全文获取类型
收费全文 | 332050篇 |
免费 | 62711篇 |
国内免费 | 16954篇 |
专业分类
耳鼻咽喉 | 3753篇 |
儿科学 | 6998篇 |
妇产科学 | 3658篇 |
基础医学 | 44918篇 |
口腔科学 | 9513篇 |
临床医学 | 45370篇 |
内科学 | 59776篇 |
皮肤病学 | 10219篇 |
神经病学 | 25550篇 |
特种医学 | 11699篇 |
外国民族医学 | 124篇 |
外科学 | 39373篇 |
综合类 | 43263篇 |
现状与发展 | 55篇 |
一般理论 | 52篇 |
预防医学 | 21556篇 |
眼科学 | 8051篇 |
药学 | 33351篇 |
260篇 | |
中国医学 | 16249篇 |
肿瘤学 | 27927篇 |
出版年
2024年 | 980篇 |
2023年 | 4114篇 |
2022年 | 10650篇 |
2021年 | 14698篇 |
2020年 | 14852篇 |
2019年 | 18761篇 |
2018年 | 18674篇 |
2017年 | 19292篇 |
2016年 | 19536篇 |
2015年 | 23530篇 |
2014年 | 26149篇 |
2013年 | 25681篇 |
2012年 | 24230篇 |
2011年 | 25659篇 |
2010年 | 22893篇 |
2009年 | 16210篇 |
2008年 | 16427篇 |
2007年 | 14715篇 |
2006年 | 14077篇 |
2005年 | 13217篇 |
2004年 | 9130篇 |
2003年 | 8564篇 |
2002年 | 7352篇 |
2001年 | 6178篇 |
2000年 | 5999篇 |
1999年 | 5549篇 |
1998年 | 3230篇 |
1997年 | 3230篇 |
1996年 | 2448篇 |
1995年 | 2464篇 |
1994年 | 2084篇 |
1993年 | 1255篇 |
1992年 | 1734篇 |
1991年 | 1457篇 |
1990年 | 1167篇 |
1989年 | 1100篇 |
1988年 | 980篇 |
1987年 | 842篇 |
1986年 | 658篇 |
1985年 | 520篇 |
1984年 | 253篇 |
1983年 | 206篇 |
1982年 | 123篇 |
1981年 | 155篇 |
1980年 | 97篇 |
1979年 | 133篇 |
1978年 | 60篇 |
1977年 | 59篇 |
1976年 | 49篇 |
1974年 | 52篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
51.
52.
53.
54.
随着腔镜技术的进一步发展以及微创理念应用于结直肠外科疾病的诊治中,结直肠相关疾病的诊治发生了翻天覆地的变化。由传统的经腹手术到腹腔镜手术、经自然腔道手术,再到经自然腔道取标本手术(NOSES),结直肠疾病的外科诊治在微创领域取得了巨大成果。NOSES技术是目前结直肠外科在微创领域前沿的手术方式之一,它通过经直肠、阴道取标本来避免了腹壁的辅助取标本切口,从而将结直肠外科手术进一步微创化。NOSES技术集传统腹腔镜手术的优势与现代微创外科的理念于一体,它在确保手术效果的基础上集中体现了微创、加速康复外科、功能外科、"无疤"等理念的特点。本文主要就国内外各中心开展NOSES技术在结直肠外科诊治开展中的相关经验、心得和体会进行综述。 相似文献
55.
56.
PNPLA3 gene polymorphism and response to lifestyle modification in patients with nonalcoholic fatty liver disease 下载免费PDF全文
57.
Tien‐Yao Tsai Iat‐Lon Leong Ka‐Shun Cheng Lian‐Ru Shiao Tzu‐Hui Su Kar‐Lok Wong Paul Chan Yuk‐Man Leung 《Fundamental & clinical pharmacology》2019,33(1):52-62
A pathological feature in atherosclerosis is the dysfunction and death of vascular endothelial cells (EC). Oxidized low‐density lipoprotein (LDL), known to accumulate in the atherosclerotic arterial walls, impairs endothelium‐dependent relaxation and causes EC apoptosis. A major bioactive ingredient of the oxidized LDL is lysophosphatidylcholine (LPC), which at higher concentrations causes apoptosis and necrosis in various EC. There is hitherto no report on LPC‐induced cytotoxicity in brain EC. In this work, we found that LPC caused cytosolic Ca2+ overload, mitochondrial membrane potential decrease, p38 activation, caspase 3 activation and eventually apoptotic death in mouse cerebral bEND.3 EC. In contrast to reported reactive oxygen species (ROS) generation by LPC in other EC, LPC did not trigger ROS formation in bEND.3 cells. Pharmacological inhibition of p38 alleviated LPC‐inflicted cell death. We examined whether heparin could be cytoprotective: although it could not suppress LPC‐triggered Ca2+ signal, p38 activation and mitochondrial membrane potential drop, it did suppress LPC‐induced caspase 3 activation and alleviate LPC‐inflicted cytotoxicity. Our data suggest LPC apoptotic death mechanisms in bEND.3 might involve mitochondrial membrane potential decrease and p38 activation. Heparin is protective against LPC cytotoxicity and might intervene steps between mitochondrial membrane potential drop/p38 activation and caspase 3 activation. 相似文献
58.
The analysis of quality of life (QoL) data can be challenging due to the skewness of responses and the presence of missing data. In this paper, we propose a new weighted quantile regression method for estimating the conditional quantiles of QoL data with responses missing at random. The proposed method makes use of the correlation information within the same subject from an auxiliary mean regression model to enhance the estimation efficiency and takes into account of missing data mechanism. The asymptotic properties of the proposed estimator have been studied and simulations are also conducted to evaluate the performance of the proposed estimator. The proposed method has also been applied to the analysis of the QoL data from a clinical trial on early breast cancer, which motivated this study. 相似文献
59.
60.
Leyi Wang Saraswathi Lanka Debbie Cassout Nohra E. Mateus‐Pinilla Ganwu Li William C. Wilson Dongwan Yoo Paul Shelton Richard L. Fredrickson 《Transboundary and Emerging Diseases》2019,66(5):1809-1820
First described in 1955 in New Jersey, epizootic haemorrhagic disease (EHD) causes a severe clinical disease in wild and domestic ruminants worldwide. Epizootic haemorrhagic disease outbreaks occur in deer populations each year from summer to late autumn. The etiological agent is EHD virus (EHDV) which is a double‐stranded segmented icosahedral RNA virus. EHD virus utilizes point mutations and reassortment strategies to maintain viral fitness during infection. In 2018, EHDV serotype 2 was predominantly detected in deer in Illinois. Whole genome sequencing was conducted for two 2018 EHDV2 isolates (IL41747 and IL42218) and the sequence analyses indicated that IL42218 was a reassortant between different serotypes whereas IL41747 was a genetically stable strain. Our data suggest that multiple strains contribute to outbreaks each year. 相似文献