全文获取类型
收费全文 | 2916篇 |
免费 | 170篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 62篇 |
儿科学 | 53篇 |
妇产科学 | 133篇 |
基础医学 | 253篇 |
口腔科学 | 103篇 |
临床医学 | 221篇 |
内科学 | 807篇 |
皮肤病学 | 58篇 |
神经病学 | 304篇 |
特种医学 | 89篇 |
外科学 | 416篇 |
综合类 | 8篇 |
预防医学 | 108篇 |
眼科学 | 102篇 |
药学 | 161篇 |
中国医学 | 1篇 |
肿瘤学 | 226篇 |
出版年
2024年 | 7篇 |
2023年 | 51篇 |
2022年 | 93篇 |
2021年 | 148篇 |
2020年 | 79篇 |
2019年 | 107篇 |
2018年 | 125篇 |
2017年 | 88篇 |
2016年 | 90篇 |
2015年 | 94篇 |
2014年 | 131篇 |
2013年 | 163篇 |
2012年 | 227篇 |
2011年 | 234篇 |
2010年 | 117篇 |
2009年 | 123篇 |
2008年 | 167篇 |
2007年 | 143篇 |
2006年 | 155篇 |
2005年 | 133篇 |
2004年 | 124篇 |
2003年 | 110篇 |
2002年 | 109篇 |
2001年 | 26篇 |
2000年 | 26篇 |
1999年 | 25篇 |
1998年 | 9篇 |
1997年 | 15篇 |
1996年 | 16篇 |
1995年 | 16篇 |
1994年 | 16篇 |
1993年 | 12篇 |
1992年 | 18篇 |
1991年 | 7篇 |
1990年 | 10篇 |
1989年 | 6篇 |
1988年 | 10篇 |
1987年 | 5篇 |
1986年 | 7篇 |
1985年 | 12篇 |
1984年 | 10篇 |
1983年 | 6篇 |
1982年 | 5篇 |
1981年 | 3篇 |
1980年 | 3篇 |
1976年 | 4篇 |
1974年 | 3篇 |
1969年 | 2篇 |
1968年 | 3篇 |
1966年 | 2篇 |
排序方式: 共有3105条查询结果,搜索用时 31 毫秒
71.
72.
73.
Ivano Bonadei MD Enrico Vizzardi MD Antonio D'Aloia MD Edoardo Sciatti MD Riccardo Raddino MD Marco Metra MD 《Journal of clinical hypertension (Greenwich, Conn.)》2014,16(3):202-206
Arterial stiffness and endothelial dysfunction are important determinants of cardiovascular events in patients with arterial hypertension. There are few data regarding the role of aliskiren on the central hemodynamics and endothelial function in patients with uncontrolled arterial hypertension. The aim of this study was to assess the addition of aliskiren to other antihypertensive drug treatment for arterial stiffness and endothelial function. Thirty uncontrolled hypertensive patients (mean age, 60.4±12.2 years), without any other cardiovascular risk factors, were enrolled. Augmentation index (AIx) and carotid‐femoral pulse wave velocity (cfPWV) by applanation tonometry and reactive hyperemia peripheral arterial tonometry (RH PAT) index using peripheral arterious tonometry at baseline and after 6 months of aliskiren titrated to 300 mg once a day was evaluated. The addition of aliskiren had no effect on values of central AIx (33.26±10.74% vs 28.86±10.74%; P=.36) but did significantly improve values of cfPWV (9.36±2.65 m/s vs 8.72±2.48 m/s; P=.04) and RH PAT index (1.64±0.57 vs 1.75±0.45; P=.05). In addition to improving systolic and diastolic blood pressure, the addition of aliskiren to concomitant antihypertensive drugs in uncontrolled hypertensive patients may be effective in improving aortic stiffness and endothelial function. These results encourage further studies to evaluate the use of aliskiren for cardiovascular prevention. 相似文献
74.
75.
76.
Edoardo Troncone Alessandro Fugazza Annalisa Cappello Giovanna Del Vecchio Blanco Giovanni Monteleone Alessandro Repici Anthony Yuen Bun Teoh rea Anderloni 《World journal of gastroenterology : WJG》2020,26(16):1847-1860
Malignant gastric outlet obstruction(MGOO) is a clinical condition characterized by the mechanical obstruction of the pylorus or the duodenum due to tumor compression/infiltration, with consequent reduction or impossibility of an adequate oral intake. MGOO is mainly secondary to advanced pancreatic or gastric cancers, and significantly impacts on patients' survival and quality of life.Patients suffering from this condition often present with intractable vomiting and severe malnutrition, which further compromise therapeutic chances. Currently,palliative strategies are based primarily on surgical gastrojejunostomy and endoscopic enteral stenting with self-expanding metal stents. Several studies have shown that surgical approach has the advantage of a more durable relief of symptoms and the need of fewer re-interventions, at the cost of higher procedure-related risks and longer hospital stay. On the other hand, enteral stenting provides rapid clinical improvement, but have the limit of higher stent dysfunction rate due to tumor ingrowth and a subsequent need of frequent reinterventions. Recently, a third way has come from interventional endoscopic ultrasound, through the development of endoscopic ultrasound-guided gastroenterostomy technique with lumen-apposing metal stent. This new technique may ideally encompass the minimal invasiveness of an endoscopic procedure and the long-lasting effect of the surgical gastrojejunostomy, and brought encouraging results so far, even if prospective comparative trial are still lacking. In this Review, we described technical aspects and clinical outcomes of the above-cited therapeutic approaches, and discussed the open questions about the current management of MGOO. 相似文献
77.
Chiara De Cassan Edoardo Savarino Piero Marson Tiziana Tison Giorgia Hatem Giacomo Carlo Sturniolo Renata D’Incà 《World journal of gastroenterology : WJG》2014,20(45):17155-17162
AIM:To evaluate whether the effectiveness of Granulomonocyto apheresis(GMA),a technique that consists of the extracorporeal removal of granulocytes and monocytes from the peripheral blood,might vary according to the severity of ulcerative colitis(UC)in patients with mild to moderate-severe disease UC activity.METHODS:We retrospectively reviewed prospectively collected data of patients undergoing GMA at our inflammatory bowel disease centre who had at least a 6 mo of follow-up.The demographics,clinical and laboratory data were extracted from the patients’charts and electronic records.The severity of UC was scored according to the Modified Truelove Witts Severity Index(MTWSI).A clinical response was defined as a decrease from baseline of≥2 points or a value of MTWSI≤2 points.RESULTS:A total of 41(24 males/17 females;meanage 47 years)patients were included in the study.After GMA cycle completion,21/28(75%)of mild UC patients showed a clinical response compared with 7/13(54%)of patients with moderate to severe disease(P=0.27).At 6-mo,14/28(50%)of the mild UC patients maintained a clinical response compared with 2/13(15%)of the patients with moderate to severe disease(P=0.04).After the GMA cycle completion and during the 6-mo follow up period,13/16(81%)and 9/16(56%)of mild UC patients with intolerance,resistance and contraindications to immunosuppressants and/or biologics showed a clinical response compared with 2/6(33%)and 0/6(0%)of patients with moderate to severe disease activity with these characteristics(P=0.05and P=0.04,respectively).CONCLUSION:Patients with mild UC benefit from GMA more than patients with moderate to severe disease in the short-term period.GMA should be considered a valid therapeutic option in cases of contraindications to immunosuppressants,corticosteroids and/or biologics. 相似文献
78.
79.
80.