A 3‐year prospective radiographic evaluation of marginal bone level around different implant systems

Summary The aim of this study was to evaluate the change of marginal bone level radiographically around three different implant systems after 3 years in function. Fifty‐four patients were included and randomly assigned to three treatment groups of rough‐surface implants (TiUnite, n = 37), hybrid of smooth and rough‐surface implants (Restore, n = 38) and rough surface with microthread implants (Hexplant, n = 45). Clinical and radiographic examinations were conducted at the time of implant loading (baseline), 1 and 3 years after loading. A three‐level mixed‐effect analysis of covariance (ancova ) was used to test the significance of the mean marginal bone change of the three implant groups. A total 120 of 135 implants completed the study. None of the implants failed to integrate. Significant differences were noted in the marginal bone loss recorded for the three groups (P < 0·0001). At 3 years, the rough surface with microthread implants had a mean crestal bone loss of 0·59 ± 0·30 mm; the rough‐surface implants, 0·95 ± 0·27 mm; and the hybrid surface implants, 1·05 ± 0·34 mm. Within the limitations of this study, rough‐surface implants with microthread at the coronal part might have a long‐term positive effect in maintaining the marginal bone level against functional loading in comparison with implants without these two features.     

Successful Treatment of Lichen Spinulosus with Topical Tacalcitol Cream

Abstract: Lichen spinulosus (LS) is a rare idiopathic cutaneous eruption characterized by follicular keratotic spiny papules that are grouped in large patches. Here, we report two cases of LS in the submental area, an uncommon site, which were treated effectively and safely with topical tacalcitol cream.     

Severe Thigh Abscess Two Years after Transobturator Sling Operation

Objectives: Tension‐free vaginal tape has gained large popularity owing to the ease of the procedure and its effectiveness. These procedures were initially thought to rarely involve any significant morbid complications. The transobturator tape (TOT) procedure reproduces the natural suspension similar to the tension‐free vaginal tape with a reduction in potential bladder, bowel, and vascular complications by the retropubic approach. However, the TOT procedure is not risk‐free when improperly performed. We report a rare case of abscess formation after TOT. Methods: A 45‐year‐old woman was admitted to the orthopedic department with the chief complaint of right side thigh pain and swelling. Pelvis MRI showed abscess formation and inflammatory changes extending into the soft tissues and muscles between the right gracilis and adductor femoris. During incision and open drainage, the remnant mesh could not be located. On urologic consult, the pelvic examination located the remnant mesh to the right upper vaginal wall. Our patient underwent excision of the mesh material. Results: She had significant improvement of the leg pain and was discharged home in good condition on postoperative day 7. Ultimately, the treatment for this complication was the removal of the mesh. Conclusion: Treatment for thigh abscess after TOT was the removal of the mesh. All patients should be counseled about this potential complication.     

Interferon-α is a Potent Inhibitor of Basic Fibroblast Growth Factor-Stimulated Cell Proliferation in Human Uterine Cells

PROBLEM: Abnormal uterine bleeding is a significant health problem for many women and is the number-one reason for performing hysterectomy in the United States. Leiomyomas (uterine fibroids) are benign neoplams that are a frequent cause of abnormal uterine bleeding. The goal of this study was to assess the effects of the anti-angiogenic cytokine, interferon (INF)-α, on the proliferation of both leiomyoma and normal uterine cells. METHOD OF STUDY: Primary cultures of leiomyoma, myometrial, and endometrial stromal cells were established for in vitro study. The effects of INF-α (10, 100, and 1000 U/ml) were tested on serum-stimulated and basic fibroblast growth factor-stimulated cell proliferation using the [³H]thymidine incorporation assay. RESULTS: INF-α was a potent inhibitor of cell proliferation for all three cell types, with endometrial stromal cells showing the greatest sensitivity. The antiproliferative effect did not appear to result from toxic effects on the cells. CONCLUSION: INFs may prove to be useful therapeutic agents for the treatment of leiomyoma-related abnormal uterine bleeding.     

Magnetic resonance imaging for assessment of deep endometrial invasion for patients with endometrial carcinoma

Aims: To evaluate the value of magnetic resonance imaging (MRI) for the detection of deep myometrial invasion.
Methods: The patient group consisted of 53 women with endometrial cancer who underwent preoperative workup, including MRI, and surgical staging between August 1999 and August 2008 at Korea University Medical Center, Seoul, South Korea. The pathological data from surgical staging were compared with the preoperative MRI results.
Results: The mean age of the patients was 51 years and most patients had endometrioid cancer. On pathological evaluation of the myometrium, 20.8% had a deep myometrial invasion. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value of MRI in detecting deep myometrial invasion were 50.0%, 89.7%, 79.2%, 63.6% and 83.3%, respectively. Evaluation of MRI findings and tumour grades by preoperative biopsy had a sensitivity and specificity of 88.9% and 87.5%, respectively, with a kappa of 0.764.
Conclusion: In patients with endometrial cancer, MRI is limited in its ability to detect deep myometrial invasion. The combination of MRI findings and tumour histology or grade can be helpful in determining if lymphadenectomy is necessary.     

高圆圆:用心感受30岁

入行13年,30岁的高圆圆依然不习惯用绯闻和隐私来提高知名度.她对事业不主动、不积极:面对媒体,只(要开)口,就是真话,宁愿闭嘴也不 撒谎.有媒体这样形容她:"她所追求的,并非阳春白雪,也非事业辉煌,?而是内心的平衡与快乐.有人在用身体与世界肉搏,她则用心灵与人生肉搏."