全文获取类型
收费全文 | 3070篇 |
免费 | 162篇 |
国内免费 | 12篇 |
专业分类
耳鼻咽喉 | 46篇 |
儿科学 | 166篇 |
妇产科学 | 175篇 |
基础医学 | 351篇 |
口腔科学 | 128篇 |
临床医学 | 200篇 |
内科学 | 736篇 |
皮肤病学 | 54篇 |
神经病学 | 273篇 |
特种医学 | 74篇 |
外科学 | 411篇 |
综合类 | 27篇 |
预防医学 | 204篇 |
眼科学 | 123篇 |
药学 | 170篇 |
中国医学 | 2篇 |
肿瘤学 | 104篇 |
出版年
2023年 | 33篇 |
2022年 | 33篇 |
2021年 | 74篇 |
2020年 | 58篇 |
2019年 | 76篇 |
2018年 | 132篇 |
2017年 | 95篇 |
2016年 | 116篇 |
2015年 | 103篇 |
2014年 | 128篇 |
2013年 | 194篇 |
2012年 | 266篇 |
2011年 | 260篇 |
2010年 | 144篇 |
2009年 | 105篇 |
2008年 | 197篇 |
2007年 | 186篇 |
2006年 | 193篇 |
2005年 | 185篇 |
2004年 | 128篇 |
2003年 | 124篇 |
2002年 | 107篇 |
2001年 | 47篇 |
2000年 | 50篇 |
1999年 | 52篇 |
1998年 | 4篇 |
1997年 | 3篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1994年 | 2篇 |
1993年 | 5篇 |
1992年 | 17篇 |
1991年 | 17篇 |
1990年 | 18篇 |
1989年 | 10篇 |
1988年 | 8篇 |
1987年 | 13篇 |
1986年 | 12篇 |
1985年 | 7篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1977年 | 3篇 |
1975年 | 3篇 |
1973年 | 4篇 |
1971年 | 2篇 |
1968年 | 3篇 |
1967年 | 1篇 |
1966年 | 3篇 |
1965年 | 1篇 |
1962年 | 1篇 |
排序方式: 共有3244条查询结果,搜索用时 31 毫秒
991.
992.
993.
Detection and comparison of neuraminidase activities in human and bovine group B streptococci
下载免费PDF全文
![点击此处可从《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Ismail Hakki Ekin Kemal Gurturk Ziya Ilhan Suat Ekin Ayse Ebru Borum Cigdem Arabaci Abdullah Yesilova 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2016,124(12):1093-1098
Human and bovine group B streptococcus (GBS) isolates were serotyped and amounts of released N‐acetylneuraminic acid from N‐acetylneuraminyl‐lactose by extracellular neuraminidase were colorimetrically assessed. According to serotyping by co‐agglutination method, 30 of bovine GBS and 43 of human GBS could be serotyped (ST) by monospecific antisera coated with protein A. The remaining GBS strains were designated as nontypeable (NT). The released N‐acetylneuraminic acid was determined in 90.9% of bovine GBS and 47.1% of human GBS isolates. The differences between the total bovine and human GBS isolates were statistically significant (p < 0.001). In comparison with detected N‐acetylneuraminic acid level in bovine and human groups, significant decrease was observed in the bovine NT group according to increased human NT (p < 0.01) and bovine ST groups (p < 0.01). However, N‐acetylneuraminic acid level in bovine ST and bovine total groups significantly (p < 0.001) increased with respect to the human ST group and human total group. Neuraminidase activity was detected more frequently in bovine GBS isolates. Considerable differentiations were observed between typeable and nontypeable isolates. 相似文献
994.
995.
996.
Deborah L. Jones Mar Lucas Inés Arístegui Alejandra Bordato Graciela Fernandez-Cabanillas Virginia Zalazar 《AIDS care》2016,28(10):1287-1295
Challenging HIV-infected patients, those neither adherent nor actively engaged in care, represent an important opportunity for intervention if the HIV epidemic is to be contained. This pilot study assessed the feasibility and acceptability of an adapted patient adherence intervention and a motivational interview-based provider intervention in urban Buenos Aires, Argentina, in order to optimize health benefits in challenging HIV-infected patients. To maximize implementation and uptake of both strategies, interventions were adapted to the local setting. Qualitative data and a short quantitative assessment from patients, staff, fellows, residents and physicians (n?=?84) were examined to establish the feasibility and acceptability of offering patient and provider evidence-based interventions in both public and private health-care settings. Results identified key themes on provision of information, use of specialized communication techniques and group support in the utilization of the interventions. Both providers (n?=?12) and patients (n?=?120) endorsed the acceptability and value of the interventions, and the feasibility of their delivery. Findings support the use of both intervention modalities with challenging patients in diverse urban health-care settings. 相似文献
997.
Ebru Gok Oguz Hadim Akoglu Gulay Ulusal Okyay Ozlem Yayar Guner Karaveli Gursoy Mehmet Buyukbakkal 《Renal failure》2016,38(7):1059-1066
Objective: Depression and anxiety are prevalent affective disorders in peritoneal dialysis (PD) patients. Recent research has proposed a potential role of apelinergic system in pathogenesis of depression. The present study aimed to evaluate the frequency of depression and anxiety and their potential relation with serum apelin levels among PD patients.Methods: A total of 40 PD patients were enrolled into the study. Depressive symptoms and anxiety were assessed with the Beck’s Depression Inventory and the Beck’s Anxiety Inventory. Serum apelin-12 levels were measured by immunoenzymatic assays using commercially available ELISA kit for standard human apelin.Results: Of the patients, 16 (40%) had depression, 20 (50%) had anxiety. The patients with depression and anxiety had a significantly longer time on dialysis (p?<?0.001 for both), significantly higher serum apelin (p?<?0.001 for both) and C-reactive protein levels (p?<?0.001 for both) than those without depression and anxiety. In multivariate analysis, serum apelin was the only parameter associated independently with depression and anxiety scores.Conclusions: A substantial number of PD patients had depression and anxiety. Increased levels of serum apelin may constitute a significant independent predictor of development of depression and anxiety in PD patients. 相似文献
998.
999.
E. Bora R. Soylar Z. Arıkan-Ayyıldız N. Uzuner Ö. Giray-Bozkaya D. Erçal Ö. Karaman A. Ülgenalp 《Allergologia et immunopathologia》2013,41(1):11-16
BackgroundPolymorphisms of plasminogen activator inhibitor-1 (PAI-1) and angiotensin-converting enzyme (ACE) genes have been implicated in susceptibility to asthma. In this study, we aimed to investigate whether there was any association between childhood asthma and polymorphisms of the PAI-1 and ACE genes.MethodsTwo hundred and three Turkish children aged 5–15 years, including 102 asthmatic patients and 101 healthy control subjects were included in this study. The asthma group was divided into two groups as follows: Group I: Asthmatic children with positive family history for atopy (n = 53), Group II: Asthmatic children without any family history for atopy (n = 49). One hundred and twenty-eight atopic family members were also included in the study. The insertion/deletion (I/D) polymorphism of the ACE and PAI-1 4G/5G gene polymorphisms was carried out by polymerase chain reaction.ResultsThe prevalence of the PAI-1 4G allele was significantly greater in asthmatic children compared to control group (p < 0.05, OR: 1.64 (1.11–2.43)) but there was no significant relation between ACE I/D genotypes and childhood asthma. No significant difference was detected between Groups I and II in terms of these ACE and PAI-1 genotypes and allele frequencies. No significant relationship was found between both gene polymorphisms and total serum IgE and skin prick test results.ConclusionIt has been established that PAI-1 4G allele may be a genetic risk factor for childhood asthma but ACE gene I/D polymorphisms do not play a role in the development of asthma in the sample of Turkish children. 相似文献
1000.