奥氮平与阿立哌唑治疗老年期痴呆患者精神行为症状的对照研究

目的:探讨奥氮平与阿立哌唑对老年期痴呆精神行为症状的疗效及不良反应。方法:将68例老年期痴呆伴BPSD患者随机分为奥氮平组与阿立哌唑组,治疗8周。于治疗前,治疗2、4、8周末以痴呆病理行为评定量表(BEHAVE-AD)评定疗效,以简易智力状态检查表(MMSE)和日常生活能力量表(ADL)评定患者痴呆状况,以治疗中出现的症状量表(TESS)评定不良反应。结果:两组患者治疗后BEHAVE-AD评分显著减少(P<0.01),MMSE评分与治疗前比较无显著性差异(P>0.05),ADL有明显改善(P<0.05),两组间比较差异无显著性(P>0.05);两组患者不良反应均较轻微,不良反应总发生率在两组之间无统计学差异(P>0.05)。结论:奥氮平和阿立哌唑治疗老年期痴呆精神行为症状疗效均确切,起效快,不良反应少。     

Clinicopathological Characteristics and Prognosis of Patients with Adenosquamous Lung Carcinoma

This study was aimed to characterize clinicopathological features and prognosis of patients with adenosquamous lung carcinoma(ASC). Among the 2531 patients with lung cancer who underwent surgery between January 2000 and June 2012 in our hospital, 59 were histologically diagnosed as having ASC. The clinicopathological features and follow-up data of ASC patients were collected and analyzed statistically. Superior lobectomy was accomplished in 40 patients, middle and inferior lobectomy in 3, lobectomy plus partial resection of contralateral lung in 5, partial lung resection in 4, and pneumonectomy in 7. Moreover, 22 cases were found to be adenocarcinoma-predominant, and 18 to be squamous cell carcinoma-predominant. The median survival time was 13.6 months, and the 1-, 3-, and 5-year survival rates were 59.9%, 36.4% and 31.2%, respectively. Of the 52 cases with tissue specimens available, 11 had an EGFR mutation(21.2%) and 2 had a KRAS mutation(3.8%). Multivariate analysis showed that histology subtype, pleural invasion, TNM stage, and postoperative treatment were all independent prognostic factors. The data from the current study demonstrated that SCC-predominant histology represents a better prognosis of ASC. Histology subtype, pleural invasion, TNM stage, and postoperative treatment are independent prognostic factors for ASC and adjuvant therapy may help control the disease.     

Association between body mass index and clinical outcomes of patients after cardiac arrest and resuscitation: A meta-analysis

Background

Obesity as one of the risk factors for cardiovascular diseases increases mortality in general population. Several clinical studies investigated clinical outcomes in patients with different body mass index (BMI) after cardiac arrest (CA). Controversial data regarding BMI on clinical outcomes in those patients exist in those studies. Therefore, we conducted a meta-analysis to evaluate the effect of BMI on survival condition and neurological prognosis in those patients.

On English translation of infant Tuina points in traditional Chinese medicine

1 Introduction In recent years,several international standardized traditional Chinese medicine (TCM) nomenclatures have been published,including the major ones A Proposed Standard International Acupuncture Nomenclature by World Health Organization (WHO) in 1991[1],International Standard Terminologies on Traditional Medicine in the Western Pacific Region[2] by WHO in the Western Pacific Region (WPRO) in 2007 and International Standard Chinese-English Basic Nomenclature of Chinese Medicine[3] by the World Federation of Chinese Medicine Societies (WFCMS) in 2007.However,an English translation of points applied in infant Tuina therapy is neither contained in any of these standardized nomenclatures,nor in major Chinese-English dictionaries of Chinese medicine[4-6].Infant Tuina is an effective and common therapy used in the pediatric department of Chinese medicine.As the points used in infant Tuina therapy are different from the points used in standard acupuncture,and are essential to practice,the authors believe it is important to make an English translation of infant Tuina points and explore the principles and protocol of their translation.     

Microwave absorption properties of lightweight and flexible carbon fiber/magnetic particle composites

Hybridized-carbon-based materials with magnetic metals and oxides have attracted much attention because of their enhanced electromagnetic wave loss. In this study, magnetic particles were coated on the surface of carbon fibers by carbonizing in a nitrogen atmosphere. The morphology, structure, thermolysis, and wave-absorption performance of the carbon fiber/magnetic particle composite were determined. Results show that the in situ-formed magnetic particles (such as Fe₃O₄, NiFe₂O₄, CoFe₂O₄, and Ni₃Fe) are uniformly dispersed along the carbon-based fibers, which exhibit different wave absorption. The absorption of the carbon fiber/magnetic particle composite can be controlled by adjusting the species and concentration of the magnetic particle coating, which provides a new and effective way of endowing the magnetic-particle-coated carbon fibers with good microwave absorption properties.

Hybridized-carbon-based materials with magnetic metals and oxides have attracted much attention because of their enhanced electromagnetic wave loss.     

Anti-inflammatory effects of hinokitiol on human corneal epithelial cells: an in vitro study

Purpose

This study assessed the anti-inflammatory effect and mechanism of action of hinokitiol in human corneal epithelial (HCE) cells.

Methods

HCE cells were incubated with different concentrations of hinokitiol or dimethylsulfoxide (DMSO), which served as a vehicle control. Cell viability was evaluated using Cell Counting Kit-8 (CCK-8) assay. After polyriboinosinic:polyribocytidylic acid (poly(I:C)) stimulus, cells with or without hinokitiol were evaluated for the mRNA and protein levels of interleukin-8 (IL-8), interleukin-6 (IL-6), and interleukin-1β (IL-1β) using real-time PCR analysis and an enzyme-linked immunosorbent assay (ELISA), respectively. Nuclear and cytoplasmic levels of nuclear factor kappa B (NF-κB) p65 protein and an inhibitor of NF-κB α (IκBα) were evaluated using western blotting.

Results

There were no significant differences among the treatment concentrations of hinokitiol compared with cells incubated in medium only. Incubating with 100 μM hinokitiol significantly decreased the mRNA levels of IL-8 to 58.77±10.41% (P<0.01), IL-6 to 64.64±12.71% (P<0.01), and IL-1β to 54.19±8.10% (P<0.01) compared with cells stimulated with poly(I:C) alone. The protein levels of IL-8, IL-6, and IL-1β had similar trend. Further analysis revealed that hinokitiol maintained the levels of IκBα and significantly reduced NF-κB p65 subunit translocation to the nucleus which significantly inhibiting the activation of the NF-κB signal pathway.

Conclusion

Hinokitiol showed a significant protective effect against ocular surface inflammation through inhibiting the NF-κB pathway, which may indicate the possibility to relieve the ocular surface inflammation of dry eye syndrome (DES).     

新型泪道探通针泪道探通后逆行置管的效果分析

目的探讨新型泪道探通针泪道探通后逆行置管的临床效果。方法收集我院2012年6月至2013年10月在我院确诊为泪道疾病需行逆行置管治疗的门诊患者106例（133只眼）,doll’s随机数字法分为观察组53例（68只眼）和对照组53例（65只眼）。对照组采用传统钢针进行泪道探通,观察组采用新型泪道探通针探通,而后进行逆行置管。观察两组治疗有效率,置管成功率,自行脱管率,并发症发生情况。结果两组置管成功率及并发症（鼻腔出血、下睑肿胀）比较, P ＜0．05,差异具有统计学意义;术后6个月内两组置管自行脱落人数经统计学分析,P ＜0．05,差异具有统计学意义;术中观察组因痛疼需追加麻醉者2例,对照组9例,经比较,P ＜0．05,差异具有统计学意义。两组治疗有效率情况经Ridit 分析发现,观察组稍优于对照组（观察组＜对照组）,两组R 的95％置信区间均不包含0．5,差异具有统计学意义。结论新型泪道探通针泪道探通及鼻泪管义管置管术,价廉,操作简单,术中损伤小,患者更易接受,值得推广。     

伴有下斜肌功能亢进外斜V征眼外肌myogenin的研究

目的：：观察伴有下斜肌功能亢进的外斜V征患者下斜肌和内直肌中myogenin活性卫星细胞数量的变化,探讨伴有下斜肌功能亢进的外斜V征的可能发病原因。方法：将伴有下斜肌功能亢进外斜V征患者6例中切除的下斜肌及内直肌作为斜视组,行myogenin免疫组织化学染色,统计myogenin阳性染色的卫星细胞核数;角膜移植供体的下斜肌及内直肌(6例)作为对照组。结果：斜视组和对照组下斜肌中myogenin免疫染色阳性肌卫星细胞数占总细胞数比例分别为(22.7±7.03)%和(4.2±0.75)%,具有统计学差异(P<0.05)。斜视组和对照组内直肌中myogenin免疫染色阳性的肌卫星细胞数分别为(2.2±0.75)%和(4.5±1.05)%,具有统计学差异(P<0.05)。结论：首次报道伴有下斜肌功能亢进外斜V征患者眼外肌中表达 myogenin 免疫染色阳性肌卫星细胞的变化。myogenin可能是伴有下斜肌功能亢进外斜 V 征的致病因素。     

三种不同方法测量年龄相关性白内障患者前房深度的比较

目的：：比较光学生物学测量仪( IOL Master )、接触式和浸润式A超对前房深度( anterior chamber depth,ACD)的测量结果,分析三种测量方法是否存在差异及其一致性。方法：选取2013-07/10于我院诊断为年龄相关性白内障患者58例98眼术前分别进行IOL Master、接触式A超和浸润式A超的ACD测量,应用方差分析对三种方法的测量结果差异进行比较,应用Blant-Altman分析法比较其一致性。结果：IOL Master 测量 ACD 为2.31~3.90(平均3.03±0.38) mm;接触式 A 超测量 ACD 为1.51~4.06(平均2.88±0.56)mm;浸润式A超测量ACD为1.99~4.17(平均3.17±0.38)mm。 IOL Master和接触式A超的ACD测量值差异有统计学意义( P=0.022<0.05)。 IOL Master和浸润式A超ACD测量值差异有统计学意义( P=0.031<0.05)。接触式A超与浸润式A超ACD测量值差异有统计学意义(P=0.000<0.05)。三种方法相互间一致性均较差。结论：三种方法测量白内障患者ACD时,浸润式A超测得结果最大,IOL Master次之,接触式A超测得结果最小,三者相互间一致性均较差,临床不建议相互替代。     

脉络膜厚度与CSCR的病例对照研究与Meta分析

目的：定量分析中心性浆液性脉络膜视网膜病变( central serous chorioretinopathy,CSCR)患者黄斑中心凹下脉络膜厚度( subfoveal choroidal thickness,SFCT)改变。
　　方法：采用病例对照研究及Meta分析。连续的CSCR患者46例纳入研究,CSCR患者散瞳后前置镜眼底检查,荧光素眼底血管造影和吲哚菁绿血管造影检查确诊。选择同期年龄、性别、屈光度及眼轴匹配的正常人62例62眼作为正常对照组。用加强成像深度扫描OCT检测并比较CSCR组及对照组SFCT。单因素和多因素分析 SFCT 与各临床资料之间的关系。 Meta分析用Stata软件计算两组之间的加权均数差。
　　结果：CSCR患者的平均SFCT为397.34±83.91μm,正常对照组为274.48±62.57μm。 CSCR组SFCT较对照组明显增厚,差异有统计学意义(P<0.01)。单因素与多因素线性回归分析, SFCT与CSCR诊断显著相关。 Meta分析结果：CSCR组的黄斑中央凹下脉络膜较正常组厚,加权平均差异为156.13μm(95% CI：137.43,174.83)。
　　结论：CSCR患者黄斑中央凹下脉络膜较正常眼厚,增厚的SFCT与CSCR诊断存在相关性。