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体外在常规反应条件下,粉防已碱(Tet)对大鼠心肌微粒体Na+,K+-ATPase活性无明显影响,但浓度依赖性抑制Mg2+-ATPase(IC50=179μmol/L).Tet 10和100μmol/L使哇巴因(Oua)抑制Na+,K+-ATPase的量效曲线平行右移.Tet 100μmol/L可显著提高低K+或高Ca2+浓度时的Na+,K+-ATPase活性,但未能明显增加低Na+浓度时该酶的活性.动力学分析提示Tet 100μmol/L增加Na+,K+-ATPase对ATP的亲和力,但不改变其最大反应速度。 相似文献
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E Favre-Dauvergne H Szpirglas L Chikhani P Goudot M Divaris J M Vaillant 《Revue de stomatologie et de chirurgie maxillo-faciale》1992,93(6):366-371
Despite a thorough examination it is not always possible to detect the primary cancer responsible for malignant cervical adenopathy. In the vast majority of cases the metastases arise from an epidermoid carcinoma of the upper respiratory or digestive tract. A possible diagnostic, but also therapeutic procedure is exploratory cervicotomy with extemporaneous examination. The prognosis is poor, both locally (glandular involvement) and generally (metastatic spread). 相似文献
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Abstract: Collagenous spherulosis is a rare, benign breast lesion occuring in less than 1% of benign breast biopsies. All previously reported cases have been discovered as incidental microscopic findings in association with a range of benign to malignant processes. The authors report the first case of collagenous spherulosis presenting as a palpable mass. Immunohistochemistry and electron microscopy performed on this lesion demonstrated the presence of two cell types: epithelial cells and myoepithelial cells with associated basement membranelike material. Collagenous spherulosis may mimic adenoid cystic carcinoma since the epithelial proliferation and spherule formation in collagenous spherulosis closely resembles the changes in adenoid cystic carcinoma. However, adenoid cystic carcinoma is an invasive lesion that is almost always palpable, while collagenous spherulosis is almost always an incidental microscopic finding. Our case illustrates that collagenous spherulosis can also result in a palpable mass, thus palpability of the lesion cannot be used to differentiate these conditions. 相似文献
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喇叭状硅胶管置入治疗食管癌术后吻合口瘘和狭窄 总被引:3,自引:1,他引:2
1 临床资料1.1 患者资料 8例患者中 ,7例为胸中上段食管癌 ,均行食管切除 ,其中 6例行胃代食管 ,1例行结肠代食管 ;6例颈部吻合者术后 6~ 10 d发生吻合口瘘 ,其中 3例经常规治疗即局部换药、抗感染和营养支持治疗 1mo左右愈合 ,但均发生吻合口狭窄而致吞咽困难且经反复扩张治疗效果不佳 ;其余3例中 1例 (为结肠代食管者 )经常规治疗 3mo不愈 ,2例 1wk不愈 ;1例胸内吻合者术后吻合口狭窄 ,经反复扩张治疗效果不佳 ;1例为食管化学烧伤疤痕狭窄钛镍记忆合金支架置入后因肉芽长入管腔再发狭窄 ,不能拔除也不能满意扩张者 .1.2 治疗情况1.2… 相似文献
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The cAMP-mediated protein kinase signal transduction pathway is involved in the pyrogenic effect of CRH in rats 总被引:1,自引:0,他引:1
Objective To determine whether the cyclic adenosine monophosphate (cAMP) mediated protei n kinase signal transduction pathway is involved in the pyrogenic action of cort icotropin releasing hormone (CRH) in rats.Methods Corticotropin releasing hormone, 2’,3’-dideoxy-adenosine (DDA) and adenosi ne-3’,5’-(cyclic) monophosphorothionate, Rp-Isomer (Rp-cAMPS), were administ ered intracerebroventricularly (i.c.v.). The colonic temperature was measure d using a thermistor, and the content of cAMP in the hypothalamus was determined by radioimmunoassay. Hypothalamic incubation was used to assess the effects of CRH on the content of cAMP in the hypothalamus in vitro. Results Microinjection (i.c.v.) of CRH (2.5 μg, 5.0 μg and 10 μg) caused incr eases in colonic temperature and the hypothalamus cAMP level in conscious rats. CRH increased hypothalamus cAMP level in vitro. The pyrogenic effects of CRH w ere abolished or markedly inhibited by prior injection (i.c.v.) of an adenyla te cyclase inhibitor, DDA (30 μg), or an inhibitor of cAMP-dependent protein kinase, Rp-cAMPS (15 μg). Conclusion cAMP mediates the pyrogenic action of centrally administered of CRH in rats, and protein kinase A may play an important role in the central CRH-induced fever. The cAMP-dependent protein kinase signal transduction pathway may be involved in the central mechanisms of the pyrogenic action of CRH in rats. 相似文献