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71.
72.
Fernández-Ávila Daniel Gerardo Patino-Hernandez Daniela Kowalskii Sergio Vargas-Caselles Alfredo Sapag Ana Maria Cachafeiro-Vilar Antonio Meléndez-Muñoz Lucia Santiago-Pastelín Carlos Graf Cesar Rossetto Chayanne Palleiro Daniel Trincado Daniela Fernández-Ávila Diana Arrieta Dina Reyes Gil Then Baez Jossiel Ugarte-Gil Manuel F. Cardiel Mario Colman Nelly Chávez Nilmo Burgos Paula I Montúfar Ruben Sandino Sayonara Fuentes-Silva Yurilis Soriano Enrique R. 《Clinical rheumatology》2021,40(7):2913-2920
Clinical Rheumatology - Studies conducted by various scientific societies have shown that the demand for specialized rheumatology care is greater than the projected growth of the workforce. Our... 相似文献
73.
Merashli Mira Arcaro Alessia Graf Maria Gentile Fabrizio Ames Paul R. J. 《Clinical rheumatology》2021,40(5):1967-1973
Clinical Rheumatology - The relationship between autoimmune haemolytic anaemia (AIHA) and antiphospholipid antibodies (aPL) has never been addressed via a meta-analysis in the paediatric age group.... 相似文献
74.
Limperger Verena Kenet Gili Kiesau Bettina Köther Max Schmeiser Malin Langer Florian Juhl David Shneyder Maria Franke Andre Klostermeier Ulrich K. Mesters Rolf Rühle Frank Stoll Monika Steppat Dagmar Kowalski Dorothee Rocke Angela Kuta Piotr Bajorat Tido Torge Antje Neuner Bruno Junker Ralf Nowak-Göttl Ulrike 《Journal of thrombosis and thrombolysis》2021,51(2):494-501
Journal of Thrombosis and Thrombolysis - The role of the A>G polymorphism at position 19911 in the prothrombin gene (factor [F] 2 at rs3136516) as a risk factor for venous thromboembolism... 相似文献
75.
Van Geertruyden JP Ntakirutimana D Erhart A Rwagacondo C Kabano A D'Alessandro U 《Tropical medicine & international health : TM & IH》2005,10(7):681-688
OBJECTIVES: The aim of the study was to assess the knowledge, attitude and practices of pregnant women towards malaria and their association with malaria morbidity. METHODS: Cross-sectional malaria survey of 1432 pregnant women attending six health centres, each of them situated in a specific health district in Rwanda from September to October 2002. RESULTS: The overall prevalence of malaria infection was 13.6% and all infections but two were caused by Plasmodium falciparum. The six health districts were significantly different in terms of malaria prevalence, which varied between 11.5% and 15.4% in four and was <5% in the other two districts. The prevalence of anaemia and splenomegaly mirrored that of malaria infection. In three districts, the prevalence of infection was significantly higher in primigravidae than in secundigravidae and multigravidae (P = 0.01), while in two others it did not vary with parity. Bed net use was low - only 13.1% of the women had at least one bed net at home and 8.3% of them slept under it - and significantly different between districts. Most women knew that malaria might have serious consequences for their pregnancy and that insecticide-treated bed nets are useful for malaria prevention. However, the bed net market price [1525 Rwandan Francs (RFr), approximately 1.6] was much higher than that considered as affordable and acceptable (389 RFr, approximately 0.3). CONCLUSION: Malaria in pregnancy is a major problem in Rwanda, even in the districts of low transmission. Bed net use among pregnant women is low. The option of providing free insecticide-treated bed nets to pregnant women should be explored and possibly implemented; it could rapidly increase bed net use and earlier attendance to antenatal clinics with clear benefits for the women's health. 相似文献
76.
Zusammenfassung
Fragestellung Die Diskriminierungsf?higkeit bezüglich überleben und Versterben sowie die Kalibrierung der Mortalit?tsprognose durch das
Mortality Probability Model (MPM II) sollte in dieser prospektiven Studie bei Patienten einer kardiologischen Intensivstation
evaluiert werden. Methode Alle konsekutiven Patienten der kardiologischen Intensivstation mit einer Liegedauer >12 Stunden wurden zwischen 12/97 und
2/98 in diese prospektive Studie eingeschlossen (Ausschluss: Wiederaufnahmen). MPM II wurde bei Aufnahme (MPM II0), nach 24 (MPM II24), 48 (MPM II48) und 72 Stunden (MPM II72) erhoben. SAPS II wurde nach 24 Stunden bestimmt. Die Wahrscheinlichkeit der Krankenhausmortalit?t (Pr) für die jeweiligen
Modelle wurde berechnet. Die Fl?che unter der Receiver Operating Characteristic (AUC) Kurve diente zur Analyse der Diskriminierungsf?higkeit.
Die Kalibrierung der Modelle wurden anhand der standardisierten Mortalit?tsratio (SMR) und dem Goodness of fit (GOF) Test
untersucht. Ergebnisse 303 Patienten (62,4±12,6 Jahre, 71,3% M?nner) wurden eingeschlossen. Die Intensivmortalit?t betrug 8,3%, die Krankenhausmortalit?t
14,5%. Die mittlere Liegedauer auf der Intensivstation lag bei 3,7 Tage (1–36 Tage), die mittlere Krankenhausliegedauer bei
15,2 Tage (1–79). Pr war in beiden Modellen für nicht überlebende Patienten signifikant h?her. AUC (±SD): SAPS II 0,77±0,05,
MPM II0 0,77±0,04, MPM II24 0,72±0,05, MPM II48 0,85±0,05 und MPM II72 0,78±0,06. Die SMR für SAPS II betrug 1,25 (0,91–1,69), für MPM II0 1,37 (0,99–1,84), MPM II24 1,32 (0,89–1,87), MPM II48 1,07 (0,69–1,58) und für MPM II72 1,19 (0,74–1,82). Der GOF-C-Test zeigte einen signifikanten Unterschied zwischen vorhergesagter und beobachteter Mortalit?t
für den MPM II0 (χ2=39,44 [p<0,001, df=9]), der GOF H Test für den MPM II72 (χ2=15,35 [p=0,01, df=6]). Diagnose- und Alterskategorien sowie Aufnahmemodus wiesen ebenfalls variable SMRs auf. Schlussfolgerung Die Mortalit?tsvorhersage durch das MPM-II-Modell war zufriedenstellend. Die SMR zeigte jedoch eine statistisch nicht signifikante
Untersch?tzung der Mortalit?t. Die Abweichung der vorhergesagten von der beobachteten Mortalit?t trat v.a. in den h?heren
Risikostrata auf. Eine unterschiedliche Patientenselektion („case mix”) und divergente Vorbehandlungen der Patienten („lead
time”) beeinflussen die Performance von MPM II0–72. Daher scheint eine Anpassung des Vorhersagemodells an die Zielpopulation („customization”) erforderlich zu sein.
Eingegangen: 12. M?rz 2001 Akzeptiert: 5. April 2001 相似文献
77.
Summary Studies of homograft valves in the past two decades have suggested that viable valves, i.e., those maintaining chemical and structural integrity of their leaflet intercellular matrix, have a better long-term function than nonviable valves. The most effective qualitative methods of assessing leaflet viability involve destruction of the valve leaflets; thus, these methods have been limited to random use in selected valves. A study was conducted in swine in an attempt to establish a control tissue which could be tested in place of the homograft leaflets, thereby determining viability levels of every valve clinically implanted and correlating the results with long-term clinical function. Thirty samples each of the aortic and pulmonary artery wall and tricuspid leaflet were compared with aortic and pulmonary leaflets. Utilizing the technique of C14-proline uptake, viability was assessed at procurement, following sterilization, and following cryopreservation and short-term storage. The tricuspid leaflet was found to retain the same level of viability as the aortic and pulmonary leaflets before and after the cryopreservation period. It was concluded that the tricuspid leaflet could be utilized as the control tissue. 相似文献
78.
Oxana Norkina Rolf Graf Philippe Appenzeller Robert C De Lisle 《BMC gastroenterology》2006,6(1):16-11
Background
The cystic fibrosis (CF) mouse pancreas has constitutively elevated expression of the Reg/PAP cell stress genes (60-fold greater Reg3α, and 10-fold greater PAP/Reg3β and Reg3γ). These genes are suggested to be involved in protection or recovery from pancreatic injury. 相似文献79.
Paolo Paganetti Julia Reichwald Dorothee Bleckmann Dorothee Abramowski Domenico Ammaturo Carmen Barske Simone Danner Maurizio Molinari Matthias Müller Stéphanie Papin Sabine Rabe Peter Schmid Matthias Staufenbiel 《Neurobiology of aging》2013,34(12):2866-2878
Heterologous expression of the functional amyloid beta (Aβ) antibody β1 in the central nervous system was engineered to maximize antibody exposure in the brain and assess the effects on Aβ production and accumulation in these conditions. A single open reading frame encoding the heavy and light chains of β1 linked by the mouth and foot virus peptide 2A was expressed in brain neurons of transgenic mice. Two of the resulting BIN66 transgenic lines were crossed with APP23 mice, which develop severe central amyloidosis. Brain concentrations at steady-state 5 times greater than those found after peripheral β1 administration were obtained. Similar brain and plasma β1 concentrations indicated robust antibody efflux from the brain. In preplaque mice, β1 formed a complex with Aβ that caused a modest Aβ increase in brain and plasma. At 11 months of age, β1 expression reduced amyloid by 97% compared with age-matched APP23 mice. Interference of β1 with β-secretase cleavage of amyloid precursor protein was relatively small. Our data suggest that severely impaired amyloid formation was primarily mediated by a complex of β1 with soluble Aβ, which might have prevented Aβ aggregation or favored transport out of the brain. 相似文献
80.
Helge Kampen Mandy Kronefeld Dorothee Zielke Doreen Werner 《Parasitology research》2013,112(2):905-907
After two previous demonstrations of introductions of the Asian tiger mosquito, Aedes albopictus, into southern Germany in 2007 and 2011, another three specimens were trapped in the city of Freiburg in the Upper Rhine Valley. The females were caught in early September 2011 (n?=?2) and mid-July 2012 (n?=?1). The trap was located at a railway container station where cargo is transferred to trains from trucks predominantly coming from southern Europe where A. albopictus is widely distributed. The reported findings confirm vehicle transport of A. albopictus to be an important and probably frequent mode of importation, and suggest that more regular and intense monitoring for invasive mosquito species in the Upper Rhine Valley should be undertaken in order to detect an establishment and implement adequate control measures in good time. 相似文献