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991.
992.
993.
Lafdil F Chobert MN Couchie D Brouillet A Zafrani ES Mavier P Laperche Y 《Hepatology (Baltimore, Md.)》2006,44(1):228-239
The protein product of the growth arrest-specific gene 6 (Gas6) is a secreted ligand for tyrosine kinase receptors, among which Axl is the most widely distributed and displays the highest affinity for Gas6. The Gas6/Axl signaling pathway has been increasingly implicated in growth and survival processes occurring during development and tissue repair. In liver, after an acute or chronic injury, repair involves macrophages and hepatic stellate cells (HSC) activated into myofibroblastic cells (HSC/MFB), which produce cytokines and matrix proteins. We investigated the expression and the role of Gas6 and its receptor Axl in liver repair. Three days after CCl4-induced liver injury in the rat, we detected the expression of Gas6 in ED1-positive macrophages as well as in desmin-positive HSC, which accumulated in injured areas. Axl, the high-affinity receptor for Gas6, was detected in macrophages, HSC, and HSC/MFB. In vitro, expression of gamma-carboxylated Gas6 was strongly induced in HSC along with their transformation into myofibroblasts, and it exerted an anti-apoptotic effect on both HSC and HSC/MFB mediated by the Axl/PI3-kinase/Akt pathway. In conclusion, Gas6 is a survival factor for these cells and we suggest that Gas6, secreted by macrophages and HSC/MFB in vivo after liver injury, promotes HSC and HSC/MFB survival and might support transient HSC/MFB accumulation during liver healing. 相似文献
994.
995.
Hlne Duplan Jean Claude Bs Mathieu Tafani Brigitte Sallerin Jacqueline Sagen Elie Ohayon Yves Lazorthes Jean Tkaczuk 《Experimental neurology》2000,163(2):331
Adrenal medullary (AM) tissue transplantation into the central nervous system has been reported as a potential source of opioid peptides and catecholamines, which have analgesic effects useful in the control of chronic pain. Clinical trials, involving allogeneic graft of whole tissue explants into the subarachnoid space of the lumbar spinal cord, have already been reported. The aim of the present study was to determine whether adhesion and function of AM explants were related in some extent and how this relationship could account for improvement of AM tissue in terms of analgesic activity before grafting. Our experiments demonstrated a significant correlation between the adherent state of AM organoids during culture and a sustained secretion of Met-enkephalin and catecholamines by chromaffin cells (CC). These findings suggest that optimal culture condition for AM organoid adhesion can be defined for maintenance of tissue, prior to transplantation. Using immunocytochemistry, flow cytometry, and ELISA assays we showed that different cell adhesion molecules (CAMs) and extracellular matrix ECM proteins were expressed and released by AM cells during culture. Adherent AM organoids expressed increased levels of specific neural CAMs (NCAM and HNK-1 epitope) and integrin chains (β1, α1, α2, α4, α5) and deposited markedly higher levels of fibronectin, but also laminin and collagen IV. Those molecules and probably adhesion processes they control might be involved in the maintenance of the CC-secreting neuroendocrine phenotype through cellular signaling pathways. 相似文献
996.
Fousseyni S. Touré Elie Mavoungou Jérôme Mezui Me Ndong Paul Tshipamba & Philippe Deloron 《Tropical medicine & international health : TM & IH》2001,6(10):767-769
We have designed primers to the conserved region of the erythrocyte binding antigen (EBA)-175 gene which amplify specifically the two alleles by polymerase chain reaction (PCR) and by nested PCR. This approach provides a specific, sensitive and rapid method for genotype determination in a large number of Plasmodium falciparum field isolates. 相似文献
997.
Elie A Akl Khalil El-Asmar Nancy Maroun Salim M Adib Beatrice Khater-Menassa 《BMC health services research》2008,8(1):195
Background
A significant number of Lebanese medical graduates have emigrated from Lebanon. The objective of this study was to evaluate the hypothesis that the repatriation of Lebanese physicians educated abroad has contributed to the international emigration of recent Lebanese medical graduates. 相似文献998.
Ccile Watier‐Launey Anne Buronfosse Elie Saliba Philippe Bertrand Marie‐Josphe Ployet 《The Laryngoscope》2000,110(2):328-328
Objectives: To determine which factors contribute to early complications when intubated children show macroscopic lesions at extubation. Study Design: Retrospective review of 96 consecutive medical records of children aged 1 day to 15 years. Patients were divided into three groups depending on the extent of the subsequent treatment required: medical, reintubation, and surgical. Methods: Age, sex, clinical history, and macroscopic features of the lesions were collected and data were compared in each group. Results: Underlying noninfectious respiratory diseases and young age were found to be risk factors for higher incidence of complications, but not prolonged or multiple intubations. Edema, especially in the glottic area, was a risk factor for surgical treatment. Multiple lesions were risk factors for reintubation. Conclusions: History of intubation, its cause, and lesions discovered at extubation can provide the basis for definition of an “at risk” profile for intubated children. 相似文献
999.
1000.
Fanny Buyens Odile Jolivet Alain De Cesare Jacques Bittoun Alain Herment Jean-Pierre Tasu Elie Mousseaux 《Magnetic resonance in medicine》2005,53(4):877-884
Measurements of pressure variations within the cardiac chambers could provide important information for clinical assessments of cardiovascular function. In this work an MRI method for evaluating spatial distributions of intracardiac relative pressure is presented. We first calculated pressure gradients from MR maps of blood acceleration by applying the NS equation. We then used an original algorithm to compute pressure distribution in a region of interest (ROI) by minimizing the pressure gradient curl so that the result in a given pixel is independent of the integration path. The method was assessed in five healthy volunteers by means of MR 2D maps of the blood acceleration in the left ventricle (LV) during ejection and filling phases. The pressure variations calculated from acceleration mapping fit the known physiological variations better than those based on velocity maps acquired in the same volunteers. Furthermore, the optimization algorithm presented here produced the same results as iterative algorithms proposed by other authors, but in much less time and without requiring adjustable parameters or boundary conditions. 相似文献