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81.
Emel Altuncu Su Berrak Hülya Bilgen Ziya Yurdakul Cengiz Canpolat Eren Ozek 《The journal of maternal-fetal & neonatal medicine》2007,20(8):627-629
Activated recombinant factor VIIa was administered to a preterm infant with bleeding diasthesis and a huge subdural hematoma that could not be controlled by the blood products. The coagulation tests were normalized the following day. Recombinant factor VIIa can be a choice in selected cases with intractable bleedings unesponsive to conventional replacement therapy. 相似文献
82.
Andac Salman Emel Kurt Volkan Topcuoglu Zeynep Demircay 《American journal of clinical dermatology》2016,17(3):305-311
Background
Vitiligo and acne vulgaris, commonly affecting the face, have significant psychological effects and impair the quality of life of the affected individuals. Because of their negative effect on physical appearance, these conditions may act as a potential barrier to social relationships and cause social anxiety.Objective
The objective of the study was to investigate the social anxiety, quality of life, anxiety, and depression levels of acne and vitiligo patients with facial involvement and compare these levels with healthy controls.Methods
Thirty-seven vitiligo and 37 acne patients, aged older than 18 years, with facial involvement and 74 age- and sex-matched healthy control subjects were included in the study. The patients and healthy controls were asked to complete the Liebowitz Social Anxiety Scale, the Hospital Anxiety and Depression Scale, and the Dermatology Life Quality Index. Disease severity was evaluated both objectively by the physician and subjectively by the patients using a visual analog scale.Results
Social anxiety, depression, and anxiety levels of vitiligo and acne patients were significantly higher than healthy controls (p < 0.05). Quality of life was impaired in both patient groups (Dermatology Life Quality Index scores for vitiligo: 5.6 ± 5.1; acne: 6.4 ± 6.2). There was no correlation between psychiatric scale scores and disease severity. Quality of life was negatively correlated with social anxiety and depression levels in both patient groups in our study.Conclusion
Vitiligo and acne patients had higher levels of social anxiety, anxiety, and depression compared with healthy control subjects. Considering that increased psychosocial morbidity was regardless of age, sex, and disease severity and was correlated with quality of life impairment, evaluation of the psychosocial morbidity, in particular social anxiety, may be valuable in all vitiligo and acne patients.83.
Pamuk ON Pamuk GE Altiparmak MR Sonsuz A Solakoğlu S Kiliçaslan I 《Leukemia & lymphoma》2002,43(3):661-663
Extramedullary hematopoiesis being an important feature of agnogenic myeloid metaplasia (AMM), a chronic myeloproliferative disease of clonal origin, may affect the kidneys, but this condition is usually asymptomatic. Until now, there is only one reported case of nephrotic syndrome associated with AMM. We present a patient with AMM who had nephrotic syndrome and whose renal biopsy revealed membranous glomerulonephritis together with renal extramedullary hematopoiesis. 相似文献
84.
85.
Goldenhar's Syndrome (oculo-auriculo-vertebral dysplasia) is a wide spectrum of congenital anomalies that involves structures arising from the first and second branchial arches. In this report, a case of a male infant, with the features of hemi facial microsomia, anotia, vertebral anomalies, congenital facial nerve palsy and lagophthalmos is described. Although the syndrome itself is not uncommon, the presence of congenital facial nerve palsy, which has been reported in rare cases, prompted this case report. 相似文献
86.
87.
The aim of the present work was to evaluate structural and metabolic changes in histaminergic neurons in hypothalamic nucleus
E2 in rats in conditions of complete external drainage of bile. Studies were performed on male Wistar rats (n = 45). Controls consisted of animals subjected to sham surgery with preservation of physiological bile flow throughout the
experiment. Quantitative histological and histochemical methods were used. Serial frontal cryostat sections cut from the posterior
hypothalamus were used for detection of the activity of the following enzymes: monoamine oxidase B, succinate dehydrogenase,
NADH dehydrogenase, NADPH dehydrogenase, glucose-6-phosphate dehydrogenase, lactate dehydrogenase, and acid phosphatase. Morphological
studies of histaminergic neurons were performed on preparations stained with thionine. These studies showed that complete
external drainage of bile led to transient size reductions and rounding of cell perikarya. Metabolic changes were seen within
a day of bile loss and subsequently progressed. All energy metabolic pathways were suppressed and acid phosphatase activity
was increased on day 5.
__________
Translated from Morfologiya, Vol. 132, No. 6, pp. 22–25, November–December, 2007. 相似文献
88.
Melih Güven Güvenç Kenan Midilli Ender Inci Mert Kuşkucu Rauf Tahamiler Emel Özergil Sevgi Ergin Mehmet Ada Kemal Altaş 《Auris, nasus, larynx》2010
Objective
To investigate the presence of Chlamydophila pneumoniae and other bacterial pathogens in middle ear effusion samples obtained from children with otitis media with effusion (OME).Materials and methods
Twenty-eight children (mean age 7.03; standard deviation 2.18) with OME unresponsive to medical therapy were included in the study. All of the children underwent ventilation tube insertion under general anesthesia. Eighteen patients were bilaterally affected whereas 10 children had unilateral disease. The middle ear fluids (46 samples in total) were collected during ventilation tube insertion, and were evaluated subsequently for the presence of C. pneumoniae and other bacterial pathogens using polymerase chain reaction (PCR).Results
Although all samples were negative for C. pneumoniae, bacterial DNA was detected in 21 of 46 samples. Overall 40% of the patients (4/10) with unilateral involvement, and 61% of the patients (11/18) with bilateral involvement were positive for bacterial DNA. In 6 patients with bilateral OME bilateral samples were positive, whereas 5 patients with bilateral OME showed only unilateral positivity. According to the results of DNA sequencing analysis, all of the positive samples harbored only one bacterial species. In 12 of 46 samples Alloiococcus otitidis DNA (26%), in 7 Haemophilus influenzae DNA (15%), in one Streptoccoccus pneumoniae DNA (2%) and in one Moraxella catarrhalis DNA (2%) were present.Conclusions
Our findings support that C. pneumoniae does not seem to have a role in OME in children whereas A. otitidis was found to be more frequent than the other common pathogens. Further studies are required to elucidate the exact pathogenetic role of these microorganisms in OME. 相似文献89.
Mehmet Şahin Emel Şahin Saadet Gümüşlü Abdullah Erdoğan Meral Gültekin 《Cancer metastasis reviews》2010,29(4):655-676
Metastasis is a leading cause of mortality and morbidity in cancer. This process needs angiogenesis. The biology underlying
cancer, metastasis, and angiogenesis has been investigated so as to determine the therapeutic targets. Invasive and metastatic
cancer cells have undergone numerous genetic and epigenetic changes, manifested by cytoskeletal changes, loss of adhesion,
and expression of proteolytic enzymes that degrade the basement membrane. Additionally, in endothelial cells, some epigenetic
modifications occur during the formation of angiogenesis. Researchers have used some methylation inhibitors, histone deacetylase
inhibitors, or methylating agents (such as S-adenosylmethionine, SAM) against cancer and angiogenesis. Although they are effective to beat these diseases, each one results
in differentiation or changes in genome structure. We review epigenetically modified genes related with angiogenesis and metastasis
in cancer and endothelial cells, and suggest a new proposal. This hypothesis has discussed the importance of the usage of
DNA methylation inhibitors together with SAM to prevent tumor progression and genome instability or changes resulting in additional
diseases. 相似文献
90.