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141.
Matthews DC; Appelbaum FR; Eary JF; Fisher DR; Durack LD; Bush SA; Hui TE; Martin PJ; Mitchell D; Press OW 《Blood》1995,85(4):1122-1131
In an attempt to decrease the relapse rate after bone marrow transplantation (BMT) for advanced acute leukemia, we initiated studies using 131I-labeled anti-CD45 antibody (BC8) to deliver radiation specifically to hematopoietic tissues, followed by a standard transplant preparative regimen. Biodistribution studies were performed in 23 patients using 0.5 mg/kg trace 131I-labeled BC8 antibody. The BC8 antibody was cleared rapidly from plasma with an initial disappearance half-time of 1.5 +/- 0.2 hours, presumably reflecting rapid antigen- specific binding. The mean radiation absorbed doses (cGy/mCi131I administered) were as follows: marrow, 7.1 +/- 0.8; spleen, 10.8 +/- 1.4; liver, 2.7 +/- 0.2; lungs, 2.1 +/- 0.1; kidneys, 0.7 +/- 0.1; and total body, 0.4 +/- 0.03. Patients with acute myelogenous leukemia (AML) in relapse had a higher marrow dose (11.4 cGy/mCi) than those in remission (5.2 cGy/mCi; P = .001) because of higher uptake and longer retention of radionuclide in marrow. Twenty patients were treated with a dose of 131I estimated to deliver 3.5 Gy (level 1) to 7 Gy (level 3) to liver, with marrow doses of 4 to 30 Gy and spleen doses of 7 to 60 Gy, followed by 120 mg/kg cyclophosphamide (CY) and 12 Gy total body irradiation (TBI). Nine of 13 patients with AML or refractory anemia with excess blasts (RAEB) and two of seven with acute lymphocytic leukemia (ALL) are alive disease-free at 8 to 41 months (median, 17 months) after BMT. Toxicity has not been measurably greater than that of CY/TBI alone, and the maximum tolerated dose has not been reached. This study demonstrates that with the use of 131I-BC8 substantially greater doses of radiation can be delivered to hematopoietic tissues as compared with liver, lung, or kidney, which may improve the efficacy of marrow transplantation. 相似文献
142.
Role of upstream DNase I hypersensitive sites in the regulation of human alpha globin gene expression 总被引:3,自引:1,他引:3
Erythroid-specific DNase 1 hypersensitive sites have been identified at the promoters of the human alpha-like genes and within the region from 4 to 40 kb upstream of the gene cluster. One of these sites, HS-40, has been shown previously to be the major regulator of tissue-specific alpha-globin gene expression. We have now examined the function of other hypersensitive sites by studying the expression in mouse erythroleukemia (MEL) cells of various fragments containing these sites attached to HS-40 and an alpha-globin gene. High level expression of the alpha gene was observed in all cases. When clones of MEL cells bearing a single copy of the alpha-globin gene fragments were examined, expression levels were similar to those of the endogenous mouse alpha genes and similar to MEL cells bearing beta gene constructs under the control of the beta-globin locus control region. However, there was no evidence that the additional hypersensitive sites increased the level of expression or conferred copy number dependence on the expression of a linked alpha gene in MEL cells. 相似文献
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During computed tomography (CT) pelvimetry of two pregnant women, bony abnormalities of the fetuses were noted on the scout images that were not confirmed at delivery. To explore the cause of these artifacts, specimen long bones were manipulated in various ways during CT scout imaging. Artifacts like those seen during in vivo imaging were found to be caused by motion of the object. The CT scout view is an example of an image produced by a digital system that uses a scanning beam. This type of digital system is being used for several types of body imaging including screening for scoliosis and chest radiography. Attention to motion artifacts should decrease diagnostic errors and aid further development of these systems. 相似文献
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Cerebral blood flow relationships associated with a difficult tone recognition task in trained normal volunteers 总被引:2,自引:2,他引:0
Holcomb HH; Medoff DR; Caudill PJ; Zhao Z; Lahti AC; Dannals RF; Tamminga CA 《Cerebral cortex (New York, N.Y. : 1991)》1998,8(6):534-542
Tone recognition is partially subserved by neural activity in the right
frontal and primary auditory cortices. First we determined the brain areas
associated with tone perception and recognition. This study then examined
how regional cerebral blood flow (rCBF) in these and other brain regions
correlates with the behavioral characteristics of a difficult tone
recognition task. rCBF changes were assessed using H2(15)O positron
emission tomography. Subtraction procedures were used to localize
significant change regions and correlational analyses were applied to
determine how response times (RT) predicted rCBF patterns. Twelve trained
normal volunteers were studied in three conditions: REST, sensory motor
control (SMC) and decision (DEC). The SMC-REST contrast revealed bilateral
activation of primary auditory cortices, cerebellum and bilateral inferior
frontal gyri. DEC-SMC produced significant clusters in the right middle and
inferior frontal gyri, insula and claustrum; the anterior cingulate gyrus
and supplementary motor area; the left insula/claustrum; and the left
cerebellum. Correlational analyses, RT versus rCBF from DEC scans, showed a
positive correlation in right inferior and middle frontal cortex; rCBF in
bilateral auditory cortices and cerebellum exhibited significant negative
correlations with RT These changes suggest that neural activity in the
right frontal, superior temporal and cerebellar regions shifts back and
forth in magnitude depending on whether tone recognition RT is relatively
fast or slow, during a difficult, accurate assessment.
相似文献
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