全文获取类型
收费全文 | 2172871篇 |
免费 | 152307篇 |
国内免费 | 3201篇 |
专业分类
耳鼻咽喉 | 29736篇 |
儿科学 | 66396篇 |
妇产科学 | 58942篇 |
基础医学 | 315056篇 |
口腔科学 | 63394篇 |
临床医学 | 195597篇 |
内科学 | 420362篇 |
皮肤病学 | 46459篇 |
神经病学 | 169440篇 |
特种医学 | 85689篇 |
外国民族医学 | 429篇 |
外科学 | 326662篇 |
综合类 | 41979篇 |
现状与发展 | 3篇 |
一般理论 | 777篇 |
预防医学 | 167909篇 |
眼科学 | 49520篇 |
药学 | 162944篇 |
11篇 | |
中国医学 | 4020篇 |
肿瘤学 | 123054篇 |
出版年
2018年 | 23550篇 |
2017年 | 19271篇 |
2016年 | 20156篇 |
2015年 | 24261篇 |
2014年 | 31215篇 |
2013年 | 44389篇 |
2012年 | 65040篇 |
2011年 | 63768篇 |
2010年 | 36844篇 |
2009年 | 36920篇 |
2008年 | 59091篇 |
2007年 | 63136篇 |
2006年 | 63847篇 |
2005年 | 69260篇 |
2004年 | 68476篇 |
2003年 | 62189篇 |
2002年 | 56513篇 |
2001年 | 102563篇 |
2000年 | 103681篇 |
1999年 | 89821篇 |
1998年 | 22736篇 |
1997年 | 20179篇 |
1996年 | 20654篇 |
1995年 | 19354篇 |
1994年 | 18024篇 |
1993年 | 16733篇 |
1992年 | 71562篇 |
1991年 | 69978篇 |
1990年 | 68091篇 |
1989年 | 66166篇 |
1988年 | 61102篇 |
1987年 | 59604篇 |
1986年 | 56313篇 |
1985年 | 53100篇 |
1984年 | 39189篇 |
1983年 | 33660篇 |
1982年 | 18565篇 |
1979年 | 36775篇 |
1978年 | 25844篇 |
1977年 | 21643篇 |
1976年 | 19526篇 |
1975年 | 21942篇 |
1974年 | 26839篇 |
1973年 | 25733篇 |
1972年 | 24551篇 |
1971年 | 23211篇 |
1970年 | 21940篇 |
1969年 | 20828篇 |
1968年 | 19230篇 |
1967年 | 17443篇 |
排序方式: 共有10000条查询结果,搜索用时 281 毫秒
91.
92.
93.
94.
Benyam Kinde Harrison W. Gabel Caitlin S. Gilbert Eric C. Griffith Michael E. Greenberg 《Proceedings of the National Academy of Sciences of the United States of America》2015,112(22):6800-6806
DNA methylation at CpG dinucleotides is an important epigenetic regulator common to virtually all mammalian cell types, but recent evidence indicates that during early postnatal development neuronal genomes also accumulate uniquely high levels of two alternative forms of methylation, non-CpG methylation and hydroxymethylation. Here we discuss the distinct landscape of DNA methylation in neurons, how it is established, and how it might affect the binding and function of protein readers of DNA methylation. We review studies of one critical reader of DNA methylation in the brain, the Rett syndrome protein methyl CpG-binding protein 2 (MeCP2), and discuss how differential binding affinity of MeCP2 for non-CpG and hydroxymethylation may affect the function of this methyl-binding protein in the nervous system. 相似文献
95.
96.
Provocation of Atrial Fibrillation Triggers During Ablation: Does the Use of General Anesthesia Affect Inducibility?
下载免费PDF全文
![点击此处可从《Journal of cardiovascular electrophysiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
97.
A case of bullous pemphigoid associated with psoriasis vulgaris showing Hailey–Hailey disease‐like histopathological changes in regenerated epidermis without genomic mutation in ATP2C1 or ATP2A2 gene
下载免费PDF全文
![点击此处可从《Journal of the European Academy of Dermatology and Venereology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
98.
F. Fruzzetti G. Palla A. Sbrana T. Simoncini M. R. Sessa 《Gynecological endocrinology》2020,36(10):938-940
AbstractObjective: To understand the origin of extremely high gonadotropin levels in a perimenopausal woman.Methods: A 52-year-old woman with a 2?months of amenorrhea followed spontaneous menstrual cycles recovery was referred to our outpatient clinic with elevated follicle-stimulating hormone (FSH, 483 mUI/ml), luteinizing hormone (LH, 475 mUI/ml) and prolactin (PRL, 173?ng/ml). She was known to take levosulpiride. The gonadotropin levels did not fit with the clinical features.Results: A gonadotroph tumor was ruled out. Further analysis confirmed constantly high FSH, LH and PRL levels. The measurements were repeated using different analytical platforms with different results. After serial dilutions, nonlinearity was present suggesting an immunoassay interference. After post-polyethylene glycol recovery, hormone levels appeared in the normal range. Anti-goat antibodies were recognized in the serum of the patient.Conclusions: This case report shows a case of falsely abnormal high gonadotropin and PRL levels in a woman during menopause transition. In the clinical practice the evaluation of gonadotropin profile is not recommended at this age, but the abnormal levels stimulated further evaluation. An interference in the assay due to anti-goat antibodies resulted in abnormally high level of FSH and LH. A strict collaboration between clinicians and the laboratory is needed, when laboratory findings do not correspond to clinical findings. 相似文献
99.
Anatoly E Martynyuk Ling-Sha Ju Timothy E Morey Jia-Qiang Zhang 《World Journal of Psychiatry》2020,10(5):81-94
The progress of modern medicine would be impossible without the use of general anesthetics (GAs). Despite advancements in refining anesthesia approaches, the effects of GAs are not fully reversible upon GA withdrawal. Neurocognitive deficiencies attributed to GA exposure may persist in neonates or endure for weeks to years in the elderly. Human studies on the mechanisms of the long-term adverse effects of GAs are needed to improve the safety of general anesthesia but they are hampered not only by ethical limitations specific to human research, but also by a lack of specific biological markers that can be used in human studies to safely and objectively study such effects. The latter can primarily be attributed to an insufficient understanding of the full range of the biological effects induced by GAs and the molecular mechanisms mediating such effects even in rodents, which are far more extensively studied than any other species. Our most recent experimental findings in rodents suggest that GAs may adversely affect many more people than is currently anticipated. Specifically, we have shown that anesthesia with the commonly used GA sevoflurane induces in exposed animals not only neuroendocrine abnormalities (somatic effects), but also epigenetic reprogramming of germ cells (germ cell effects). The latter may pass the neurobehavioral effects of parental sevoflurane exposure to the offspring, who may be affected even at levels of anesthesia that are not harmful to the exposed parents. The large number of patients who require general anesthesia, the even larger number of their future unexposed offspring whose health may be affected, and a growing number of neurodevelopmental disorders of unknown etiology underscore the translational importance of investigating the intergenerational effects of GAs. In this mini review, we discuss emerging experimental findings on neuroendocrine, epigenetic, and intergenerational effects of GAs. 相似文献
100.
T. Wu L. G. Trahair M. J. Bound C. F. Deacon M. Horowitz C. K. Rayner K. L. Jones 《Diabetic medicine》2015,32(5):595-600