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21.
Elaheh Rashidbeygi Mohammad Hossein Rahimi Mehdi Mollahosseini Mir Saeed Yekaninejad Hossein Imani Zhila Maghbooli Khadijeh Mirzaei 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(6):985-990
Background
Recent studies have shown that Vitamin D deficiency is very common globally. Vitamin D deficiency is associated with lipid metabolism. A relationship between vitamin D levels and waist circumference (WC) has been observed. The purpose of this study is to evaluate the relationship between vitamin D status and metabolic dyslipidemia and the hypertriglyceridemic waist phenotype.Methods
This cross-sectional study was conducted on 265 healthy Tehran adults. Hypertriglyceridemic waist phenotype (HTGWP) was described as serum triacylglycerol concentrations >150?mg/dL and concurrent WC?>?88?cm (women) and >102?cm (men). Dyslipidemia was defined as: 1) TG level of >150?mg/dL 2) HDL?>?40?mg/dL for men or >50?mg/dL for women, as has been previously described.Results
Current study’s results demonstrated that HTGWP was significantly associated with weight, age, WC, hip, fat percent, TG, lipid profile, ALT and BMI. We found 77% reduction in the chances of developing metabolic dyslipidemia in suficient satus of vitamin D in compare to deficiency, although the significancy was mariginal, OR: 0.33, 95% CI of 0.09 to 1.21, P?=?0.09. However, our results revealed that vitamin D deficiency, compared with normal status, can increase the risk of phenotype 1 (high TG/high WC); OR: 3.86 and 95% CI from 0.86 to 0.99, p for trend?=?0.05.Conclusions
Significant associations were found between vitamin D status and HTGWP. In addition, there was a relationship between vitamin D and lipid profiles. There is a direct correlation between TG and waist circumference in insulin resistance in healthy Tehran adults. 相似文献22.
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Yunes PANAHI Bahram PISHGOO Hamid R. JALALIAN Elaheh MOHAMMADI Hamid R. TAGHIPOUR Amirhossein SAHEBKAR Ehsan ABOLHASANI 《Nutrition & Dietetics》2012,69(1):13-19
Aim: Chlorella vulgaris is a unicellular green microalga with several pharmacological activities including anti‐hyperlipidemic effects. In spite of interesting preclinical findings, the clinical efficacy of C. vulgaris in dyslipidemia—whether alone or in combination with statins—has not been clarified. The present study aimed to investigate the impact of supplementation with C. vulgaris as an adjunctive therapy to atorvastatin in dyslipidemic subjects. Methods: In a randomised, open‐label clinical trial, 100 dyslipidemic subjects were randomly assigned to: (i) Chlorella group (n = 50, dropouts = 24), receiving C. vulgaris (600 mg/day) + atorvastatin (20 mg/day) for 8 weeks; or (ii) atorvastatin group (n = 50, dropouts = 13), receiving only atorvastatin (20 mg/day) for 8 weeks. Lipid profile and biomarkers of muscular, hepatic and renal injury were determined at baseline and at the end of the trial. Results: There were significant reductions in serum total cholesterol (P < 0.001), low‐density lipoprotein cholesterol (P < 0.001) and triglycerides (P= 0.006 in Chlorella and P= 0.004 in atorvastatin group) in both groups. No significant change in serum high‐density lipoprotein cholesterol levels was observed in any of the groups. Serum aspartate aminotransferase levels were raised in both Chlorella (P= 0.034) and atorvastatin (P= 0.002) groups, whereas alkaline phosphatase was only elevated in the Chlorella group (P= 0.028). In comparison with baseline values, no significant change was observed in serum levels of alanine aminotransferase, creatine phosphokinase, creatinine, blood urea nitrogen and fasting blood sugar. Conclusion: Based on the results, addition of C. vulgaris to atorvastatin therapy for 8 weeks does not appear to be associated with an improved control of serum lipid profile. 相似文献
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Reza Shabanian Abdolrazagh Kiani Elaheh Malakan Rad Hosein Eslamiyeh 《Pediatric cardiology》2010,31(2):274-276
This report describes a 3-month-old boy with isolated left ventricular noncompaction admitted to a medical facility due to heart failure and dysrhythmia. His electrocardiogram showed a short PR interval and a normal QRS complex after abortion of supraventricular tachycardia in favor of Lown-Ganong-Levine syndrome or enhanced atrioventricular nodal conduction. 相似文献
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Khanmohammadi M Mobedi E Garmarudi AB Mobedi H Kargosha K 《Pharmaceutical development and technology》2007,12(6):573-580
A novel analytical procedure has been developed for quantitative determination of levodopa and carbidopa in aqueous binary solutions acidified by HCl and without any other sample pretreatment. The method is based partially on least squares treatment of data obtained by attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectrometry in 1211-1315 cm(-1) and 1488-1550 cm(-1) spectral regions. The simple, rapid, and accurate proposed method was applied to determine levodopa and carbidopa in Levodopa-C tablets. The statistical parameters, such as R2, RSD, SEE, SECV, LOD, and recovery were evaluated. Number of factors, scans, and resolution were optimized. In this method R2 and RSD for levodopa and carbidopa were (0.9965, 1.209) and (0.9537, 0.813), respectively. 相似文献
28.
Shiroodi MK Shafiei B Baharfard N Gheidari ME Nazari B Pirayesh E Kiasat A Hoseinzadeh S Hashemi A Akbarzadeh MA Javadi H Nabipour I Assadi M 《The international journal of cardiovascular imaging》2012,28(1):211-217
Rapid technetium-99 m methoxyisobutylisonitrile (99 mTc-MIBI) washout has been shown to occur in impaired myocardia. This study is based on the hypothesis that scintigraphy can be applied to calculate the myocardial 99 mTc-MIBI washout rate (WR) to diagnose and evaluate heart failure severity and other left ventricular functional parameters specifically in idiopathic dilated cardiomyopathy (IDCM) patients. Patients with IDCMP (n = 17; 52.65 ± 11.47 years) and normal subjects (n = 6; 49.67 ± 10.15 years) were intravenously administered 99 mTc-hexakis-2-methoxyisobutylisonitrile (99 mTc-MIBI). Next, early and delayed planar data were acquired (at 3.5-h intervals), and electrocardiogram (ECG)-gated myocardial perfusion single photon emission computed tomography (SPECT) was performed. The 99 mTc-MIBI WR was calculated using early and delayed planar images. Left ventricular functional parameters were also analyzed using quantitative gated SPECT (QGS) data. In target group, myocardial WRs (29.13 ± 6.68%) were significantly higher than those of control subjects (14.17 ± 3.31%; P < 0.001). The 99 mTc-MIBI WR increased with the increasing severity of the NYHA functional class (23.16 ± 1.72% for class I, 30.25 ± 0.95% for class II, 32.60 ± 6.73% for class III, and 37.50 ± 7.77% for class IV; P = 0.02). The WR was positively correlated with the end-diastolic volume (EDV) index (r (2) = 0.216; β = 0.464; P = 0.02 [ml/m(2)], the end-systolic volume (ESV) index (r (2) = 0.234; β = 0.484; P = 0.01 [ml/m(2)]), the summed motion score (SMS) (r (2) = 0.544; β = 0.738; P = 0.00), and the summed thickening score (STS) (r (2) = 0.656; β = 0.810; P = 0.00); it was negatively correlated with the left ventricular ejection fraction (LVEF) (r (2) = 0.679; β = -0.824; P = 0.00). It can be concluded that 99 mTc-MIBI scintigraphy might be a valuable molecular imaging tool for the diagnosis and evaluation of myocardial damage or dysfunction severity. 相似文献
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Factors Affecting Long-Survival of Patients with Esophageal Cancer Using Non-Mixture Cure Fraction Model 下载免费PDF全文
Elaheh ZareanMehdi Azizmohammad LoohaPayam AminiMahmood MahmoudiTara Azimi 《Asian Pacific journal of cancer prevention》2018,19(6):1677-1683
Objective: Esophageal cancer (EC) is one of the gastrointestinal malignancies with a very high morbidity andmortality rate due to poor prognosis. This study aims to assess the effects of risk factors on survival and cure fraction ofpatients with EC in a population of Iranian patients using a non-mixture cure fraction model. Methods: This retrospectivecohort study was conducted on 127 patients with EC who were diagnosed during 2009-2010 and were followedup for 5 years in East-Azarbaijan, Iran. Stepwise selection and non-mixture cure fraction model were used to findthe risk factors of EC survival patients. Results: The mean (±standard deviation) diagnosis age of the EC was66.92(±11.95). One, three and five-year survival probabilities were 0.44 (95% confidence interval (CI): 0.36-0.54),0.2 (95% CI: 0.14-0.28) and 0.13 (95% CI: 0.08-0.2) respectively. Female sex (Estimate=-0.99; 95% confidence interval(CI): -1.41,-0.58; p-value<0.001), low level socioeconomic status (Estimate=0.39; 95%CI: 0.12,0.66; p-value=0.043),the group who did not do esophagectomy surgery (Estimate=0.58; 95%CI: 0.17,0.99; p-value=0.005) and unmarriedgroup (Estimate=0.58; 95%CI: 0.11-1.05; p-value=0.015) were found as the significant predictor of survival andcure fraction of the EC patients. Population cure rate was 0.11 (95%CI: 0.07-0.19) and Cure fraction was estimated5.11 percent. Conclusion: This study found gender, socioeconomic status, Esophagectomy surgery and marital statusas the potential risk factors for survival and cure fraction of Iranian EC patients. Moreover, non- mixture cure fractionprovides more accurate and more reliable insight into long-term advantages of EC therapy compared to standard classicsurvival analysis alternatives. 相似文献