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991.
Virginie Nerich PharmD PhD Christophe Guyeux PhD Michel Henry-Amar MD PhD Raphaël Couturier PhD Catherine Thieblemont MD PhD Vincent Ribrag MD PhD Hervé Tilly MD PhD Corinne Haioun MD PhD René-Olivier Casasnovas MD PhD Franck Morschhauser MD PhD Pierre Feugier MD PhD David Sibon MD PhD Loic Ysebaert MD PhD Emmanuelle Nicolas-Virelizier MD PhD Florence Broussais-Guillaumot MD Gandhi L. Damaj MD PhD Jean-Philippe Jais MD PhD Gilles Salles MD PhD Macha Woronoff-Lemsi PharmD PhD Nicolas Mounier MD PhD 《Cancer》2022,128(3):519-528
992.
Vincent?SibaudEmail author Nicole?R.?Leb?uf Henri?Roche Viswanath?R.?Belum Laurence?Gladieff Marion?Deslandres Marion?Montastruc Audrey?Eche Emmanuelle?Vigarios Florence?Dalenc Mario?E.?Lacouture 《European journal of dermatology : EJD》2016,26(5):427-443
Taxanes (docetaxel and paclitaxel) are among the most commonly prescribed anticancer drugs approved for the treatment of metastatic or locally advanced breast, non-small cell lung, prostate, gastric, head and neck, and ovarian cancers, as well as in the adjuvant setting for operable node-positive breast cancers. Although the true incidence of dermatological adverse events (AEs) in patients receiving taxanes is not known, and has never been prospectively analysed, they clearly represent one of the major AEs associated with these agents. With an increase in the occurrence of cutaneous AEs during treatment with novel targeted and immunological therapies when used in combination with taxanes, a thorough understanding of reactions attributable to this class is imperative. Moreover, identification and management of dermatological AEs is critical for maintaining the quality of life in cancer patients and for minimizing dose modifications of their antineoplastic regimen. This analysis represents a systematic review of the dermatological conditions reported with the use of these drugs, complemented by experience at comprehensive cancer centres. The conditions reported herein include skin, hair, and nail toxicities. Lastly, we describe the dermatological data available for the new, recently FDA-and EMA- approved, solvent-free nab-paclitaxel. 相似文献
993.
R. Hilfiker I. A. Knutti B. Raval-Roland G. Rivier G. Crombez Emmanuelle Opsommer 《European spine journal》2016,25(9):2741-2749
Purpose
The assessment of a broad range of biopsychosocial aspects is important in the rehabilitation of patients with chronic low back pain (CLBP) for the prediction of outcome as well as for evaluation. The objective of this study was to test the responsiveness, construct validity and predictive value of the Örebro Musculoskeletal Pain Screening Questionnaire (OMPSQ) compared to other instruments widely used to assess biopsychosocial aspects in patients with CLBP.Methods
111 patients with CLBP admitted to an inpatient rehabilitation completed a set of questionnaires on biopsychosocial aspects at baseline and at discharge. Ninety-eight patients responded at three months for an assessment of the return to work status. Responsiveness of the OMPSQ, the ability to detect change in the construct of interest, was investigated by a set of hypotheses on correlations with widely used questionnaires. We tested the hypothesis that the changes in the OMPSQ would vary along with the responses in the Patient’s Global Impression of Change. Prediction of disability at discharge, work status at three months and time to return to work was evaluated with linear, logistic and cox regression models.Results
The OMPSQ showed good predictive values for disability and return to work and construct validity of the instrument was corroborated. Seventy-nine percent of our hypotheses for responsiveness could be confirmed, with the OMPSQ showing the second highest change during the rehabilitation.Conclusions
The OMPSQ can also be applied in patients with CLBP, but for the assessment of change in psychosocial variables one should add specific questionnaires.994.
Anne-Claire Museux Serge Dumont Emmanuelle Careau Élise Milot 《Social work in health care》2016,55(6):427-439
This article examines the effects of nonviolent communication (NVC) training on the interprofessional collaboration (IPC) of two health and social services sector care teams. The study was conducted in 2013 with two interprofessional teams (N = 9) using a mixed method research design to measure the effects of the training. Individual IPC competency was measured using the Team Observed Structured Clinical Encounter tool, and group competency using the Observed Interprofessional Collaboration tool. A focus group was held to collect participant perceptions of what they learned in the training. Results revealed improvements in individual competency in client/family-centered collaboration and role clarification. Improvements in group competency were also found with respect to teams’ ability to develop a shared plan of action. Data suggests that participants accepted and adopted training content. After the training, they appeared better able to identify the effects of spontaneous communication, more understanding of the mechanisms of empathy, and in a better position to foster collective leadership. 相似文献
995.
996.
Ghedira ES Dupin-Deguine D Duffilot D Lemetayer N Faubert E Pissard S 《Hemoglobin》2011,35(2):157-161
The preparation of a prenatal diagnosis in a family of North-African origin in which a child received a bone marrow transplant for β-thalassemia major (β-TM), prompted us to make the molecular diagnosis in the parents and siblings. Molecular and phenotype assays were carried on blood samples from the parents and the proband's sister. The father, a 45-year-old man, was found to be heterozygous for a rare mutation in exon 2 [codon 46 (+A), HBB:c.138_139insA] creating a frameshift, while the mother and sister were found to be carriers of the common codon 39 (C>T) stop mutation (HBB:c.118C>T). Because of the bone marrow transplant, proband genotyping was done from a buccal swab and revealed that he is a compound heterozygote for both the codon 46 and codon 39 mutations. In the parents and sister, hematological parameters were those of a thalassemia minor in agreement with the two β(0) mutations found in the family. 相似文献
997.
998.
In France, numerous HIV patients still discover their HIV status as a result of AIDS-related symptoms. We investigated factors related to the absence of any HIV testing in men and women separately, using the data from the SIRS cohort, which includes 3023 households representative of the Paris metropolitan area in 2005. The failure to use HIV testing services was studied in relation to individual socio-economic and demographic factors as well as some psychosocial characteristics. The effect of the characteristics of the residential neighbourhood was also analysed using multilevel models. In multivariate analysis, the factors associated with no history of HIV testing in women were an age >44 years, the absence of any pregnancy during the previous 15 years, a low education level, unemployment, to have had no or only one steady relationship in one's lifetime, to have a religious affiliation and to live in a poor neighbourhood. In men, factors were age <30 or >44 years, to have had no or only one steady relationship during one's lifetime, to have a religious affiliation and to perceive oneself as being at low risk of HIV infection. An association according to the "migration origin" was observed among men: foreigners and French men born to (at least) one foreign parent were more likely not to have been tested than French men born to two French parents. We conclude that gender, social and territorial differences exist in HIV testing among people living in the Paris area. More systematic proposals of HIV test in primary care would be an effective policy to overcome these persistent social stratifications. 相似文献
999.
Duplessis S Cuomo CA Lin YC Aerts A Tisserant E Veneault-Fourrey C Joly DL Hacquard S Amselem J Cantarel BL Chiu R Coutinho PM Feau N Field M Frey P Gelhaye E Goldberg J Grabherr MG Kodira CD Kohler A Kües U Lindquist EA Lucas SM Mago R Mauceli E Morin E Murat C Pangilinan JL Park R Pearson M Quesneville H Rouhier N Sakthikumar S Salamov AA Schmutz J Selles B Shapiro H Tanguay P Tuskan GA Henrissat B Van de Peer Y Rouzé P Ellis JG Dodds PN Schein JE Zhong S Hamelin RC Grigoriev IV Szabo LJ 《Proceedings of the National Academy of Sciences of the United States of America》2011,108(22):9166-9171
1000.
Brain EG Mertens C Girre V Rousseau F Blot E Abadie S Uwer L Bourbouloux E Van Praagh-Doreau I Mourey L Kirscher S Laguerre B Fourme E Luneau S Genève J Debled M 《Critical reviews in oncology/hematology》2011,80(1):160-170