX (leucovorin, fluorouracil, and oxaliplatin) schedule with cisplatin substituted for oxaliplatin – in our institution between 2007 and 2017, and performed deep sequencing to identify genomic markers of response and key genomic drivers.Results
Fifty-three patients with advanced anal SCC (48 metastatic; 5 unresectable, locally advanced) received first-line FOLFCIS during this period; all were platinum-naive. The response rate was 48% (95% confidence interval [CI], 32.6%-63%). With a median follow-up of 41.6 months, progression-free survival and overall survival were 7.1 months (95% CI, 4.4-8.6 months) and 22.1 months (95% CI, 16.9-28.1 months), respectively. Among all patients with advanced anal SCC that underwent sequencing during the study period, the most frequent genomic alterations consisted of chromosome 3q amplification (51%) and mutations in PIK3CA (29%) and KMT2D (22%). No genomic alteration correlated with response to platinum-containing treatment. Although there were few cases, patients with human papillomavirus-negative anal SCC did not appear to benefit from FOLFCIS, and all harbored distinct genomic profiles with TP53, TERT promoter, and CDKN2A mutations.Conclusions
FOLFCIS appears effective and safe as first-line chemotherapy in patients with advanced anal SCC and represents an alternative treatment option for these patients. 相似文献104.
F. Murina R. Felice S. Di Francesco L. Nelvastellio I. Cetin 《Gynecological endocrinology》2020,36(5):431-435
AbstractThis study is a single-center, retrospective analysis of postmenopausal women presenting with dyspareunia and vulvar pain, aiming to evaluate relative effectiveness of vestibular CO2 laser therapy as a treatment. Three monthly sessions of laser were performed to each patient and thereafter a three-months follow-up was stablished. A total number of 72 patients undergoing vestibular laser treatment were recruited from patient files in the period between 2016 and 2018. Among these, 39 women also received a concomitant treatment with ospemifene (60?mg/day) during the study period. There was a statistically significant reduction of all the symptoms in both groups up to the three month follow-up. Regarding dryness and dyspareunia, the relief tent to be more prominent in the ospemifene?+?laser group at all follow-ups and remained statistically significant at three-month follow-up. Specifically, vestibular dryness was significantly lower in the ospemifene?+?laser group compared with the laser treatment group (?87% vs???34%, respectively), and the vestibular health score started declining faster in the ospemifene?+?laser group. Although, additional research is needed to understand the mechanism of action, our data shows that a combination regimen of laser and ospemifene may improve clinical effectiveness for long-term treatment of symptoms associated with the under-recognized genitourinary syndrome of menopause. 相似文献
105.
106.
107.
108.
109.
110.