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111.
Candice Alexandra Grzelak Luciano Gastón Martelotto Nicholas David Sigglekow Bramilla Patkunanathan Katerina Ajami Sarah Ruth Calabro Benjamin James Dwyer Janina Elke Eleonore Tirnitz-Parker D. Neil Watkins Fiona Jane Warner Nicholas Adam Shackel Geoffrey William McCaughan 《Journal of hepatology》2014
112.
Rabia Shahswar Gernot Beutel Piroska Klement Alina Rehberg Razif Gabdoulline Christian Koenecke Dominik Markel Hendrik Eggers Matthias Eder Michael Stadler Lothar Hambach Steve Ehrlich Gudrun Göhring Brigitte Schlegelberger Elke Dammann Marlene Reuter Martin Wichmann Blerina Neziri Arnold Ganser Felicitas Thol Michael Heuser 《British journal of haematology》2020,188(3):e11-e15
113.
114.
Kirsten Maertens Sara De Schutter Tessa Braeckman Lesley Baerts Pierre Van Damme Ingrid De Meester Elke Leuridan 《Vaccine》2014
Vaccination during pregnancy results in an augmentation of disease specific maternal antibodies. Immunoglobulin G (IgG) is mainly transferred through the placenta during the third trimester of pregnancy, while secretory Immunoglobulin A (sIgA) is passed through breast milk. At birth, newborns are partially protected against infectious diseases by these antibodies. 相似文献
115.
Sabine Oertelt-Prigione Friederike Kendel Elke Lehmkuhl Roland Hetzer Vera Regitz-Zagrosek 《Zeitschrift fur Gesundheitswissenschaften》2014,22(3):219-226
Aim
Several large surveys have highlighted the inadequate risk factor control in populations at elevated cardiovascular risk. These populations would substantially benefit from risk reduction and could demonstrate increased awareness for risk factor control. Risk factor segregation by gender has been previously described, yet its analysis in the medical field frequently omits sociodemographic variables, which could act as potential confounders.Subject and methods
We analyzed risk factor prevalence in a population of 1,559 patients with severe coronary heart disease prior to a coronary bypass graft (CABG) surgery. Univariate correlations between risk factor type and frequency and gender were explored. Following, multivariable models were fitted to account for sociodemographic aspects associated with gender. Interaction terms were incorporated as fit. Lastly, the correlation between gender-specific risk factor profiles and their association with self-perceived health status was assessed.Results
Our study identified gender as the main segregating variable for risk factors after multiple adjustments and inclusion of interaction terms. Obesity and hypertension displayed a significant association with the female population (OR?=?1.598, p?=?0.047 and OR?=?3.737, p?=?0.006, respectively), while smoking and elevated alcohol consumption prevailed in males (OR?=?1.77, p?=?0.038 and OR?=?2.768, p?=?0.013, respectively). Additionally, gender-specific analysis of health perception according to risk factor loads revealed that male patients rate their health in overall better terms regardless of their risk profile.Conclusions
Our study confirmed the role of gender as the primary risk profile segregator after multiple adjustments for potential sociodemographic confounders, even in a population at elevated cardiovascular risk. Subjective health perception, which displayed marked gender differences, should be further investigated as a potential adherence and outcome modulator. 相似文献116.
Aisha Cortoos Elke De Valck Nathalie Pattyn Olivier Mairesse Raymond Cluydts 《International journal of psychophysiology》2014
According to the neurocognitive perspective on insomnia, conditioned arousal results in impairment of information processing, as such interfering with normal sleep processes. In the present study, evening event-related potentials N100 and P200 were evaluated to assess hyperarousal in patients with insomnia and controls. 13 patients (mean age = 40.8) with polysomnographically verified sleep disruptions and 11 good sleepers (mean age = 45.4) were included. An auditory oddball paradigm was administered the evening of the polysomnography. N100 and P200 mean amplitudes and peak latencies at Fz and Cz were analyzed as a measure of respectively general arousability and inhibition of information processing. Patients experiencing insomnia were characterized by decreased P200 amplitudes compared to good sleepers. No significant differences were found for N100 amplitudes and latencies of both ERP waves. 相似文献
117.
Alexander A. Bukreyev Kartik Chandran Olga Dolnik John M. Dye Hideki Ebihara Eric M. Leroy Elke Mühlberger Sergey V. Netesov Jean L. Patterson Janusz T. Paweska Erica Ollmann Saphire Sophie J. Smither Ayato Takada Jonathan S. Towner Viktor E. Volchkov Travis K. Warren Jens H. Kuhn 《Archives of virology》2014,159(4):821-830
The International Committee on Taxonomy of Viruses (ICTV) Filoviridae Study Group prepares proposals on the classification and nomenclature of filoviruses to reflect current knowledge or to correct disagreements with the International Code of Virus Classification and Nomenclature (ICVCN). In recent years, filovirus taxonomy has been corrected and updated, but parts of it remain controversial, and several topics remain to be debated. This article summarizes the decisions and discussion of the currently acting ICTV Filoviridae Study Group since its inauguration in January 2012. 相似文献
118.
Ellen G.H.M. van den Heuvel Natasja M. van Schoor Paul Lips Elke J.P. Magdeleyns Dorly J.H. Deeg Cees Vermeer Martin den Heijer 《Maturitas》2014
Objectives
Vitamin K plays a pivotal role in the synthesis of Matrix Gla protein (MGP), a calcification inhibitor in vascular tissue. Vascular calcification has become an important predictor of cardiovascular disease. The aim of the current study was to examine the potential association of circulating desphospho-carboxylated and -uncarboxylated MGP (dp-cMGP and dp-ucMGP), reflecting vitamin K status, with the incidence of cardiovascular events and disease (CVD) in older individuals.Study design
The study was conducted in 577 community-dwelling older men and women of the Longitudinal Aging Study Amsterdam (LASA), aged >55 year, who were free of cardiovascular disease at baseline. Multivariate Cox proportional hazards models were used to analyze the data.Main outcome measures
Incidence of CVD.Results
After a mean follow-up of 5.6 ± 1.2 year, we identified 40 incident cases of CVD. After adjustment for classical confounders and vitamin D status, we observed a more than 2-fold significantly higher risk of CVD for the highest tertile of dp-ucMGP with a HR of 2.69 (95% CI, 1.09–6.62) as compared with the lowest tertile. Plasma dp-cMGP was not associated with the risk of CVD.Conclusions
Vitamin K insufficiency, as assessed by high plasma dp-ucMGP concentrations is associated with an increased risk for cardiovascular disease independent of classical risk factors and vitamin D status. Larger epidemiological studies on dp-ucMGP and CVD incidence are needed followed by clinical trials to test whether vitamin K-rich diets will lead to a decreased risk for cardiovascular events. 相似文献119.
120.
Franco M. Buonaguro Maria Lina Tornesello Elke Beth-Giraldo Angelo Hatzakis Nancy Mueller Robert Downing Bennon Biryamwaho Silvester D. R. Sempala Gaetano Giraldo 《International journal of cancer. Journal international du cancer》1996,65(1):25-28
The identification of Kaposi's sarcoma (KS) clusters in subequatorial Africa (endemic KS, AKS) and the high frequency of KS in sexually transmitted AIDS (epidemic KS, EKS), have previously suggested a role for infectious agents in the etiopathogenesis of KS. The recent identification of herpesvirus (HHV)-like DNA sequences in one case of EKS and their detection in >90% of all tested EKS, prompted us to determine the prevalence of these viral sequences in all types of KS, such as AKS, EKS, classic KS (CKS) and iatrogenic KS (IKS). The presence of herpesvirus (HHV)-like DNA sequences has been examined in 61 KS skin tumors obtained from Greece, Italy, USA, Uganda and Kenya. All KS types (100%) were positive by polymerase chain reaction (PCR) and Southern-blot analysis, while 5 out of 6 (83%) and 4 out of 7 (57%) uninvolved autologous skin biopsies from AKS and CKS patients, respectively, were positive for HHV-like sequences. All samples from non-KS patients were negative, i.e. 17 human biopsies from healthy individuals or patients affected by other pathologies, 5 human cell lines and 15 peripheral blood mononuclear cells (PBMC) from HIV-positive subjects. These results suggest that HHV-like sequences play a major role in the pathogenesis of this neoplasm. © 1996 Wiley-Liss, Inc. 相似文献