全文获取类型
收费全文 | 932733篇 |
免费 | 66403篇 |
国内免费 | 1343篇 |
专业分类
耳鼻咽喉 | 12966篇 |
儿科学 | 24376篇 |
妇产科学 | 23242篇 |
基础医学 | 133074篇 |
口腔科学 | 28293篇 |
临床医学 | 80704篇 |
内科学 | 183348篇 |
皮肤病学 | 19250篇 |
神经病学 | 72273篇 |
特种医学 | 36829篇 |
外国民族医学 | 79篇 |
外科学 | 152180篇 |
综合类 | 18046篇 |
现状与发展 | 1篇 |
一般理论 | 235篇 |
预防医学 | 61834篇 |
眼科学 | 21312篇 |
药学 | 72592篇 |
3篇 | |
中国医学 | 2162篇 |
肿瘤学 | 57680篇 |
出版年
2018年 | 8986篇 |
2017年 | 7049篇 |
2016年 | 7780篇 |
2015年 | 8885篇 |
2014年 | 12017篇 |
2013年 | 17541篇 |
2012年 | 24138篇 |
2011年 | 25077篇 |
2010年 | 14843篇 |
2009年 | 14300篇 |
2008年 | 24636篇 |
2007年 | 25731篇 |
2006年 | 26528篇 |
2005年 | 25462篇 |
2004年 | 24590篇 |
2003年 | 23649篇 |
2002年 | 23177篇 |
2001年 | 54744篇 |
2000年 | 56571篇 |
1999年 | 46972篇 |
1998年 | 10740篇 |
1997年 | 9472篇 |
1996年 | 9604篇 |
1995年 | 8936篇 |
1994年 | 8289篇 |
1993年 | 7601篇 |
1992年 | 35515篇 |
1991年 | 33926篇 |
1990年 | 32751篇 |
1989年 | 31883篇 |
1988年 | 29010篇 |
1987年 | 28262篇 |
1986年 | 26297篇 |
1985年 | 25153篇 |
1984年 | 17839篇 |
1983年 | 15151篇 |
1982年 | 7799篇 |
1981年 | 6774篇 |
1979年 | 15784篇 |
1978年 | 10601篇 |
1977年 | 9054篇 |
1976年 | 7872篇 |
1975年 | 8629篇 |
1974年 | 10466篇 |
1973年 | 9858篇 |
1972年 | 9357篇 |
1971年 | 8852篇 |
1970年 | 8426篇 |
1969年 | 7924篇 |
1968年 | 7200篇 |
排序方式: 共有10000条查询结果,搜索用时 17 毫秒
991.
B E Buck L Resnick S M Shah T I Malinin 《Clinical orthopaedics and related research》1990,(251):249-253
This study demonstrates by a virologic culture method that human immunodeficiency virus (HIV) resides in bone. After freezing, some initially positive specimens no longer yielded virus, but those that continued to yield virus were not further altered by subsequent washing, which removed essentially all marrow, or by freeze-drying. The safeguards against potential transmission of HIV by a bone allograft are principally the screening and testing methods previously described, although there may be a further reduction of the remote residual risk by the freezing step in the usual technical sequence for tissue banking by sterile techniques. 相似文献
992.
T. Nishikawa H. Kuwahara A. Tsuda M. Tanaka I. Koga Y. Uchida 《Human psychopharmacology》1990,5(4):363-368
Ceruletide, a potent analogue of cholecystokinin, was administered by injection to eight schizophrenics treated with neuroleptics. We examined the dose–response effect on microvibration (MV) recorded from the chin of these patients. After 15 min of bed rest, MV was recorded for 5 min as a control recording. Subsequently, saline or ceruletide, at a dose of either 0.4 m?g/kg or at 0.8 m?g/kg, was injected according to a Latin square design with an interval of 4 weeks for washing out the drug effect and MV was recorded for 30 min. MV data obtained were subjected to the fast Fourier transform and an average power spectrum was computed. A three-way analysis of variance for these data was performed upon dose-effect, time-effect after treatment, and band-effect of the average power spectrum. The present results were similar to previous findings which had revealed effects of ceruletide on tardive dyskinesia symptoms, namely, the effects of ceruletide on MV were different according to the subjects (three cases: facilitation followed by inhibition, three cases: inhibition, two cases: no effects). The dose-response curve of ceruletide appears to be linear in some cases and an inverted U-shape in other cases. Present findings showed small doses of systemically administered ceruletide would modify muscle tonus of schizophrenics under chronic treatment of neuroleptics, and provided further reason for the therapeutic drug of tardive dyskinesia. 相似文献
993.
Mycosis fungoides (MF) is the most common cutaneous T-cell lymphoma. We report a case in which identical T-cell clones were identified in both patch and tumour stage lesions and in which the tumorous deposits, containing CD30-positive cells, repressed spontaneously. We discuss the differential diagnosis of the tumorous lesions and the spectrum of GD30-positive proliferative T-cell disorders. 相似文献
994.
Anu Kilpi Alison M. Rich Yrjö T. Konttinen Peter C. Reade 《European journal of oral sciences》1996,104(3):278-284
Oral mucosal lichen planus (OMLP) is a well recognized mucosal disease with unknown etiology. Considerable controversy exists as to whether OMLP is intrinsically premalignant, or if the disorder facilitates the development of oral mucosal squamous cell carcinoma (OMSCC) by external factors. The aim of the present study was to investigate the expression of c-erbB-2 protein in the keratinocytes of initial biopsies of oral mucosal disorders diagnosed as OMLP with no evidence of epithelial dysplasia. and to compare the results with the expression of c-erbB-2 protein in subsequent biopsies obtained from the same patients. These results were compared with the findings from control groups (patients with dysplasia with no evidence of OMLP, patients with OMSCC with no evidence of OMLP and normal oral mucosa). The expression of the c-erbB-2 protein was evaluated by immunohistochemical staining of the gene product with the avidin-biotin-complex method using paraffin-embedded tissue sections. Five of the initial biopsies from patients with OMLP expressed the c-erhB-2 protein and one did not. None of the OMLP cases that subsequently showed evidence of dysplasia expressed the c-erhB-2 protein, and of the three OMSCC specimens from the patients with OMLP. two were negative and one expressed c-erbB-2 protein. The specimens from the control groups all expressed the c-erhB-2 protein. The results indicated the probability of the absence of c-erbB-2 staining being an indication of a potential for neoplastic transformation in OMLP with dysplastic changes. 相似文献
995.
Twenty-two infants of isolated ventricular septal defect with congestive heart failure were fed with lower-sodium content formula-Lonalac (Mead-Johnson) to study the clinical response of treatment for congestive heart failure. There were no significant changes of intake, urinary output, serum sodium, potassium and osmolality before, 2 days and 6 days after Lonalac feeding. The low sodium content formula may feed the infants with congestive heart failure in addition to the traditional anticongestive therapy. 相似文献
996.
997.
S Kato T Morie K Hino T Kon S Naruto N Yoshida T Karasawa J Matsumoto 《Journal of medicinal chemistry》1990,33(5):1406-1413
With the purpose of obtaining more potent and selective gastric prokinetic than metoclopramide (1), a new series of N-[(2-morpholinyl)alkyl]benzamides (17-52) were synthesized and their gastric prokinetic activity was evaluated by determining effects on the gastric emptying of phenol red semisolid meal and of resin pellets solid meal in rats and mice. The morpholinyl moiety was newly designed after consideration of the side-chain structure of cisapride (2) and produced the desired activity when coupled with the 4-amino-5-chloro-2-methoxybenzoyl group of both metoclopramide and cisapride. Modification of the substituents of the benzoyl group markedly influenced the activity. In particular, 4-amino-N-[(4-benzyl-2-morpholinyl)methyl]-5-chloro-2-methoxybenzamide (17) and the 4-(dimethylamino) and 2-ethoxy analogues (25 and 29) of 17 showed potent and selective gastric prokinetic activity along with a weak dopamine D2 receptor antagonistic activity. 相似文献
998.
FR900403, a new antifungal antibiotic produced by a Kernia sp 总被引:3,自引:0,他引:3
T Iwamoto A Fujie Y Tsurumi K Nitta S Hashimoto M Okuhara 《The Journal of antibiotics》1990,43(9):1183-1185
999.
A Fujie T Iwamoto N Shigematsu M Ezaki M Hino S Hashimoto M Okuhara M Kohsaka H Imanaka 《The Journal of antibiotics》1990,43(5):449-455
FR112123 is a new oligopeptide antibiotic produced by Streptomyces viridochromogenes No. 7587. The structure of FR112123 is elucidated as N-(N6-(N2-glycyl-L-glutaminyl)-D-lysyl)-D-alanine (1) by spectroscopic and chemical evidence. It resembles a partial structure of peptidoglycan in bacteria. The compound has a superior activity against an Escherichia coli mutant sensitive to inhibitors of cell wall synthesis, although it has a weak activity against the parent strain. These suggest that FR112123 might act on the biosynthesis of bacterial cell wall. 相似文献
1000.