全文获取类型
收费全文 | 175篇 |
免费 | 9篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 7篇 |
妇产科学 | 1篇 |
基础医学 | 17篇 |
口腔科学 | 3篇 |
临床医学 | 14篇 |
内科学 | 44篇 |
皮肤病学 | 21篇 |
神经病学 | 4篇 |
特种医学 | 29篇 |
外科学 | 19篇 |
综合类 | 4篇 |
预防医学 | 11篇 |
药学 | 3篇 |
中国医学 | 2篇 |
肿瘤学 | 6篇 |
出版年
2022年 | 1篇 |
2021年 | 2篇 |
2019年 | 1篇 |
2018年 | 4篇 |
2017年 | 4篇 |
2016年 | 1篇 |
2015年 | 2篇 |
2014年 | 6篇 |
2013年 | 9篇 |
2012年 | 6篇 |
2011年 | 6篇 |
2010年 | 9篇 |
2009年 | 5篇 |
2008年 | 6篇 |
2007年 | 7篇 |
2006年 | 6篇 |
2005年 | 9篇 |
2004年 | 2篇 |
2003年 | 2篇 |
2002年 | 1篇 |
2001年 | 1篇 |
2000年 | 1篇 |
1998年 | 5篇 |
1997年 | 7篇 |
1996年 | 5篇 |
1995年 | 6篇 |
1994年 | 7篇 |
1993年 | 3篇 |
1992年 | 4篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 6篇 |
1987年 | 3篇 |
1986年 | 4篇 |
1985年 | 7篇 |
1984年 | 3篇 |
1983年 | 4篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 3篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 1篇 |
1975年 | 2篇 |
1961年 | 1篇 |
排序方式: 共有185条查询结果,搜索用时 0 毫秒
181.
P-selectin glycoprotein ligand-1 (PSGL-1) is a ligand for L-selectin in neutrophil aggregation 总被引:9,自引:3,他引:9
Guyer DA; Moore KL; Lynam EB; Schammel CM; Rogelj S; McEver RP; Sklar LA 《Blood》1996,88(7):2415-2421
In inflammation, activated neutrophils adhere to endothelial cells and aggregate with one another. While beta 2-integrin and L-selectin are essential for aggregation, their ligands remain to be identified. We have previously shown that L-selectin mediates a carbohydrate-dependent interaction in aggregation (Simon et al: J Immunol 149:2765, 1992; Rochon et al: J Immunol 152:1385, 1994). We have suggested that the L- selectin counter-structure is a mucinlike protein and proposed that aggregation occurs through a two-step process involving L-selectin, beta 2-integrin, and their distinct counter-structures (Bennett et al: J Leuk Biol 58:510, 1995). A candidate ligand for L-selectin is P- selectin glycoprotein ligand-1 (PSGL-1), a mucinlike protein on neutrophils that binds P-and E-selectin. Using flow cytometry we show that the number and size of neutrophil aggregates is reduced with Fab fragments of PL1, an anti-PSGL-1 monoclonal antibody that blocks the interaction between P-selectin and PSGL-1 (Moore et al: J Cell Biol 128:661, 1995). In addition, monoclonal antibodies to L-selectin and PSGL-1 were used simultaneously to modulate the availability of these adhesion molecules on individual cell populations. The inhibition of aggregation by these antibodies is consistent with L-selectin and PSGL- 1 being counter-structures. We suggest that L-selectin and PSGL-1 support a collisional cell-cell interaction that represents the first step in neutrophil aggregation. 相似文献
182.
Drossaers-Bakker KW; Hamburger HL; Bongartz EB; Dijkmans BA; Van Soesbergen RM 《Rheumatology (Oxford, England)》1998,37(8):889-894
Sleep apnoea syndrome (SAS) is a rarely documented, but possibly lethal,
complication of the instability of the cervical spine in rheumatoid
arthritis. Five patients with SAS of a central or peripheral origin are
presented, and the problems of recognizing and diagnosing the syndrome are
discussed. We hope that clinicians will become more aware of the existence
and the different aetiologies of SAS, thus improving early recognition and
appropriate treatment. Adequate treatment has proven to increase survival
in peripheral SAS and seems to be successful in doing so in central SAS.
相似文献
183.
Suzanne G St Rose Nora Hunter Louise Matthews James D Foster Margo E Chase-Topping Loeske EB Kruuk Darren J Shaw Susan M Rhind Robert G Will Mark EJ Woolhouse 《BMC infectious diseases》2006,6(1):5
Background
Epidemiological analyses indicate that the age distribution of natural cases of transmissible spongiform encephalopathies (TSEs) reflect age-related risk of infection, however, the underlying mechanisms remain poorly understood. Using a comparative approach, we tested the hypothesis that, there is a significant correlation between risk of infection for scrapie, bovine spongiform encephalopathy (BSE) and variant CJD (vCJD), and the development of lymphoid tissue in the gut. 相似文献184.
Donation reactions among autologous donors 总被引:2,自引:0,他引:2
PA McVay ; A Andrews ; EB Kaplan ; DB Black ; LC Stehling ; RG Strauss ; PT Toy 《Transfusion》1990,30(3):249-252
Studies of risk factors associated with reactions among autologous blood donors have been limited. Therefore, 2091 autologous and 4737 homologous donations were examined. Donors at greatest risk for reaction were autologous donors who had reactions at first donation; among 45 who made repeat donations for the same surgery, 17 (38%) had repeat reactions. The group least likely to experience reactions were the autologous donors greater than or equal to 66 years old; they experienced a 1.9 greater than or equal to percent (6/310) incidence of reactions. More reactions were seen in both autologous and homologous donors in the categories of first-time donor, female gender, decreasing age, and lower weight. Multiple logistic regression analysis showed that all of these variables were independent predictors of donor reaction, with first-time donation (odds ratio, 2.4) and female gender (odds ratio, 1.9) being the strongest predictors of reaction. Donor room personnel should be alerted that autologous donors who react at first donation are very likely to react at subsequent donations. Contrary to common concern, elderly autologous donors are least likely to have reactions. 相似文献
185.
A model to determine required pool size for HLA-typed community donor apheresis programs 总被引:2,自引:0,他引:2
Community donor plateletpheresis programs must have adequate numbers of HLA-typed donors to support the transfusion needs of alloimmunized patients, and donor pool size calculations should reflect the fact that each patient needs more than one donor to provide his or her support. The average number of donors needed to provide a patient's support was estimated as a function of donor usage and commitment. A model was developed for determining an appropriate size of the donor pool for a community donor plateletpheresis program that would incorporate the average number of donors needed per patient, the level of HLA compatibility to be maintained between patient and donor, and the frequencies of patient and donor HLA phenotypes. A database of 4338 plateletpheresis transfusions given to 591 patients from a pool of up to 870 community donors over a 3-year period was analyzed retrospectively to validate the estimates of the average number of donors needed to support a patient, which ranged from 4 to 33 donors. This database was also used to illustrate the application of the pool size determination model. Model results suggest that plateletpheresis donor pools of 1000 to 3000 donors are capable of meeting the transfusion needs of most patients at an HLA-match grade of B2 or better. 相似文献