全文获取类型
收费全文 | 1876篇 |
免费 | 115篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 117篇 |
妇产科学 | 91篇 |
基础医学 | 211篇 |
口腔科学 | 47篇 |
临床医学 | 188篇 |
内科学 | 468篇 |
皮肤病学 | 30篇 |
神经病学 | 156篇 |
特种医学 | 102篇 |
外科学 | 215篇 |
综合类 | 17篇 |
一般理论 | 1篇 |
预防医学 | 148篇 |
眼科学 | 20篇 |
药学 | 100篇 |
中国医学 | 3篇 |
肿瘤学 | 75篇 |
出版年
2022年 | 13篇 |
2021年 | 35篇 |
2020年 | 32篇 |
2019年 | 38篇 |
2018年 | 51篇 |
2017年 | 35篇 |
2016年 | 40篇 |
2015年 | 43篇 |
2014年 | 39篇 |
2013年 | 73篇 |
2012年 | 105篇 |
2011年 | 139篇 |
2010年 | 80篇 |
2009年 | 56篇 |
2008年 | 111篇 |
2007年 | 118篇 |
2006年 | 85篇 |
2005年 | 81篇 |
2004年 | 63篇 |
2003年 | 55篇 |
2002年 | 54篇 |
2001年 | 58篇 |
2000年 | 47篇 |
1999年 | 37篇 |
1998年 | 29篇 |
1997年 | 33篇 |
1996年 | 29篇 |
1995年 | 27篇 |
1994年 | 21篇 |
1993年 | 19篇 |
1992年 | 24篇 |
1991年 | 15篇 |
1990年 | 25篇 |
1989年 | 34篇 |
1988年 | 26篇 |
1987年 | 33篇 |
1986年 | 18篇 |
1985年 | 19篇 |
1984年 | 11篇 |
1983年 | 13篇 |
1982年 | 9篇 |
1979年 | 13篇 |
1978年 | 13篇 |
1977年 | 14篇 |
1976年 | 12篇 |
1975年 | 9篇 |
1974年 | 9篇 |
1971年 | 8篇 |
1970年 | 8篇 |
1966年 | 8篇 |
排序方式: 共有2010条查询结果,搜索用时 10 毫秒
61.
Jos-Ramn Blanco Ramn Morillo Vicente Abril Ismael Escobar Enrique Bernal Carlos Folguera Ftima Braas Mercedes Gimeno Olatz Ibarra Jos-Antonio Iribarren Alicia Lzaro Ana Mario Mara-Teresa Martn Esteban Martinez Luis Ortega Julian Olalla Aguas Robustillo Matilde Sanchez-Conde Miguel-Angel Rodriguez Javier de la Torre Javier Sanchez-Rubio Montse Tuset 《European journal of clinical pharmacology》2020,76(3):305-318
62.
Luis A. González Yulieth A. Upegui Luis Rivas Fernando Echeverri Gustavo Escobar Sara M. Robledo Wiston Quiñones 《Archiv der Pharmazie》2020,353(12):2000157
Chalcones are a group of natural products with many recognized biological activities, including antiparasitic activity. Although a lot of chalcones have been synthetized and assayed against parasites, the number of structural features known to be involved in this biological property is small. Thus, in the present study, 21 chalcones were synthesized to determine the effect of substituents in the A and B rings on the activity against Leishmania braziliensis, Trypanosoma cruzi, and Plasmodium falciparum. The compounds were active against L. braziliensis in a structure-dependent manner. Only one compound was very active against T. cruzi, but none of them had a significant antiplasmodial activity. The electron-donating substituents in ring B and the hydrogen bonds at C-2′ with carbonyl affect the antiparasitic activity. 相似文献
63.
64.
Gomez-Diez SG López LG Escobar ML Gutiérrez LJ Oliva NP 《Medicina oral, patología oral y cirugía bucal》2007,12(8):E602-E604
Progressive facial hemiatrophy (PFH) is a rare condition characterized by the slow, progressive appearance of a unilateral facial atrophy that affects the skin, subcutaneous tissue, muscle and bone. We report the case of a 60-year-old female patient whose cutaneous symptoms commenced in 1987 in the form of a purplish erythema on the left side of her face and neck, which subsequently remitted giving rise to an indurated region in the left maxillary region. Since 1995 until the present day, she has developed facial hemiatrophy on the left side accompanied by progressive osseous reabsorption of the upper maxilla and left mandible with atrophy of soft tissue. The association of the onset of PFH with progressive osteolysis of the maxilla has not been previously reported in an adult patient. 相似文献
65.
Bibiana Escobar Pilar Taurá Graciela Martínez-Palli Constatino Fondevila Jaume Balust Joan Beltrán Javier Fernández Juan Carlos García-Pagán Juan Carlos García-Valdecasas 《World journal of surgery》2014,38(4):927-935
Introduction
In patients with advanced cirrhosis, stressful stimuli may reveal a silent reduced cardiac performance. During liver transplantation (LT), graft reperfusion strongly stresses the heart and may unmask latent myocardial dysfunction.Aim
The objective of this study was to assess heart response to acutely increased preload after liver graft reperfusion and correlate this response with preoperative data and outcome.Methods
Preoperative clinical, echocardiographic, and hemodynamic data, and patient outcome were retrospectively recorded for 235 liver recipients who had no known cardiac disease. Myocardial dysfunction was defined as less than 10 % increase of stroke volume after graft reperfusion (non-responder).Results
We found 84 (35.7 %) non-responder patients. The non-responders showed higher Model for end-stage liver disease scores (p = 0.046), left atrial diameter (LAD) (p = 0.040), hepatic vein pressure gradient (p = 0.055), and hyperdynamic state than responders. The percentages of patients with hyponatremia (p = 0.048) and alcohol etiology (p = 0.025) were also higher among non-responders. Independent predictors of inadequate cardiac response in the multivariate analysis were low preoperative systemic vascular resistance (SVRI) [odds ratio (OR) 3.09, 95 % CI 1.15–4.82; p = 0.027] and enlargement of LAD (OR 2.08, 95 % CI 1.49–2.74; p = 0.044). Non-response was associated with higher rates of early cardiovascular events [hazard ratio (HR) 2.84, 95 % CI 1.09–4.22; p = 0.039] and higher length of intensive care unit stay (p = 0.038). No differences were found in 1-year survival rates.Conclusions
Latent cardiac dysfunction among LT recipients, considered to be abnormal stroke volume response to unclamping of portal vein, is very prevalent. SVRI and LAD were independent predictors of inadequate responses. This condition deserves special attention since it may aggravate the early postoperative course of LT. 相似文献66.
67.
68.
69.
Vincent P. Diego Bernadette W. Luu Marco Hofmann Long V. Dinh Marcio Almeida Jerry S. Powell Raja Rajalingam Juan M. Peralta Satish Kumar Joanne E. Curran Zuben E. Sauna Roberta Kellerman Yara Park Nigel S. Key Miguel A. Escobar Huy Huynh Anne M. Verhagen Sarah Williams‐Blangero Paul V. Lehmann Eugene Maraskovsky John Blangero Tom E. Howard 《Journal of thrombosis and haemostasis》2020,18(1):201-216