全文获取类型
收费全文 | 1868篇 |
免费 | 119篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 21篇 |
儿科学 | 117篇 |
妇产科学 | 90篇 |
基础医学 | 211篇 |
口腔科学 | 47篇 |
临床医学 | 188篇 |
内科学 | 467篇 |
皮肤病学 | 30篇 |
神经病学 | 156篇 |
特种医学 | 102篇 |
外科学 | 215篇 |
综合类 | 17篇 |
一般理论 | 1篇 |
预防医学 | 147篇 |
眼科学 | 20篇 |
药学 | 100篇 |
中国医学 | 3篇 |
肿瘤学 | 74篇 |
出版年
2022年 | 10篇 |
2021年 | 35篇 |
2020年 | 32篇 |
2019年 | 38篇 |
2018年 | 51篇 |
2017年 | 35篇 |
2016年 | 40篇 |
2015年 | 43篇 |
2014年 | 39篇 |
2013年 | 73篇 |
2012年 | 105篇 |
2011年 | 139篇 |
2010年 | 80篇 |
2009年 | 56篇 |
2008年 | 111篇 |
2007年 | 118篇 |
2006年 | 85篇 |
2005年 | 81篇 |
2004年 | 63篇 |
2003年 | 55篇 |
2002年 | 54篇 |
2001年 | 58篇 |
2000年 | 47篇 |
1999年 | 37篇 |
1998年 | 29篇 |
1997年 | 33篇 |
1996年 | 29篇 |
1995年 | 27篇 |
1994年 | 21篇 |
1993年 | 19篇 |
1992年 | 24篇 |
1991年 | 15篇 |
1990年 | 25篇 |
1989年 | 34篇 |
1988年 | 26篇 |
1987年 | 33篇 |
1986年 | 18篇 |
1985年 | 19篇 |
1984年 | 11篇 |
1983年 | 13篇 |
1982年 | 9篇 |
1979年 | 13篇 |
1978年 | 13篇 |
1977年 | 14篇 |
1976年 | 12篇 |
1975年 | 9篇 |
1974年 | 9篇 |
1971年 | 8篇 |
1970年 | 8篇 |
1966年 | 8篇 |
排序方式: 共有2006条查询结果,搜索用时 288 毫秒
21.
Two additional families with popliteal pterygium syndrome are presented. Using previously published pedigrees, as well as the ones reported here, evidence is presented that supports an autosomal dominant mode of inheritance for this syndrome. Analysis of previous familial cases showed a large degree of between and within-family variation. The segregation analysis supports the dominant hypothesis (P=0.5). 相似文献
22.
Sequence comparison of human and yeast telomeres identifies structurally distinct subtelomeric domains 总被引:6,自引:2,他引:6
Flint J; Bates GP; Clark K; Dorman A; Willingham D; Roe BA; Micklem G; Higgs DR; Louis EJ 《Human molecular genetics》1997,6(8):1305-1313
We have sequenced and compared DNA from the ends of three human
chromosomes: 4p, 16p and 22q. In all cases the pro-terminal regions are
subdivided by degenerate (TTAGGG)n repeats into distal and proximal sub-
domains with entirely different patterns of homology to other chromosome
ends. The distal regions contain numerous, short (<2 kb) segments of
interrupted homology to many other human telomeric regions. The proximal
regions show much longer (approximately 10-40 kb) uninterrupted homology to
a few chromosome ends. A comparison of all yeast subtelomeric regions
indicates that they too are subdivided by degenerate TTAGGG repeats into
distal and proximal sub-domains with similarly different patterns of
identity to other non-homologous chromosome ends. Sequence comparisons
indicate that the distal and proximal sub-domains do not interact with each
other and that they interact quite differently with the corresponding
regions on other, non- homologous, chromosomes. These findings suggest that
the degenerate TTAGGG repeats identify a previously unrecognized,
evolutionarily conserved boundary between remarkably different subtelomeric
domains.
相似文献
23.
Sá DR Souza-Santos R Escobar AL Coimbra CE 《Bulletin de la Societe de pathologie exotique (1990)》2005,98(1):28-32
This paper reports the results of a longitudinal study of malaria incidence (1998-2002) among the Pakaanóva (Wari') Indians, Brazilian southwest Amazon region, based on data routinely gathered by Brazilian National Health Foundation outposts network in conjunction with the Indian health service. Malaria is present yearlong in the Pakaanóva. Statistically significant differences between seasons or months were not noticed. A total of 1933 cases of malaria were diagnosed in the Pakaanóva during this period. The P. vivax / P. falciparum ratio was 3.4. P. vivax accounted for 76.5% of the cases. Infections with P. malariae were not recorded. Incidence rates did not differ by sex. Most malaria cases were reported in children < 10 years old (45%). About one fourth of all cases were diagnosed on women 10-40 years old. An entomological survey carried out at two Pakaanóva villages yielded a total of 3.232 specimens of anophelines. Anopheles darlingi predominated (94.4%). Most specimens were captured outdoors and peak activity hours were noted at early evening and just before sunrise. It was observed that Pakaanóva cultural practices may facilitate outdoor exposure of individuals of both sexes and all age groups during peak hours of mosquito activities (e.g., coming to the river early in the morning for bathing or to draw water, fishing, engaging in hunting camps, etc). In a context in which anophelines are ubiquitous and predominantly exophilic, and humans of both sexes and all ages are prone to outdoor activities during peak mosquito activity hours, malaria is likely to remain endemic in the Pakaanóva, thus requiring the development of alternative control strategies that are culturally and ecologically sensitive. 相似文献
24.
Javier I. Escobar David J. Lakatua Barbara Streifel Norman L. Virnig Otto Sanchez 《Clinical genetics》1977,11(1):8-12
An abnormal chromosome No. 2 was found in the case of a child with an imperforate anus, a recto-vaginal fistula, unilateral atresia of the inner canal, and deformity of the external ear. G-banding studies revealed an insertion of a segment of the short arm into the long arm in one of the chromosomes No. 2 of the proband, the apparent result of a de novo phenomenon of chromosome rearrangement. 相似文献
25.
On the classification of the acrocephalosyndactyly syndromes 总被引:2,自引:0,他引:2
This report describes a family in which two different types of acrocephalosyndactyly (ACS) were clinically identified. The proband presented with the classic stigmata of Pfeiffer syndrome, while her cousin was considered to be a typical case of Apert syndrome. Seven other family members also have unusually shaped heads and the facial appearance reminiscent of Crouzon disease.
Observations made in this family and from previous reports in the literature, we feel there is substantial reason to re-evaluate the ACS classification and to consider that the Apert and Pfeiffer types of ACS may be one and the same. 相似文献
Observations made in this family and from previous reports in the literature, we feel there is substantial reason to re-evaluate the ACS classification and to consider that the Apert and Pfeiffer types of ACS may be one and the same. 相似文献
26.
L. Torres S. Escobar A. López M. Marco V. Pobo 《European journal of clinical microbiology & infectious diseases》2002,21(7):537-538
Vibrio vulnificus is a gram-negative rod that can cause septicaemia and skin lesions, usually in patients with underlying illnesses such as
chronic liver disease or diabetes mellitus. Infections caused by this bacterium are unusual in Spain. A case of skin infection
due to Vibrio vulnificus is reported in a patient whose abraded skin on his left leg came into contact with seawater. The patient died suddenly, probably
due to septicaemia or bacteraemia caused by this organism. Vibrio vulnificus infection must be considered in the differential diagnosis of septicaemia, skin lesions and wound infections, particularly
when a patient reports a history of contact with seawater.
Electronic Publication 相似文献
27.
28.
Entrainment by a palatable meal induces food-anticipatory activity and c-Fos expression in reward-related areas of the brain 总被引:2,自引:0,他引:2
Rats maintained under restricted feeding schedules (RFS) develop food-anticipatory activity and entrainment of physiological parameters. Food entrainment is independent of the suprachiasmatic nucleus and depends on food-entrainable oscillators (FEO). Restricted feeding schedules lead animals toward a catabolic state and to increase their food driven motivation, suggesting that in this process metabolic- and reward-related mechanisms are implicated. This study explored if motivation driven by a palatable meal is sufficient to produce food-entrainment. To address this question, we evaluated whether daily fixed access to a highly palatable meal entrained (PME) locomotor activity, serum glucose and free fatty acids concentrations in rats maintained without food deprivation. The entrained response of PME rats was compared with rats entrained to RFS. In a second experiment, we used c-Fos-IR to identify structures in the central nervous system involved with PME. Rats showed anticipatory activity to a daily palatable meal, with a lower intensity than rats entrained to RFS. Anticipatory activity persisted at least for four cycles after interrupting palatable meal, suggesting that this persistence depends on an endogenous oscillator. Glucose and free fatty acids were not entrained in PME rats. c-Fos expression in limbic system nuclei was in phase with PME time, but not in the hypothalamus. Results suggest 1) that food deprivation, i.e. a catabolic state is not necessary for the expression of anticipatory activity; 2) that an increase in the motivational state due to taste and/or nutritional contents of palatable meal is sufficient to entrain behavior; and 3) that structures in the limbic system are involved in this entrainment process. The present study indicates that metabolic and motivational mechanisms are involved in food entrainment, and suggests that the FEO may be a multi-oscillatory system distributed over different regulatory systems in the brain. 相似文献
29.