Effects of acetylsalicylic acid on serum paraoxonase activity,Ox-LDL,coenzyme Q10 and other oxidative stress markers in healthy volunteers

Objectives:The aim of the study was to examine the effects of acetylsalicylic acid (ASA) on oxidative stress in healthy volunteers.Design and Methods:30 volunteers of which 17 received ASA as 100 mg/day (Group I) and 13 received ASA as 150 mg/day (Group II) for 2 months. Serum paraoxonase 1 (PON1), arylesterase, total antioxidant status (TAS), total oxidant status (TOS), oxidized LDL (Ox-LDL) and coenzyme Q₁₀ (CoQ₁₀) levels were measured before and 1 and 2 months after treatment.Results:There was no significant differences between the measured parameters of the groups. However, TOS and Ox-LDL levels of group II were significantly reduced after 2 months of treatment (p < 0.05).Conclusions:Significantly inhibition of LDL oxidation and significantly reduction in TOS levels of group II after 2 months of ASA treatment shows that ASA treatment may contribute to the prevention of atherosclerosis, a beneficial effect which is dose and time dependent.     

Collagen matrix assembly is driven by the interaction of von Hippel-Lindau tumor suppressor protein with hydroxylated collagen IV alpha 2

Inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene predisposes to vascular tumor formation in several organs. VHL regulates two evolutionary conserved pathways: the targeting of hydroxylated hypoxia-inducible factor-alpha (HIF-alpha) for proteasomal degradation and the remodeling of extracellular matrix (ECM). The biochemical mechanisms of the ECM assembly pathway remain poorly defined. Here, we provide evidence supporting a biochemical role for VHL in ECM assembly. We show that VHL directly binds to the collagen IV alpha 2 (COL4A2) chain and that this interaction is necessary for its assembly into the ECM. The VHL-COL4A2 interaction is dependent on endoplasmic reticulum (ER)-mediated COL4A2 hydroxylation and independent of cytosolic, hypoxia regulated HIF-alpha-modifying enzymes. We find that the N-terminal tail of COL4A2 protrudes from the ER lumen into the cytosol where it is bound by VHL. Failure of VHL to interact with COL4A2 correlates with loss of collagen IV network formation in vitro and collagen IV remodeling in vivo. Our data suggest a HIF-alpha-independent role for the VHL-COL4A2 interaction in suppression of angiogenic tumor formation through collagen IV network assembly.     

Metabolic diseases and pregnancy

The skin mirrors the hormonal metabolic and physiologic changes that occur during pregnancy. The metabolic effects are manifested primarily in accentuation of two disorders, porphyria cutanea tarda and acrodermatitis enteropathica. The former may be exacerbated, not only during pregnancy, but also during the post-partum period and with the intake of estrogen-containing birth control pills. Exacerbations of acrodermatitis enteropathica characteristically appear during pregnancy.     

Expanding the histologic spectrum of angina bullosa hemorrhagica: report of one case

Angina bullosa hemorrhagica (ABH) is a rarely described phenomenon in the dermatology/dermatopathology literature. It is a self-limited condition occurring exclusively in the oral mucosa characterized clinically by tense hemorrhagic blisters that heal without any sequelae and histologically by a pauci-inflammatory subepithelial hemorrhagic bulla with occasional lymphocytic infiltrate.A 24-year-old healthy woman presented with a 4-month history of recurrent tense blisters over the buccal mucosa which lasted for a few days and resolved without scarring. Histopathology revealed a hemorrhagic subepithelial bulla containing numerous neutrophils with a moderately dense superficial perivascular and interstitial neutrophilic infiltrate. Direct immunofluorescence studies were negative. Based on these findings, the diagnosis of ABH was made. To the best of our knowledge, this is the first report of ABH mimicking histologically neutrophil-rich subepithelial blistering disorders.     

某油田公司职业卫生现状调查

目的了解某油田公司职业卫生现状。方法现场调查该公司各分厂生产工艺流程、有害作业岗位、职业病危害因素分布、接触人数、职业病危害防护设施、个人使用的职业病防护用品、建设项目职业病危害预评价与控制效果评价的情况。对有害作业岗位作业环境进行职业病危害因素监测,对全公司从事有毒有害职工进行职业性健康检查。结果该公司存在有毒有害因素分厂的8家企业,检测噪声强度315个点,合格率95.2％;化学毒物524个点,合格率96.7％;粉尘浓度26个点,合格率100％;职业病检出率为0,但1426人接触噪声人员中,检出听力损失医学观察对象85人,异常检出率5.96％。体检项目：电测听异常率最高为21.3％,其次B超异常检出率为18.3％。结论该油田公司职业病危害因素主要为噪声、苯系物、粉尘及职业危害因素的联合作用,噪声危害应成为职业卫生工作的防治重点。虽然该公司各有害因素检测合格率较高,但应加强超标点个人防护用品有效使用和监督管理。     

维医沙疗与其他区域沙疗的沙子特性对比研究

维医沙疗的机理与沙子特性存在必然联系,本文对比研究了维医沙疗与其他区域沙疗的沙子特性。研究结果表明吐鲁番沙疗中心沙子中磁矿含量较多,比重较大,沙子的颗粒较为均匀,磁矿石微粒较大,并具有较强磁性,呈现出灰黑色。本研究结果对进一步探讨维医沙疗机理提供了科学依据。     

重度溃疡性结肠炎1例内科优化治疗

重度溃疡性结肠炎通常病情重、发展快,出现危及生命的并发症和结肠切除的风险特别高.对于溃疡性结肠炎,当内科治疗无效时可考虑手术治疗.1例重度溃疡性结肠炎经采用常规药物治疗无效,出现低血压性休克等并发症,达到行外科手术的指征,因患者为年轻未婚、未恋女性,术后存在影响生活质量、性功能障碍、不孕等风险,故经分析内科疗效不佳的原...