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991.
992.
Lujing Li Xinchuan Zhou Xinbao Zhao Shaoyun Hao Jiyi Yao Wenjing Zhong Hui Zhi 《Ultrasound in medicine & biology》2017,43(11):2582-2590
Non-mass breast lesions on ultrasound (US) are areas without an associated mass. The purpose of this study was to evaluate whether combining B-mode US with color Doppler US and strain elastography (SE) improves US differentiation between benign and malignant non-mass breast lesions and the decision for biopsy. In this prospective study, three different radiologists analyzed the US images of 77 non-mass lesions independently and recorded Breast Imaging Reporting and Data System (BI-RADS) categories for four data sets. The image characteristics and BI-RADS categories of the four data sets were analyzed by another radiologist. The final diagnosis was made on the basis of pathologic findings. Values for area under the receiver operating curve (AUC), sensitivity, specificity and accuracy were compared among the data sets. The AUC of B-mode US combined with both color Doppler US and SE was greater than that of B-mode US alone (0.666 vs. 0.828) (p = 0.011). The specificity of making the decision for biopsy increased from 6.5% to 38.7% when B-mode US was combined with color Doppler and SE, without a statistically significant change in sensitivity (p < 0.001). Combined use of color Doppler and SE could improve the diagnostic value of B-mode US in distinguishing benign from malignant non-mass breast lesions and the specificity of making the decision for biopsy of non-mass breast lesions. 相似文献
993.
994.
目的:评价消痔膏敷贴疗法治疗嵌顿痔的临床疗效。方法:将70例嵌顿痔患者随机分为治疗组(n=35)和对照组(n=35),治疗组应用消痔膏贴敷治疗,对照组应用龙珠软膏贴敷治疗,疗程为10 d。评价两组的临床疗效,比较两组患者主要临床症状、体征的改善情况。结果:治疗后,治疗组和对照组的临床总有效率分别为88.57%和54.28%,治疗组疗效优于对照组(P0.05);两组患者的肛周水肿、疼痛、渗出、便血情况较治疗前均显著改善(P0.05),且治疗组患者的肛周水肿、疼痛、渗出情况明显优于对照组(P0.05)。结论:消痔膏贴敷疗法治疗嵌顿痔能有效缓解患者的疼痛、渗出、水肿等主要临床症状与体征,值得在嵌顿痔保守治疗中推广应用。 相似文献
995.
Meng Zhang Zhong-Tang Zhao Xian-Jun Wang Zhong Li Lei Ding Shu-Jun Ding 《The American journal of tropical medicine and hygiene》2012,87(6):1099-1104
To elucidate the epidemic status, clinical profile, and current diagnostic issues of scrub typhus in Shandong Province, we analyzed the surveillance data of scrub typhus from 2006 to 2011 and conducted a hospital-based disease survey in 2010. Scrub typhus was clustered in mountainous and coastal areas in Shandong Province, with an epidemic period from September to November. The most common manifestations were fever (100%), eschar or skin ulcer (86.3%), fatigue (71.6%), anorexia (71.6%), and rash (68.6%). Predominant complications included bronchopneumonia, toxic hepatitis, and acute cholecystitis in 21.6%, 3.9%, and 2.9% of the cases, respectively. Severe complications including toxic myocarditis, heart failure, pneumonedema, pleural effusion, and emphysema were first reported in Shandong. Missed and delayed diagnosis of scrub typhus was common in local medical institutions. Alarm should be raised for changes of clinical features and current diagnostic issues of scrub typhus in newly developed endemic areas. 相似文献
996.
Arsenic trioxide intravenous infusion combined with transcatheter arterial chemoembolization for the treatment of hepatocellular carcinoma with pulmonary metastasis: Long‐term outcome analysis 下载免费PDF全文
997.
Assessment of the involvement of the macrophage migration inhibitory factor–glucocorticoid regulatory dyad in the expression of matrix metalloproteinase‐2 during periodontitis 下载免费PDF全文
Josefine Hirschfeld Mohammed Howait Alexandru Movila Marijo Parčina Isabelle Bekeredjian‐Ding James Deschner Søren Jepsen Toshihisa Kawai 《European journal of oral sciences》2017,125(5):345-354
Macrophage migration inhibitory factor (MIF) is a proinflammatory cytokine and counter‐regulator of endogenous glucocorticoids (GCs). It is implicated in acute and chronic inflammatory diseases. This study investigated the role of the MIF–GC regulatory dyad in the expression and release of matrix metalloproteinase‐2 (MMP‐2) during periodontitis, in vivo and in vitro. In a Mif‐knockout (KO) mouse model of ligature‐induced periodontitis, gingival tissues and blood were collected and analysed for levels of interleukin‐6 (IL‐6), MIF, MMP‐2, and corticosterone. In addition, human gingival fibroblasts (HGFs) were tested for production of IL‐6 and MMP‐2 after stimulation with hydrocortisone (HC), MIF, tumour necrosis factor‐alpha (TNF‐α), or Fusobacterium nucleatum, a pathogen known to elicit immune responses during periodontitis. Wild‐type (WT) mice showed a local and systemic increase of MIF levels during inflammation, which was confirmed by increased local IL‐6 concentrations. Systemic GC levels were reduced in WT and Mif‐KO mice during inflammation, with overall lower concentrations in Mif‐KO mice. In vivo and in vitro, MMP‐2 production was not dependent on MIF or inflammatory stimuli, but was inhibited by HC. Therefore, MIF does not appear to stimulate expression of MMP‐2 in the gingival tissues, whereas GC upregulates MIF and downregulates MMP‐2. Our findings further suggest that MIF may regulate systemic GC levels. 相似文献
998.
In vivo confocal microscopic investigation of the cornea after autologous implantation of lenticules obtained through small incision lenticule extraction for treatment of hyperopia 下载免费PDF全文
999.
Peiying Liu Hao Huang Nancy Rollins Lina F. Chalak Tina Jeon Cathy Halovanic Hanzhang Lu 《NMR in biomedicine》2014,27(3):332-340
The cerebral metabolic rate of oxygen (CMRO2) is the rate of oxygen consumption by the brain, and is thought to be a direct index of energy homeostasis and brain health. However, in vivo measurement of CMRO2 is challenging, in particular for the neonatal population, in whom conventional radiotracer methods are not applicable because of safety concerns. In this study, we propose a method to quantify global CMRO2 in neonates based on arteriovenous differences in oxygen content, and employ separate measurements of oxygenation and cerebral blood flow (CBF) parameters. Specifically, arterial and venous oxygenation levels were determined with pulse oximetry and the novel T2 relaxation under spin tagging (TRUST) MRI, respectively. Global CBF was measured with phase contrast (PC) flow velocity MRI. The proposed method was implemented on a standard 3‐T MRI scanner without the need for any exogenous tracers, and the total scan duration was less than 5 min. We demonstrated the feasibility of this method in 12 healthy neonates within an age range of 35–42 gestational weeks. CMRO2 values were successfully obtained from 10 neonates. It was found that the average CMRO2 in this age range was 38.3 ± 17.7 µmol/100 g/min and was positively correlated with age (p = 0.007; slope, 5.2 µmol/100 g/min per week), although the highest CMRO2 value in this age range was still less than half of the adult level. Test–retest studies showed a coefficient of variation of 5.8 ± 2.2% between repeated CMRO2 measurements. In addition, given the highly variable blood flow velocity within this age range, it is recommended that the TRUST labeling thickness and position should be determined on a subject‐by‐subject basis, and an automatic algorithm was developed for this purpose. Although this method provides a global CMRO2 measure only, the clinical significance of an energy consumption marker and the convenience of this technique may make it a useful tool in the functional assessment of the neonatal population. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献
1000.
随着经济的发展及汽车的普及,由车祸及工伤事故导致的胸部创伤日趋增多,胸部创伤中61%~90%为肋骨骨折,肋骨骨折中又绝大多数为单纯性多发肋骨骨折。早期固定是多发肋骨骨折缓解疼痛、预防骨折错位及控制反常呼吸的关键措施,然而目前临床常用的胸带固定法却存在种种弊端。为此,笔者将纳米高分子材料胸部护板应用于单纯性多发肋骨骨折病人,并与传统的胸带固定法进行比较。现报道如下。 相似文献