Brain-Derived Neurotrophic Factor Gene Val66Met Polymorphism Is a Risk Factor for Attention-Deficit Hyperactivity Disorder in a Turkish Sample

ObjectiveAttention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that negatively affects different areas of life. We aimed to evaluate the associations between the Val66Met polymorphism of brain-derived neurotrophic factor (BDNF) and ADHD and to assess the effect of the BDNF polymorphism on the neurocognitive profile and clinical symptomatology in ADHD.MethodsTwo hundred one ADHD cases and 99 typically developing subjects (TD) between the ages of 8 and 15 years were involved in the study. All subjects were evaluated using a complete neuropsychological battery, Child Behavior Checklist, the Teacher''s Report Form (TRF) and the DSM-IV Disruptive Behavior Disorders Rating Scale-teacher and parent forms.ResultsThe GG genotype was significantly more frequent in the patients with ADHD than in the TD controls, and the GG genotype was also significantly more frequent in the ADHD-combined (ADHD-C) subtype patients than in the TDs. However, there were no significant associations of the BDNF polymorphism with the ADHD subtypes or neurocognitive profiles of the patients. The teacher-assessed hyperactivity and inattention symptom count and the total score were higher, and the appropriately behaving subtest score of the TRF was lower in the GG genotypes than in the GA and AA (i.e., the A-containing) genotypes.ConclusionWe found a positive association between the BDNF gene Val66Met polymorphism and ADHD, and this association was observed specifically in the ADHD-C subtype and not the ADHD-predominantly inattentive subtype. Our findings support that the Val66Met polymorphism of BDNF gene might be involved in the pathogenesis of ADHD. Furthermore Val66Met polymorphism of BDNF gene may be more closely associated with hyperactivity rather than inattention.     

Chronic pelvic pain: gynaecological and non‐gynaecological causes and considerations for nursing care

Chronic pelvic pain (CPP) is one of the most difficult problems encountered by health professionals, and it is a very common gynaecological complaint in women of reproductive age. Any structure in the abdomen and/or pelvis could have a role in aetiology of CPP. The aetiology, however, is often unclear and the origin seems can be multifactorial. A multidisciplinary team can offer simultaneous assessment and management of somatic, behavioural and psychosocial components of the pain, and the nurse as an integral member of the healthcare team has an important role to play in ensuring effective care provision. The purpose of this review is to present comprehensive and contemporary information about the gynaecological and non‐gynaecological causes of CPP alongside an examination of the role of the nurse in caring for women who experience this problem.     

Analyzing the Links Between Problematic Social Media Use,Dark Triad Traits,and Self-esteem

International Journal of Mental Health and Addiction - Social media use, which is regarded as a popular leisure activity around the world, brings about the risk of becoming problematic in its wake,...