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Elizabeth P. Eustis-Turf Joyce A. Benjamins Maurice J. Lefford 《Journal of neuroimmunology》1986,10(4):313-330
Sera from 43 leprosy patients were tested for antibodies that bound to normal human nerve. Thirty-eight percent showed positive staining as demonstrated by indirect immunofluorescence. Only 1 out of 30 control sera tested displayed similar staining. Western blots of myelin and neural intermediate filament (IF) proteins were tested with patient sera. Two of the anti-neural antibody (ANeAb)-positive leprosy sera bound to the P0 protein of PNS myelin. All 17 ANeAb-positive leprosy sera displayed 2 or more bands in the molecular weight range of Mr 45 000-55 000, when tested against IF proteins. One explanation for these findings is that leprosy patients produce antibodies to intermediate filament (IF) proteins released subsequent to the bacterial invasion of the peripheral nerves. The importance of these autoantibodies in the pathogenesis of leprosy is discussed. 相似文献
85.
D. Le Elizabeth Eric R. Powers Jian-Ping Bin Howard Leong-Poi N. Craig Goodman Sanjiv Kaul 《Journal of nuclear cardiology》2007,14(2):207-214
Background The mechanism by which transmyocardial revascularization (TMR) offers clinical benefit is controversial. We hypothesized that
TMR ameliorates ischemia by reversing paradoxical catecholamine-induced vasoconstriction.
Methods and Results Chronic ischemic cardiomyopathy was created in 11 dogs by placing ameroid constrictors on the proximal coronary arteries and
their major branches. Six weeks later, 35 channels were created percutaneously in the left circumflex artery region, with
the left anterior descending artery region serving as control. At rest, wall thickening and myocardial blood flow did not
change in the treated region, whereas they deteriorated in the control bed. Contractile and myocardial blood flow reserve
increased in the treated region but deteriorated in the control region. There was diminished iodine 123 metaiodobenzylguanidine
uptake and a significant reduction in noradrenergic nerves in the treated region compared with the control region, with a
corresponding reduction in tissue tyrosine hydroxylase activity.
Conclusions We conclude that the absence of a catecholamine-induced reduction in MBF reserve and contractile reserve in the TMR-treated
region with associated evidence of neuronal injury indicates that the relief of exercise-induced ischemia after TMR most likely
results from reversal of paradoxical catecholamine-induced vasoconstriction. These findings may have implications in selecting
patients who would benefit from TMR.
Supported in part by grants from the National Institutes of Health (R01-HL66034 and K-08-HL074290-01). Bethesda. Md. The radio-labeled
microspheres were provided by DuPont Pharmaceuticals, North Billerica. Mass, and the ultrasound equipment was supplied by
Philips. Andover, Mass. Dr Leong-Poi was the recipient of a Fellowship Training Grant from the Canadian Institute of Health
Research and the Heart and Stroke Foundation of Canada. 相似文献
86.
The purpose of this pilot study was to observe both relaxed and deep breathing patterns in a convenience sample to determine the incidence of normal versus faulty patterns of respiration. These observations were then combined with respondent answers to a survey on pain history to determine if there is any correlation between faulty breathing and musculo-skeletal pain patterns. If such a correlation can be made, then we propose that clinicians working with chronic pain patients may have improved outcomes if they address and correct faulty breathing patterns. Based on this study, it is suggested to include the evaluation and treatment of faulty respiration in the rehabilitation of chronic musculo-skeletal conditions, most notably cervical pain. 相似文献
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88.
Judith D. DePue Elizabeth L. McQuaid Daphne Koinis-Mitchell Christopher Camillo Anthony Alario Robert B. Klein 《The Journal of asthma》2007,44(6):449-453
Over 3 years, 972 families participated in an after-school asthma program at their child's school. Parents and children attended concurrent 21/2 -hour workshops. Parents were 74% Latino; 45% non-English speaking, with 77% of children on Medicaid. Asthma symptoms were significantly reduced, from multiple times per week to less than once per week on average. Oral steroid use decreased to one third of baseline use. Hospital days decreased from 11% to 2%; emergency visits decreased 35% to 4%; and school days missed decreased 48% to 20%. This program has now become sustainable with both private and Medicaid insurance coverage. 相似文献
89.
B Denise Raynor Elizabeth A Bonney Kyung T Jang Wendy Coto Meera S Garcia 《Hypertension in pregnancy》2004,23(2):129-134
Several parallels exist between preeclampsia and atherosclerosis. Both are multifactorial diseases that share risk factors such as obesity, insulin resistance, lipid abnormalities, and elevated serum homocysteine. There are also similarities in the biochemical changes seen in both diseases, including elevated serum triglycerides, decreased HDL cholesterol and enhanced formation of small, dense LDL particles as well as vascular atherosclerotic lesions. Chronic infection with Chlamydia pneumoniae has been linked to coronary artery disease. This study evaluated a possible link between the incidence of preeclampsia and infection with C. pneumoniae by examining the rate of seropositivity in 81 women with preeclampsia, and 206 women with normal pregnancies. Although our data confirmed well-known risk factors for preeclampsia such as obesity, diabetes, and hypertension, we found no difference in the rate of seropositivity between preeclampsia and normal pregnancy. On the contrary, the presence of chlamydial antibodies was lower in preeclampsia. Multiparous women with preeclampsia showed a significantly lower rate of seropositivity than multiparous normal women and nulliparous preeclamptics. In addition, women with a history of preeclampsia who developed preeclampsia in the current pregnancy also had a significantly lower rate of seropositivity. 相似文献
90.
Elizabeth B Haagsma Ingrid I Van Gameren Johan Bijzet Marcel D Posthumus Bouke P C Hazenberg 《Amyloid》2007,14(3):221-226
To estimate the evolution of amyloid in tissue, we studied abdominal fat aspirates of cases with familial amyloidotic polyneuropathy (FAP) longitudinally at regular intervals between 1994 and 2006. In 22 cases (13 carriers and nine patients) not yet transplanted median follow-up was 3.3 years (range 0.4-11.3). We found a significant increase in the amyloid grade of fat tissue from 2+ to 4+ and from 0 to 4+ in two of three subjects with follow-ups of >7 years, after 7 and 11 years, respectively. All other subjects remained negative or did not show a significant change. In 11 liver transplant patients, follow-up with fat aspirate was available with a median duration of 3.1 years (range 1.0-10.1). A comparison was made with cardiac amyloid as judged by the cardiac septum diameter and the serum NT-ProBNP (N-terminal pro-B-type natriuretic peptide) level. No stable increase of amyloid in fat was seen in any patient. A stable decrease of amyloid grade was seen in one patient 5 years after transplantation. In contrast, the cardiac septum diameter increased >or=4 mm in six of the 11 transplant patients. Our study shows the diagnostic utility of a regularly repeated fat aspirate in carriers at risk for the development of ATTR amyloidosis. Evolution of amyloid deposition in fat tissue is very gradual. After liver transplantation, amyloid deposition in fat tissue seems to stabilize and may even decrease in the long term, whereas amyloid deposition in cardiac tissue appears to be progressive. 相似文献