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排序方式: 共有71条查询结果,搜索用时 15 毫秒
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Ellise D. Liew Christopher P. Alderman 《International journal of clinical pharmacy》2014,36(2):253-255
Objective To report a case of syndrome of inappropriate anti-diuretic hormone (SIADH) secretion associated with desvenlafaxine. Case summary A 57-year-old female with hyponatraemia. Her medications included desvenlafaxine, and symptoms included nausea, anxiety and confusion. The serum sodium at this time was 120 mmol/L, serum osmolality was 263 mosmol/kg, urine osmolality 410 mosmol/kg and urine sodium 63 mmol/L, consistent with a diagnosis of SIADH. Desvenlafaxine was ceased and fluid restriction implemented. After 4 days the sodium increased to 128 mmol/L and fluid restriction was relaxed. During her further 3 weeks inpatient admission the serum sodium ranged from 134 to 137 mmol/L during treatment with mirtazapine. Discussion SIADH has been widely reported with a range of antidepressants. This case report suggests that desvenlafaxine might cause clinically significant hyponatremia. Conclusions Clinicians should be aware of the potential for antidepressants to cause hyponatremia, and take appropriate corrective action where necessary. 相似文献
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Jeannette T. Crenshaw Ellise D. Adams Richard E. Gilder Hannah G. Nolte 《Maternal & child nutrition》2021,17(4)
Women and their newborns are at risk of delayed or withheld skin‐to‐skin care (SSC) during a caesarean, which is about one‐third of births, worldwide. To date, no instrument exists to assess health professionals'' (HPs) beliefs, and potential barriers and strategies for implementing SSC during a cesarean. The study aims were to (1) develop an instrument, Health Professionals'' Beliefs about Skin‐to‐Skin Care During a Cesarean (SSCB), (2) establish its validity and reliability and (3) describe HPs'' beliefs about SSC during a caesarean. Quantitative and qualitative analyses were used to test the SSCB and describe HPs'' beliefs. SSCB analysis yielded a content validity of 0.83 and reliability of α = 0.9. We grouped all practice roles as either nurses or physicians. The mean rank score for nurses (n = 120, M = 90) was significantly higher (p = 0.001) than physicians (n = 46, M = 79). Despite this difference, scores for both roles reflected support for SSC. Participants identified hospital readiness to implement SSC and maintaining maternal and newborn safety as major issues. SSCB is a valid, reliable instrument to measure HPs'' beliefs about SSC during a caesarean birth. HPs can use the SSCB during quality improvement initiatives to improve access to immediate SSC for women who have a caesarean birth. Improved access can enhance breastfeeding outcomes and promote optimal maternal and child health. 相似文献
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Susanne Singer Cecilie Delphin Amdal Eva Hammerlid Iwona M. Tomaszewska Joaquim Castro Silva Hisham Mehanna Marcos Santos Johanna Inhestern Christine Brannan Noam Yarom Amy Fullerton Monica Pinto Juan I. Arraras Naomi Kiyota Pierluigi Bonomo Allen C. Sherman Ingo Baumann Razvan Galalae Loreto Fernandez Gonzalez Ourania Nicolatou‐Galitis Zeinab Abdel‐Hafeez Judith Raber‐Durlacher Claudia Schmalz Paola Zotti Andreas Boehm Dirk Hofmeister Sanja Krejovic Trivic Suat Loo Wei‐Chu Chie Kristin Bjordal Bente Brokstad Herlofson Vincent Grgoire Lisa Licitra 《Head & neck》2019,41(6):1725-1737
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Avidan MS Levy JH Scholz J Delphin E Rosseel PM Howie MB Gratz I Bush CR Skubas N Aldea GS Licina M Bonfiglio LJ Kajdasz DK Ott E Despotis GJ 《Anesthesiology》2005,102(2):276-284
BACKGROUND: The study evaluated the efficacy of recombinant human antithrombin (rhAT) for restoring heparin responsiveness in heparin resistant patients undergoing cardiac surgery. METHODS: This was a multicenter, randomized, double-blind, placebo-controlled study in heparin-resistant patients undergoing cardiac surgery with cardiopulmonary bypass. Heparin resistance was diagnosed when the activated clotting time was less than 480 s after 400 U/kg heparin. Fifty-four heparin-resistant patients were randomized. One cohort received 75 U/kg rhAT, and the other received normal saline. If the activated clotting time remained less than 480 s, this was considered treatment failure, and 2 units fresh frozen plasma was transfused. Patients were monitored for adverse events. RESULTS: Only 19% of patients in the rhAT group received fresh frozen plasma, compared with 81% of patients in the placebo group (P < 0.001). During their hospitalization, 48% of patients in the rhAT group received fresh frozen plasma, compared with 85% of patients in the placebo group (P = 0.009). Patients in the placebo group required higher heparin doses (P < 0.005) for anticoagulation. There was no increase in serious adverse events associated with rhAT. There was increased blood loss 12 h postoperatively (P = 0.05) with a trend toward increased 24-h bleeding in the rhAT group (P = 0.06). There was no difference between the groups in blood and platelet transfusions. CONCLUSION: Treatment with 75 U/kg rhAT is effective in restoring heparin responsiveness and promoting therapeutic anticoagulation in the majority of heparin-resistant patients. Treating heparin-resistant patients with rhAT may decrease the requirement for heparin and fresh frozen plasma. 相似文献
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