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21.
Diabetic nephropathy and anaemia 总被引:2,自引:0,他引:2
22.
S. Ritz R. Stock H. W. Schütz H. -J. Kaatsch 《International journal of legal medicine》1995,108(3):135-139
Determination of age at death on the basis of aspartic acid racemization in dentin is one of the most reproducible and accurate methods. In Germany, age estimation by this method has so far generally not been applied to living persons, since the extraction of a tooth exclusively for age estimation when it is not medically indicated is regarded as ethically and legally problematic. The development of a biopsy technique applicable to dentin took place against this background. Testing the technique and analysis of dentinal biopsy specimens revealed that the biopsy technique is a low-risk procedure that causes only minor discomfort to the affected person. It is readily practicable and facilitates standardized specimen removal. The relationship between the extent of aspartic acid racemization in dentinal biopsy specimens and age is very close, facilitating age estimation. A prerequisite for accurate results is the performance of biopsies under strictly standardized conditions. If this is guaranteed, age determination on the basis of aspartic acid racemization in dentinal biopsy specimens appears to be superior in precision to most other methods in living persons and can be used for all age groups. 相似文献
23.
Excess of DD homozygotes in haemodialysed patients with type II diabetes. The Diabetic Nephropathy Study Group 总被引:1,自引:0,他引:1
Schmidt S; Strojek K; Grzeszczak W; Bergis K; Ritz E 《Nephrology, dialysis, transplantation》1997,12(3):427-429
The role of the insertion/deletion polymorphism of the angiotensin-
converting enzyme (ACE) gene in the genesis of diabetic nephropathy has
been controversial. It has recently been proposed that progression occurs
more rapidly in individuals with diabetic and non-diabetic renal disease
who are homozygous for the D allele. We studied 658 patients with type II
diabetes, 347 without diabetic nephropathy and 311 with various stages of
diabetic nephropathy, and determined the I/D polymorphism of the ACE gene.
Patients at the extremes of renal risk, i.e. normotensive patients without
antihypertensive treatment and without nephropathy (n = 144), vs patients
on dialysis (n = 61), differed with respect to genotype (DD 36.8% vs 57.4%;
P = 0.007) and allele frequencies (D 0.59 vs 0.76; P < 0.001). In
contrast, patients with and without presumed nephropathy as assessed by
albuminuria did not differ with respect to DD genotype. In conclusion, in
this study, which was limited by sample size, patients with the highest
renal risk more frequently had the DD genotype. This would be compatible
with a greater risk of (or rate of) progression to end-stage renal failure.
相似文献
24.
25.
Diffuse intermyocardiocytic fibrosis in uraemic patients 总被引:11,自引:2,他引:9
At post-mortem we examined heart tissue of (i) 31 patients with uraemia not on dialysis, (ii) 42 patients on haemodialysis for less than 6 months, (iii) 60 patients on haemodialysis for more than 6 months, (iv) 16 patients after renal transplantation, and (v) 11 patients on CAPD. Patients with stenosing coronary lesions were excluded. Diffuse non-coronary intermyocardiocytic fibrosis, assessed by a score system in trichrome-stained sections, was found in 91% of chronically uraemic patients, but not in non-hypertensive, non-diabetic controls. The lesion was present even in non-dialysed uraemic patients; in dialysed patients its severity was related to the duration of dialysis; it was demonstrable even years after renal transplantation. On electron-microscopy, collagen fibres were seen, while beta 2-M amyloid was consistently absent. Logistic regression analysis showed that uraemia was a determinant of intermyocardiocytic fibrosis independent of hypertension, diabetes mellitus, anaemia, heart weight, and presence or absence of dialysis procedure. 相似文献
26.
Eberhard Göpel 《Zeitschrift fur Gesundheitswissenschaften》2004,12(3):237
Ohne Zusammenfassung 相似文献
27.
Eberhard Unsöld Christian Ell Dieter Jocham Ronald Sroka Susanne Stocker 《Lasers in medical science》1990,5(3):309-316
Eight commercially available HPD-photosensitizers intended for photodynamic therapy were tested in a murine tumour model with regard to their therapeutic efficacy. The regrowth delay of the fibrosarcoma SSK-2 on the mouse C3H, Neuherberg-line, was determined 3, 24, 48 and 72 h after injection of the drugs (dose: 9 mg kg–1 body weight). The corresponding pharmacodynamics, as measured by regrowth delay, were approximated by an exponential function and the characterizing coefficients derived. These coefficients served to quantify the photodynamic properties of the drugs.The pharmacodynamics of five substances were compared with those obtained fluorometrically. The latter showed shorter decay constants than the therapy-correlated substances which indicates different metabolic behaviour of the therapeutic and diagnostically useful fluorescent components of haematoporphyrin-derived photosensitizers. 相似文献
28.
Intramolecular Alkylations of Aromatic Compounds, XVII1): — Synthesis of trans-3,10b-Dimethyl-1,2,3,4,4a,5,6,10b-octahydrobenzo(f)isoquinoline From the cyanhydrine 5b , easily obtained from 4 and trimethylsilyl cyanide, the lactone 6 is prepared, hydrogenation of which gives a mixture of the lactam 7a and the lactone 8 . Compound 7a is reduced to the secondary base 9 , which by treatment with acid is dehydrated to 10 and rearranges to give the isomer 11 , too. Attempted cyclization of the aminoalcohol 12 fails to give 9 or 10 . Rather, the furan 13 is isolated as the final product. N-methylation 10 → 14 and subsequent hydrogenation furnish the 4:1 trans/cis-mixture 2a, b , from which the title compound is separated by column chromatography. From 11 the stereomers 18a, b can be prepared analogously. 相似文献
29.
Hoschek Stefan Hoschek-Risslegger Ursula Fiegl Michael Zabernigg August Pall Georg Auberger Thomas Gunsilius Eberhard Schmid Thomas Jamnig Herbert Hilbe Wolfgang 《Wiener Medizinische Wochenschrift》2007,157(21):562-568
Wiener Medizinische Wochenschrift - Aggressives Tumorwachstum, frühe Metastasierung und hohe Assoziation mit intensivem Nikotinkonsum sind die Charakteristika des kleinzelligen... 相似文献
30.
A. Pansky F. Peng M. Eberhard L. Baselgia W. Siegrist J. B. Baumann A. N. Eberle C. Beglinger & P. Hildebrand 《European journal of clinical investigation》1996,27(1):69-76
Bombesin was originally isolated from amphibian skin, wherease its mammalian counterpart, gastrin-releasing peptide (GRP), was first identified in the nervous system of the gastrointestinal tract. Whether GRP is present in the human skin is not known. Bombesin-like peptides are also known to modulate growth. We therefore investigated whether human melanoma cell lines express functional GRP-preferring bombesin receptors and whether they alter growth or other specific cellular functions of these tumour cells. GRP receptor mRNA was found in HBL, D-10, Me-28 and A375-6 cell lines, but only A375-6 cells express a large number of high-affinity binding sites for [125 I]-[Tyr4 ] bombesin ( K d 0.31 ± 0.04 nmol L−1 , 3880 ± 429 binding sites per cell). Bombesin dose-dependently increased cytosolic calcium, but did not alter interleukin (IL) 1β-induced reduction of cell viability or IL-6 secretion, both A375-6-specific cell functions. Growth of A375-6 cells was not altered by bombesin or the specific GRP receptor antagonist BIM26226 as measured by [3 H]-thymidine incorporation or methylene blue assay, whereas insulin alone or in combination with other potential growth factors dose-dependently stimulated growth of these cells. The newly characterized GRP-preferring bombesin receptors on highly malignant human melanoma cells could initiate studies of growth effects on solid tumours or in vivo scanning using radiolabelled tracers. 相似文献